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Yang C.,Liaoyang Central Hospital | Ding Y.,Liaoyang Central Hospital | Kong C.,The First Affiliated Hospital of China Medical University
Chinese Journal of Andrology | Year: 2015

Objective To evaluate the erectile function of penile cancer patients after Glans-preserving surgery,and explore the relationship between erectile function and anxiety or depression. Methods Clinical data of 42 cases with superficial penile cancer who underwent glans-preserving surgery in our hospital were retrospectively analyzed. International Index of Erectile Function (IIEF-15),self-rating anxiety/depressions cales(SAS/SDS) were used to assess the erectile function,anxiety and depression of patients before and afteroperation, and the relationships were analyzed. Results Two cases of recurrence in situ found at 9 and 12 months,which were successfully managed by a second glans-preserving surgery. Compared with that of preoperation,the degree of erectile function were increased after operation (P<0.05), However, the anxiety and depression degree were decreased (P<0.05). In addition, the erectile function was negatively correlated with anxiety or depression. Conclusion The score of erectile function of penile cancer patients were higher after glans-preserving surgery,and the erectile function were significantly correlated with anxiety and depression. © 2015, Shanghai Jiaotong University School of Medicine. All rights reserved.

Wang B.,The First Affiliated Hospital of China Medical University | Liu L.,The First Affiliated Hospital of China Medical University
Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology | Year: 2016

Along with the aging process, the spectrum of liver disease changes greatly. Nonalcoholic fatty liver disease (NAFLD) in elderly people lead to low liver function and is also the major cause of extrahepatic diseases, such as cardiovascular disease and malignant tumor. This review provides an overview of the morphological structure and function of the liver in aged people, and discusses the characteristics of weakness, malnutrition and limited movement in the elderly, as well as the current status of multiple diseases and multiple drug use. Finally, this article puts forward some appropriate regimens for the diagnosis and treatment of NAFLD in elderly people to provide a reference for clinical practice.

Tian A.,Northeastern University China | Qin X.F.,The First Affiliated Hospital of China Medical University | Wu A.,The First Affiliated Hospital of China Medical University | Wu A.,China Medical University at Heping | And 8 more authors.
International Journal of Nanomedicine | Year: 2015

Cells respond to their surroundings through an interactive adhesion process that has direct effects on cell proliferation and migration. This research was designed to investigate the effects of TiO2 nanotubes with different topographies and structures on the biological behavior of cultured cells. The results demonstrated that the nanotube diameter, rather than the crystalline structure of the coatings, was a major factor for the biological behavior of the cultured cells. The optimal diameter of the nanotubes was 20 nm for cell adhesion, migration, and proliferation in both glioma and osteosarcoma cells. The expression levels of vitronectin and phosphor-focal adhesion kinase were affected by the nanotube diameter; therefore, it is proposed that the responses of vitronectin and phosphor-focal adhesion kinase to the nanotube could modulate cell fate. In addition, the geometry and size of the nanotube coating could regulate the degree of expression of acetylated α-tubulin, thus indirectly modulating cell migration behavior. Moreover, the expression levels of apoptosis-associated proteins were influenced by the topography. In conclusion, a nanotube diameter of 20 nm was the critical threshold that upregulated the expression level of Bcl-2 and obviously decreased the expression levels of Bax and caspase-3. This information will be useful for future biomedical and clinical applications. © 2015 Tian et al.

Lv M.,The First Affiliated Hospital of China Medical University | Li B.,Liaoning Medical University | Li Y.,The First Affiliated Hospital of China Medical University | Mao X.,The First Affiliated Hospital of China Medical University | And 2 more authors.
Asian Pacific Journal of Cancer Prevention | Year: 2011

Introduction: Breast cancer is increasingly regarded as a heterogeneous disease which can be classified into distinct molecular subtypes with prognostic significance. Materials and methods: ER, PR, HER2 and ki-67 were used to divided 102 breast cancers treated with neoadjuvant chemotherapy (NCT) into 4 subtypes: luminal A (ER+, PR+, HER2-, and ki-67 ≤14%), luminal B (ER+, PR+, HER2- and ki-67>14%; ER+ and/or PR+, HER2+), HER2-overexpression (ER-, PR- and HER2+) and triple-negative (ER-, PR-,and HER2 Results: Among 102 patients, a pCR was seen in 16 (15.7%) patients. The pathologic complete remission (pC) rates according to different subtypes are as follows: luminal A, 0 of 20 (0.0%), luminal B, 2 of 23 (8.7%), HER2-overexpression 4 of 18 (22.2%), and triple-negative, 10 of 41 (24.4%) (p=0.041). In triple-negative subtype patients, the rates of pCR differed significantly among the 3 chemotherapy regimens with 5.6% (1/18) for CEF (cyclophosphamide, epirubicin and flurouracil), 20.0% (1/5) for TE (docetaxel and epirubicin) and 44.4% (8/18) for TCb (docetaxel and carboplatin) (p=0.024). In locally advanced breast cancer patients, the rates of pCR seem to differ among the 3 chemotherapy regimens with 6.7% (2/30) for CEF, 0.0% (0/8) for TE and 23.1% (6/26) for TCb, but this did not attain statistical significance (p>0.05). Conclusions: Molecular subtypes are good predictors for response to NCT in breast cancer patients in Northeast China. Compared with luminal A tumors, HER2-overexpression and triple-negative subtypes are more sensitive to NCT. For triple-negative breast cancer, we concluded that the TCb combination is a promising NCT regimen. Our results also indicated that the TCb combination is promising for the treatment of locally advanced breast cancer.

Shao C.,The First Affiliated Hospital of China Medical University | Gu J.,The First Affiliated Hospital of China Medical University | Meng X.,The First Affiliated Hospital of China Medical University | Zheng H.,The First Affiliated Hospital of China Medical University | Wang D.,The First Affiliated Hospital of China Medical University
International Journal of Clinical and Experimental Medicine | Year: 2015

Objectives: Glucose fluctuation is suggested to be the leading cause of beta-cell damages. To determine how it induces beta-cell dysfunction, we systematically evaluated the effects of intermittent high glucose (IHG) in INS-1 rat pancreatic beta-cells on their proliferation activity, apoptosis, insulin secretion, reactive oxygen species (ROS), intracellular concentration of Ca2+ ([Ca2+]i), and the PTEN expression as well as AKT phosphorylation. Methods: Prior to the examinations, INS-1 cells were treated with normal glucose (NG, 11.1 mmol/L), sustained high glucose (SHG, 33 mmol/L), IHG (switching per 12 h in 11.1 mmol/l or 33 mmol/L), NG+α-lipoic acid (LA, pretreated with LA 12 h before exposure to NG), SHG+LA (pretreated with LA 12 h before being exposed to 33.3 mmol/L glucose) and IHG+LA (pretreated with LA 12 h before being cultured with IHG). The cells in each group were cultured with indicated concentrations of glucose for 3 days. The evaluations were carried out on the cell viability, apoptosis rate, insulin secretion, [Ca2+]i, ROS and the expressions of PTEN and p-AKT. Results: The current study determined that IHG induces more apoptosis and significant increases of [Ca2+]i and intracellular ROS levels, compared to SHG and NG treatments to INS-1 cells. Moreover, IHG leads to more than 20% decrease on cell viability and over 50% reduction on insulin secretion (from 5.48±0.79 mIU/L to 2.51±0.58 mIU/L). The negative regulation of IHG on insulin signaling in beta-cells is identified via western blot analysis with results of the elevated expression of PTEN and lowered phosphorylation levels of AKT post IHG treatment. While the pretreatment of the antioxidant LA can significantly suppress the above responses induced by high glucose treatment. Conclusions: This study demonstrated that IHG plays a detrimental role in the viability, expansion, and function of beta-cells. IHG could be more harmful to the INS-1 cells than the SHG treatment. The rate increase of apoptosis in beta-cells could be caused by the suppressed insulin signaling, which is resulted from the raised ROS level by abnormal glucose treatments. Undergoing oxidative stress induced by high glucose treatments, including SHG and IHG, might be an important player in mediating the injury process to beta-cells, concluded from the beneficial rescue by the antioxidant LA treatment. © 2015, E-Century Publishing Corporation. All rights reserved.

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