Li Q.,The Fifth Hospital of Wuhan City |
Ling F.,The Fifth Hospital of Wuhan City |
Nie D.,The Fifth Hospital of Wuhan City |
Zeng W.,The Fifth Hospital of Wuhan City |
Qi A.,The Fifth Hospital of Wuhan City
Medical Journal of Wuhan University | Year: 2012
Objective: To observe the influence of combination therapy of probucol, aspirin and statins drugs (PAS) on inflammatory factors such as high sensitivity C-reactive protein (hs-CRP), marix metalloproteinase-7 (MMP-7) and marix metalloproteinase-8 (MMP-8) in patients with acute cerebral infarction (ACI) and its effect on the role of carotid artery plaque. Methods: According to the results of carotid artery ultrasound, 135 cases of patients with ACI were divided into carotid stable plaque group (n=45) and carotid vulnerable plaque group (n=90). Stable plaque group was considered as control group. Ninety cases with carotid vulnerable plaque were randomly divided into aspirin and statins drugs (AS) group (n=45, aspirin 100 mg/d and atorvastatin 20 mg/d, orally) and PAS group (n=45, aspirin 100 mg/d, atorvastatin 20 mg/d, and probucol 0.25 g, b i.d., orally). Serum hs-CRP, MMP-7, and MMP-8 levels were detected in all patients before treatment and four weeks after treatment. The intima-media thickness (IMT), plaque area and echogenicity of carotid plaques in all cases were evaluated by Doppler ultrasonography during a 12-month follow-up period. Results: Before treatment, serum hs-CRP, MMP-7, and MMP-8 levels in two subgroups of vulnerable plaque group (AS group and PAS group) were higher than that in stable plaque group (control group) (all P<0.01), while no significant differences were observed between AS group and PAS group (all P>0.05). Levels of hs-CRP, MMP-7 and MMP-8 decreased significantly in AS group after 4 weeks, as well as in PAS group(all P<0.01). Four weeks later, the hs-CRP, MMP-7 and MMP-8 levels were obviously higher in PAS group than in AS group (all P<0.01). Whether in AS or PAS group, significant increase in echogenicity of carotid plaques and decrease in plaque area and IMT were noted after therapy. However, the value of IMT and plaque area were significantly less in PAS group as compared to AS group (both P<0.01). The cases with increasing hypoechoic plaques were significantly more in PAS group after treatment than in AS group (P<0.01). Conclusion: Combination therapy of probucol, aspirin and statins drugs could rapidly reduce serum inflammatory factors in patients with ACI, and might have stronger anti-inflammation function, so as to reverse or stabilize the atherosclerosis plaque.
Fu L.,The Fifth Hospital of Wuhan City |
Liu X.,Hubei Cancer Hospital
World Chinese Journal of Digestology | Year: 2016
AIM: To evaluate the clinical effects of Jiawei Shengyang Yiwei soup combined with postoperative chemotherapy for colorectal cancer. METHODS: Ninety-eight colorectal cancer patients surgically treated from October 2013 to October 2014 at the Fifth Hospital of Wuhan were chosen and randomly divided into either a control group or an observation group, with 49 patients in each group. The control group received postoperative chemotherapy alone, and the observation group received Jiawei Shengyang Yiwei soup combined with postoperative chemotherapy. Clinical effects were compared between the two groups. RESULTS: After treatment, carcinoembryonic antigen, white blood cell count, neutrophil count, and C reactive protein significantly decreased (P < 0.05), while quality of life (physiological status, social and family status, emotional status, functional status, public sector, additional attention, and total score) scores significantly increased in the two groups (P < 0.05). Carcinoembryonic antigen, white blood cell count, neutrophil count, and C reactive protein in the observation group were significantly lower than those of the control group (P < 0.05), while quality of life (physiological status, social and family status, emotional status, functional status, public sector, additional attention, total score) scores in the observation group were significantly higher (P < 0.05). Times to bowel sound, postoperative exhaust, and postoperative defecation were shorter in the observation group than in the control group (P < 0.05). Postoperative hospitalization time in the observation group was shorter than that of control group (P < 0.05). Incidence of adverse reactions in the observation group was lower than that of the control group (P < 0.05). CONCLUSION: Jiawei Shengyang Yiwei soup combined with postoperative chemotherapy for colorectal cancer has significant clinical effects, and can relieve inflammatory reaction and improve quality of life. © 2016 Baishideng Publishing Group Inc. All rights reserved.
He A.-B.,The Fifth Hospital of Wuhan City |
Wang Q.,The Fifth Hospital of Wuhan City |
Luo Y.-X.,The Fifth Hospital of Wuhan City |
Tong W.-X.,The Fifth Hospital of Wuhan City |
Liu A.-H.,The Fifth Hospital of Wuhan City
Journal of Practical Oncology | Year: 2012
To investigate the efficacy and adverse reactions of Kanglaite (KLT) injection combined with docetaxel and oxaliplatin in treatment of advanced non-small cell lung cancer (NSCLC). Seventy-two patients with stage III~IV NSCLC were randomly divided into two groups: 40 patients received KLT combined with docetaxel and oxaliplatin (combined treatment group) and 32 patients were treated with docetaxel and oxaliplatin alone (control group). The short-term response rate of combined treatment group was 50.0% and that of control group was 37.5%; there was no statistically significant difference between two groups (P=0.139). The quality of life in combined treatment group was better than that in control group (P=0.003). Similarly, combined treatment group was better than control group in improving body weight (P=0.009). The incidence of the garde II or above bone marrow suppression and neurotoxicity in combined treatment group were significantly lower than those in control group (P=0.047, P=0.027). KLT injection with docetaxel and oxaliplatin in treatment of advanced NSCLC can improve the efficacy and reduce the toxicity of chemotherapy, which is worth of clinical application.
Gao Q.,Wuhan University |
Zhou J.,Wuhan University |
Yao C.,The Fifth Hospital of Wuhan City
Medical Journal of Wuhan University | Year: 2013
Objective: To evaluate the effect of Eltrombopag on idiopathic thrombocytopenic purpura (ITP) and the safety of Eltrombopag. Methods: PubMed, Wanfang, VIP, CNKI, and CBM-disc databases from establishment to 10th Oct. 2011 about randomized controlled trials (RCTs) of Eltrombopag in the treatment of ITP disease were collected, and meta-analysis was performed. Results: After the titles and abstracts were read, four trials which included 451 patients met the inclusion criteria. The result of meta-analysis showed the total effective rate in placebo group was worse than in Eltrombopag group (RR=3.47, 95%CI [2.45,4.91]). Adverse events rates of the two groups were similar (RR=1.16, 95%CI [0.78,1.73]]. Compared with placebo, Eltrombopag decreased the risk of bleeding (RR=0.82, 95%CI [0.73, 0.92]. Conclusion: On the aspect of treating ITP, Eltrombopag is more effective and safe than placebo.
Wu L.,Leshan Vocational and Technical College |
Lei W.,Leshan Vocational and Technical College |
Sheng T.,Leshan Vocational and Technical College |
You H.,The Fifth Hospital of Wuhan City |
And 2 more authors.
Medical Journal of Wuhan University | Year: 2015
Objective: To understand the anatomical characteristics of the sulcus intertubercularis and its clinical significance. Methods: The Helical CT technique was adopted to measure upper humeral sulcus intertubercularis of 30 volunteers. Results: Sulcus intertubercularis can be clearly shown with VRT. Medical wall angle and open angle are significantly different between the left and right sides of the humeral sulcus intertubercular (P<0.05), but width and depth did not show this difference (P>0.05). Conclusion: Medial wall angle and open angle are side-based different, when conducting arthroscopic surgical reconstruction of humeral sulcus, these factors mentioned above should be considered. ©, 2015, Editorial Board of Medical Journal of Wuhan University. All right reserved.