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Feng X.-Y.,The Fifth Central Hospital of Tianjin | Yin H.,The Fifth Central Hospital of Tianjin
International Journal of Ophthalmology | Year: 2011

AIM: To analyze the change of intraocular pressure(IOP) with ocular contusion. METHODS: A total of 181 cases were diagnosed with ocular contusion, the IOP > 24mmHg was regarded as ocular hypertension and the IOP < 10mmHg was regarded as ocular hypotension; the causes of abnormal IOP were classified and analyzed. RESULTS: Totally 120 cases (66.3%) in 181 cases of ocular contusion were of abnormal IOP: 98 cases(81.7%) of 120 cases were of ocular hypertension, 22 cases (18.3%) were of ocular hypotension. Clinical findings: the IOP after ocular contusion was associated with many complications, including hyphema, vitreous hemorrhage, mydriasis, iridodialysis, recession of anterior chamber angle, lens dislocation, vitreous body rush into anterior chamber, retinal concussion, detachment of ciliary body, etc. CONCLUSION: Ocular contusion can cause abnormal intraocular pressure, therefore ophthalmologist should think highly of it.


Feng X.-Y.,The Fifth Central Hospital of Tianjin | Zhao S.-L.,The Fifth Central Hospital of Tianjin
International Journal of Ophthalmology | Year: 2011

AIM: To explore the effect of paracentesis of anterior chamber combined laser peripheral iridectomy (LPI) in treatment of acute attack of primary angle-closure glaucoma. METHODS: Totally 36 cases 40 eyes of acute attack of primary angle-closure glaucoma were divided into two groups. The combined therapy group was treated by paracentesis of anterior chamber combined LPI, the control group was treated by medicine that could decrease IOP, then intraocular pressure (IOP), anterior chamber angle and the percentage of acute attack stopping and trabeculectomy were observed. RESULTS: The rate of acute attack stopping was 89% in paracentesis of anterior chamber combined LPI group, and 38% (P < 0.05) in control group; In therapy group the rate of trabeculectomy was 32%, in control group it was 76% (P < 0.05). CONCLUSION: The paracentesis of anterior chamber combined LPI have show it's better efficacy in patients of acute attack of primary angle-closure glaucoma. It can quickly open the closed angle, control IOP. So it can increase the percentage of acute attack stopping and decrease the rate of trabeculectomy.


Zheng L.,The Fifth Central Hospital of Tianjin | Du X.,The Fifth Central Hospital of Tianjin
Cell Biochemistry and Biophysics | Year: 2014

Non-steroidal anti-inflammatory drugs (NSAIDs) are frequently used to alleviate pain of the patients who suffer from inflammatory conditions like rheumatoid arthritis, osteoarthritis, and other painful conditions like gout. This class of drugs works by blocking cyclooxgenases which in turn block the prostaglandin production in the body. Most often, NSAIDs and antihypertensive drugs are used at the same time, and their use increases with increasing age. Moreover, hypertension and arthritis are common in the elderly patients requiring pharmacological managements. An ample amount of studies put forth evidence that NSAIDs reduce the efficiency of antihypertensive drugs plus aggravate pre-existing hypertension or make the individuals prone to develop high blood pressure through renal dysfunction. This review will help doctors to consider the effects and risk factors of concomitant prescription of NSAIDs and hypertensive drugs. © 2013 Springer Science+Business Media New York.


Zheng L.,The Fifth Central Hospital of Tianjin | Du X.,The Fifth Central Hospital of Tianjin
Cell Biochemistry and Biophysics | Year: 2014

Excessive right ventricular apex pacing has significant adverse effects on the cardiac function and hence, it is necessary to clinically optimize pacing parameters and advocate suitable physiological pacing to safeguard the cardiac function after pacemaker implant. Minimizing ventricular pacing is an atrioventricular node priority function, to encourage ventricular self conduction and to reduce unnecessary right ventricular pacing. Minimized ventricular pacing reduces ventricular pacing by encouraging self atrioventricular conduction function and extending the AV interval. This study is a prospective cohort study to evaluate the changes of cardiac function in patients and serum amino-terminal natriuretic peptide (NT-proBNP) before and after pacing, and the risk of atrial fibrillation with different CUM% VP. The study has shown that the cardiac function will deteriorate with an increase in pacing rate. © 2013 Springer Science+Business Media New York.


Zheng L.,The Fifth Central Hospital of Tianjin | Jia X.,The Fifth Central Hospital of Tianjin | Zhang C.,The Fifth Central Hospital of Tianjin | Wang D.,The Fifth Central Hospital of Tianjin | And 3 more authors.
American Journal of Translational Research | Year: 2015

Ang II/JAK/STAT3 signaling pathway is known to be involved in atrial remodeling associated with development and progression of atrial fibrillation. In the present study, we used in vivo animal model and human atrial specimens to further characterize the role of this pathway in the atrial structural remodeling. We observed an elevated level of Ang II in the atrial samples of AF patients. This increase in Ang II was accompanied by increased expression of collagens I and III, MMP1, MMP2 and elevated phosphorylation of STAT3. Using rat models, we demonstrated that Ang II infusion induced profound changes in the level of apoptosis, expression of collagen subtypes I and III, caspase-3, caspase-8, MMP1, MMP2 and redistribution of cytochrome C. The data further support the key role of Ang II in the development of AF and highlight the specific mechanisms and changes associated with this process. © 2015 E-Century Publishing Corporation. All rights reserved.

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