Luo S.-F.,The Fifth Center Hospital of Tianjin |
Qu Y.,The Fifth Center Hospital of Tianjin |
Chen J.,Hubei University |
Li P.,The Fifth Center Hospital of Tianjin
Chinese Journal of Tissue Engineering Research | Year: 2014
BACKGROUND: There is little attention focused on the effect of isokinetic testing about the variation of angular velocity on pain and muscle strength in the evaluation of curative effect of McConnell taping. OBJECTIVE: To evaluate the changes of quadriceps muscle strength and perceived pain levels in patients with patellofemoral pain syndrome before and after corrective McConnell taping in isokinetic testing. METHODS: A total of 34 patients with patellofemoral pain syndrome were evaluated in isokinetic testing for concentric contraction muscular strength, including the maximum torque, the total work, and the average work in 60 (°)/s and 180 (°)/s angular velocity, before and after the interventions of McConnell taping. The visual analogue scale scores were recorded. RESULTS AND CONCLUSION: The visual analogue scale scores were slightly decreased in angular velocity of 60 (°)/s after obturation when compared to before obturation (P > 0.05), while the scores were significantly decreased in angular velocity of 180 (°)/s (P < 0.05). The maximum torque, the total work, and the average work were slightly increased after obturation, but showed no significant difference in angular velocity of 60 (°)/s (P > 0.05), while significantly increased in 180 (°)/s angular velocity (P < 0.05). McConnell taping significantly improves the curative effect in patients with patellofemoral pain syndrome under low load joint movement.
Zhu S.-W.,Tianjin Medical University |
Zhu S.-W.,The Fifth Center Hospital of Tianjin |
Li J.-P.,The Fifth Center Hospital of Tianjin |
Ma X.-L.,The Fifth Center Hospital of Tianjin |
And 4 more authors.
Asian Pacific Journal of Cancer Prevention | Year: 2015
Osteosarcoma is the most common primary bone tumor in humans, especially in childhood. However, the genetic etiology for its pathogenesis remains elusive. It is known that microRNAs (miRNAs) are involved in the development of tumor progression. Here we show that microRNA-9 (miR-9) is a potential oncogene upregulated in osteosarcoma cells. Knockdown of miR-9 in osteosarcoma resulted in suppressed colony formation and cell proliferation. Further study identified GCIP, a Grap2 and cyclin D interacting protein, as a direct target of miR- 9. In addition, GCIP overexpression activated retinoblastoma 1 (Rb) and suppressed E2F transcriptional target expression in osteosarcoma cells. Moreover, GCIP depletion reversed miR-9 knockdown induced colony formation and cell proliferation suppression. In sum, these results highlight the importance of miR-9 as an oncogene in regulating the proliferation of osteosarcoma by directly targeting GCIP and may provide new insights into the pathogenesis of osteosarcoma.