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Li J.,The General Hospital of Beijing Military Command | Yang G.-Z.,The General Hospital of Beijing Military Command | Gao L.-X.,The General Hospital of Beijing Military Command | Yan W.-X.,The Eighth Peoples Hospital of Qingdao City | And 2 more authors.
Experimental and Therapeutic Medicine | Year: 2012

In 1987, Carney et al described a rare thyroid tumor termed hyalinizing trabecular adenoma presenting characteristics consisting of a trabecular growth pattern and hyalinizing stroma. In subsequent reports, the observed nuclear features and RET alterations led this tumor to be linked to papillary carcinoma. Subsequent reports concerning hyalinizing trabecular carcinoma further complicated its classification. To avoid uncertainties, the definition of hyalinizing trabecular tumor (HTT) is more widely used. Herein, a case of HTT is reported in detail, and the circumstances are also discussed. HTT is thought to be particularly differentiated from papillary carcinoma despite the identical high frequency of nuclear grooves and cytoplasmic inclusions, and MIB-1-positive staining is one of the most accurate diagnostic methods due to the distinct membrane-positive pattern noted in HTT. It is believed that most HTTs are benign and lobectomy is the standard treatment. Pathologists should offer surgeons information concerning diagnosis overlapping with effective treatment.

Liu S.-Q.,The Eighth Peoples Hospital of Qingdao City | Tian R.-Y.,The Eighth Peoples Hospital of Qingdao City | Liu M.,The Eighth Peoples Hospital of Qingdao City
Journal of Practical Oncology | Year: 2012

Objective: To investigate the correlations of high-risk HPV load of CIN to the abnormal cytology after surgery. Methods: 205 CIN patients received high-risk HPV load detection using hybrid capture II(HC-II)and thin-layer liquid based-cytology(LCT) before operations and were followed up for 6-8 months. Results: After follow-up of 6-8 months, 25 patients were found abnormal cytological smear again, whose HPV loads were all over 1000 RLU/CO berore operation. The abnormal cytology after operation related to the high-risk HPV load (P<0.01), had no relation to CIN grades(P<0.01). Conclusion: HR-HPV high load(the viral load of over 1000 RLU/CO) can increase the risk of surgical recurrence.

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