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Zahra E.,Jahrom University of Medical Sciences | Zahra E.,Islamic Azad University at Jahrom | Jahromi Hossein K.,Jahrom University of Medical Sciences | Jahromi Hossein K.,Islamic Azad University at Jahrom | And 5 more authors.
Advances in Environmental Biology | Year: 2013

Introduction: Raloxifene is from SERM drugs groups (selective estrogen receptor modulators). These drugs in some tissues have similar effects of estrogen (agonist) and prevent the effects of estrogen in other tissues (antagonistic). In this study, the effects of raloxifene on the factors of blood urea nitrogen, uric acid and creatinine in rats were measured. Methods: 40 female Wistar rats were divided randomly into 5 groups. The first group (control group) did not receive any medication. The second group (sham group) only distilled water injected. Experimental group 1 received raloxifene 5 mg/kg daily, experimental group 2 received raloxifene 10 mg/kg, and experimental group 3 received raloxifene 20 mg/kg that all was based on body weight and were received intraperitoneally. At the end of 30 days, the rats were bled and concentration of blood serum of urea nitrogen, uric acid and creatinine were measured. Data were analyzed using SPSS software version 18. Results: The results show that the concentration of creatinine in experimental groups 1, 2 and 3 showed a significant increase compared to the control group. Concentrations of Blood urea nitrogen and uric acid have no significant change compared to control group. Conclusion: We may conclude that raloxifene in low rates, causes changes in concentration of Renal factors. © 2013 AENSI Publisher All rights reserved.


Daneshi A.,The Departmant General of Yasuj Province Education | Daneshi A.,Jahrom University of Medical Sciences | Hossein K.J.,Jahrom University of Medical Sciences | Hossein K.J.,Islamic Azad University at Jahrom | And 5 more authors.
Advances in Environmental Biology | Year: 2013

Introduction and Objectives: Harmala plant has activations of anti-bacterial, anti-fungal and anti-tumor, and inhibit Monoamine oxidase enzyme, stimulate nervous system and modulate activation of Endocrine. The aim of this study was to investigate the effect of harmala seed extract on the levels of hormones of pituitary-thyroid and liver enzymes. Materials and methods: This research is an experimental study that was done on 50 adult male Wistar rats. In this study, animals were divided into 5 groups. The control group did not receive any treatments, the sham group for 14 consecutive days received orally 1 ml of distilled water and experimental groups for 14 consecutive days received respectively 90 mg/kg, 180 mg/kg and 270 mg/kg harmala seed extract that was given orally and on the fifteenth day, stimulating hormones concentration of thyroid, thyroxine and triiodothyronine and liver enzymes were measured and the results analyzed using SPSS software and ANOVA test. Results: Harmala seed extract at the minimum and maximum doses significantly reduced the rate of thyroid stimulating hormone, and in medium and maximum doses significantly reduced the rate of thyroxine and triiodothyronine, but body weight and liver enzymes did not show significant changes (P<0.05). Conclusion: The results indicate that the harmala seed extract can be used in the treatment of hyperthyroidism. © 2013 AENSI Publisher All rights reserved.

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