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Patricia L.,The Computer Way
WCCCE 2011 - Proceedings of the 16th Western Canadian Conference on Computing Education | Year: 2011

In a degree where technical skills are mainly emphasized, it is often difficult to have students realize that they also need some soft skills to successfully create useful software. Often students leave an HCI course with some ideas of what HCI is about, without really appreciating its impact, or its usefulness. However, as universal usability [6] is becoming more and more prevalent, such understanding is crucial. In this paper we describe an experiment in which service learning (or community service learning) is used as a means to fully engage students in a usability study through the re-design of a website as part of their HCI course requirement. After describing in details the constraints of the project, I present what has been discovered throughout the term, and discuss some of the challenges and advantages of service learning. © 2011 ACM. Source


Rosenbloom P.S.,The Computer Way
Proceedings of the 10th International Conference on Cognitive Modeling, ICCM 2010 | Year: 2010

A prototypical cognitive architecture defines a memory architecture embodying forms of both procedural and declarative memory, plus their interaction. Reengineering such a dual architecture on a common foundation of graphical models enables a better understanding of both the substantial commonalities between procedural and declarative memory and the subtle differences that endow each with its own special character. It also opens the way towards blended capabilities that go beyond existing architectural memories. Source


Sandoo A.,The Dudley Group NHS Trust | Sandoo A.,University of Birmingham | Chanchlani N.,The Dudley Group NHS Trust | Hodson J.,The Computer Way | And 5 more authors.
Arthritis Research and Therapy | Year: 2013

Introduction: Patients with rheumatoid arthritis (RA) are at an increased risk for cardiovascular disease (CVD). An early manifestation of CVD is endothelial dysfunction which can lead to functional and morphological vascular abnormalities. Classical CVD risk factors and inflammation are both implicated in causing endothelial dysfunction in RA. The objective of the present study was to examine the effect of baseline inflammation, cumulative inflammation, and classical CVD risk factors on the vasculature following a six-year follow-up period. Methods: A total of 201 RA patients (155 females, median age (25th to 75th percentile): 61 years (53 to 67)) were examined at baseline (2006) for presence of classical CVD risk factors and determination of inflammation using C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR). At follow-up (2012) patients underwent assessments of microvascular and macrovascular endothelium-dependent and endothelium-independent function, along with assessment of carotid atherosclerosis. The CRP and ESR were recorded from the baseline study visit to the follow-up visit for each patient to calculate cumulative inflammatory burden. Results: Classical CVD risk factors, but not RA disease-related inflammation, predicted microvascular endothelium-dependent and endothelium-independent function, macrovascular endothelium-independent function and carotid atherosclerosis. These findings were similar in a sub-group of patients free from CVD, and not receiving non-steroidal anti-inflammatory drugs, cyclooxygenase 2 inhibitors or biologics. Cumulative inflammation was not associated with microvascular and macrovascular endothelial function, but a weak association was apparent between area under the curve for CRP and carotid atherosclerosis. Conclusions: Classical CVD risk factors may be better long-term predictors of vascular function and morphology than systemic disease-related inflammation in patients with RA. Further studies are needed to confirm if assessments of vascular function and morphology are predictive of long-term CV outcomes in RA. © 2013 Sandoo et al.; licensee BioMed Central Ltd. Source


Sandoo A.,Dudley Group of Hospitals NHS Trust | Sandoo A.,University of Birmingham | Hodson J.,The Computer Way | Douglas K.M.,Dudley Group of Hospitals NHS Trust | And 4 more authors.
Arthritis Research and Therapy | Year: 2013

Introduction: Patients with rheumatoid arthritis (RA) are at an increased risk for cardiovascular disease (CVD). One of the earliest manifestations of CVD is endothelial dysfunction (ED), which can lead to functional and morphological vascular abnormalities. Several non-invasive assessments of vascular function and morphology can be utilised to assess vascular health, but little is known about the association between each of these assessments in patients with RA, and they tend to be used interchangeably in the literature. The objective of the present study was to examine associations between measures of vascular function and morphology in patients with RA. Methods: A total of 201 RA patients (155 females, median (25thto 75thpercentile) age: 67 (59 to 73)) underwent assessments of microvascular endothelium-dependent and endothelium-independent function (laser Doppler imaging with iontophoresis of acetylcholine and sodium-nitroprusside respectively), macrovascular endothelium-dependent and endothelium-independent function (flow-mediated dilatation and glyceryl-trinitrate-mediated dilation respectively), and vascular morphology (pulse wave analysis, carotid intima-media thickness (cIMT), and carotid plaque). Results: Spearman's correlations revealed that from the functional parameters, only macrovascular endothelium-independent function was inversely associated with cIMT (-0.294 (P < 0.001)) after applying the Bonferroni correction for multiple comparisons. For carotid plaque, t tests showed that macrovascular endothelium-independent function was lower in patients with plaque than without (15.5 ± 8.3 vs. 23.1 ± 9.1%, P = 0.002, respectively).Conclusions: With the exception of macrovascular endothelium-independent function, all other measures of vascular function were not associated with vascular morphology. This suggests that different assessments of vascular function and morphology in patients with RA reflect quite distinct mechanisms and phases of the atherosclerotic process and should not be used interchangeably. © 2013 Sandoo et al.; licensee BioMed Central Ltd. Source


Mondal S.,3187 University Way Okanagan | Lucet Y.,The Computer Way | Hare W.,3187 University Way Okanagan
Computers and Operations Research | Year: 2015

Finding an optimal alignment connecting two end-points in a specified corridor is a complex problem that requires solving three interrelated sub-problems, namely the horizontal alignment, vertical alignment and earthwork optimization problems. In this research, we developed a novel bi-level optimization model combining those three problems. In the outer level of the model, we optimize the horizontal alignment and in the inner level of the model a vertical alignment optimization problem considering earthwork allocation is solved for a fixed horizontal alignment. Derivative-free optimization algorithms are used to solve the outer problem. The result of our model gives an optimal horizontal alignment in the form of a linear-circular curve and an optimal vertical alignment in the form of a quadratic spline. Our model is tested on real-life data. The numerical results show that our approach improves the road alignment designed by civil engineers by 27% on average, resulting in potentially millions of dollars of savings. © 2015 Elsevier Ltd. Source

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