Sandoo A.,Russells Hall Hospital |
Sandoo A.,University of Birmingham |
Chanchlani N.,Russells Hall Hospital |
Hodson J.,The Computer Way |
And 5 more authors.
Arthritis Research and Therapy | Year: 2013
Introduction: Patients with rheumatoid arthritis (RA) are at an increased risk for cardiovascular disease (CVD). An early manifestation of CVD is endothelial dysfunction which can lead to functional and morphological vascular abnormalities. Classical CVD risk factors and inflammation are both implicated in causing endothelial dysfunction in RA. The objective of the present study was to examine the effect of baseline inflammation, cumulative inflammation, and classical CVD risk factors on the vasculature following a six-year follow-up period. Methods: A total of 201 RA patients (155 females, median age (25th to 75th percentile): 61 years (53 to 67)) were examined at baseline (2006) for presence of classical CVD risk factors and determination of inflammation using C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR). At follow-up (2012) patients underwent assessments of microvascular and macrovascular endothelium-dependent and endothelium-independent function, along with assessment of carotid atherosclerosis. The CRP and ESR were recorded from the baseline study visit to the follow-up visit for each patient to calculate cumulative inflammatory burden. Results: Classical CVD risk factors, but not RA disease-related inflammation, predicted microvascular endothelium-dependent and endothelium-independent function, macrovascular endothelium-independent function and carotid atherosclerosis. These findings were similar in a sub-group of patients free from CVD, and not receiving non-steroidal anti-inflammatory drugs, cyclooxygenase 2 inhibitors or biologics. Cumulative inflammation was not associated with microvascular and macrovascular endothelial function, but a weak association was apparent between area under the curve for CRP and carotid atherosclerosis. Conclusions: Classical CVD risk factors may be better long-term predictors of vascular function and morphology than systemic disease-related inflammation in patients with RA. Further studies are needed to confirm if assessments of vascular function and morphology are predictive of long-term CV outcomes in RA. © 2013 Sandoo et al.; licensee BioMed Central Ltd.
Anvik J.,Central Washington University |
Anvik J.,The Computer Way |
Murphy G.C.,University of British Columbia
ACM Transactions on Software Engineering and Methodology | Year: 2011
A key collaborative hub for many software development projects is the bug report repository. Although its use can improve the software development process in a number of ways, reports added to the repository need to be triaged. A triager determines if a report is meaningful. Meaningful reports are then organized for integration into the project's development process. To assist triagers with their work, this article presents a machine learning approach to create recommenders that assist with a variety of decisions aimed at streamlining the development process. The recommenders created with this approach are accurate; for instance, recommenders for which developer to assign a report that we have created using this approach have a precision between 70% and 98% over five open source projects. As the configuration of a recommender for a particular project can require substantial effort and be time consuming, we also present an approach to assist the configuration of such recommenders that significantly lowers the cost of putting a recommender in place for a project. We show that recommenders for which developer should fix a bug can be quickly configured with this approach and that the configured recommenders are within 15% precision of hand-tuned developer recommenders. © 2011 ACM.
Patel A.A.,The Computer Way |
Dharwa Y.N.,Ganpat University
ACM International Conference Proceeding Series | Year: 2016
The emergence of personalization in new generation e-commerce and power shift towards consumers enforces incorporation of recommendation system. To implement that, an innovative user web-interactions models and novel recommendation strategy will be in demand. This research work looks for innovative approach for on-line mobile trades, which integrate knowledge of expert with product specifications to develop hybrid personalized recommendations system. The uniqueness of this work includes advanced user-web interaction strategies, need based mobile selections criteria and added gain of expert knowledge. The very well known, fuzzy logic technique had implied to compute similarity matching along with flexibility. Experimental results demonstrate the competence test of system by getting feedback about customer satisfaction against various perspectives of systems performance. The proposed research work could also provide guidelines to deal with design challenge for personalized recommendations model for many other domains. © 2016 ACM.
Altschuller S.,Iona College |
Benbunan-Fich R.,The Computer Way
Journal of Computer-Mediated Communication | Year: 2010
This research explores the communication process variables that potentially determine trust and performance quality in ad hoc virtual teams to better inform the choice of communication media for virtual groups engaged in decision-making tasks. Results of a survey indicate that virtual copresence is significantly correlated with intrateam trust and the performance quality that teams achieve. Results also accentuate the prominent role of trust in the virtual collaborative decision-making process; they indicate that trust mediates the relationship between virtual copresence and performance. It is therefore recommended that the efforts related to the design and adoption of communication systems for decision making teams strongly consider that virtual copresence potentially promotes both high levels of trust and high quality performance in virtual teams. © 2010 International Communication Association.
Khmelevsky Y.,Okanagan College |
Khmelevsky Y.,The Computer Way
Proceedings of the WCCCE 2016 - The 21st Western Canadian Conference on Computing Education | Year: 2016
In this paper we discuss ten years of teaching of "Projects in Computer Science" (COSC 224), "Software Engineering" with the following "Software Engineering Project" capstone projects (COSC 470 and COSC 471 respectfully) at the Computer Science Department of Okanagan College (OC). We included "Object-Oriented Systems Analysis and Design" (COSC 236) course in the discussion, which was used for the initial systems analysis and design in the Fall before the project development in COSC 224 in the Winter, as it was suggested by the students in several anonymous program reviews. Also we provide retrospective analysis and evaluation of capstone projects, starting from very small artificial projects, then moving on to projects with international industrial sponsors and sponsors from universities. Then, after many discussions with the students and within our department we decided to work with local small companies instead of large international corporations and universities. Starting from 2013 many capstone projects in both COSC 236/224 and COSC 470/471 supported applied research projects at Computer Science department, especially those that were related to the projects supported by the "Natural Sciences and Engineering Research Council of Canada (NSERC)" in 2014 - 2016. © 2016 ACM.
Patricia L.,The Computer Way
WCCCE 2011 - Proceedings of the 16th Western Canadian Conference on Computing Education | Year: 2011
In a degree where technical skills are mainly emphasized, it is often difficult to have students realize that they also need some soft skills to successfully create useful software. Often students leave an HCI course with some ideas of what HCI is about, without really appreciating its impact, or its usefulness. However, as universal usability  is becoming more and more prevalent, such understanding is crucial. In this paper we describe an experiment in which service learning (or community service learning) is used as a means to fully engage students in a usability study through the re-design of a website as part of their HCI course requirement. After describing in details the constraints of the project, I present what has been discovered throughout the term, and discuss some of the challenges and advantages of service learning. © 2011 ACM.
Rosenbloom P.S.,The Computer Way
Proceedings of the 10th International Conference on Cognitive Modeling, ICCM 2010 | Year: 2010
A prototypical cognitive architecture defines a memory architecture embodying forms of both procedural and declarative memory, plus their interaction. Reengineering such a dual architecture on a common foundation of graphical models enables a better understanding of both the substantial commonalities between procedural and declarative memory and the subtle differences that endow each with its own special character. It also opens the way towards blended capabilities that go beyond existing architectural memories.
Mondal S.,3187 University Way Okanagan |
Lucet Y.,The Computer Way |
Hare W.,3187 University Way Okanagan
Computers and Operations Research | Year: 2015
Finding an optimal alignment connecting two end-points in a specified corridor is a complex problem that requires solving three interrelated sub-problems, namely the horizontal alignment, vertical alignment and earthwork optimization problems. In this research, we developed a novel bi-level optimization model combining those three problems. In the outer level of the model, we optimize the horizontal alignment and in the inner level of the model a vertical alignment optimization problem considering earthwork allocation is solved for a fixed horizontal alignment. Derivative-free optimization algorithms are used to solve the outer problem. The result of our model gives an optimal horizontal alignment in the form of a linear-circular curve and an optimal vertical alignment in the form of a quadratic spline. Our model is tested on real-life data. The numerical results show that our approach improves the road alignment designed by civil engineers by 27% on average, resulting in potentially millions of dollars of savings. © 2015 Elsevier Ltd.
Chen C.-W.,The Computer Way |
Koufaris M.,The Computer Way
European Journal of Information Systems | Year: 2015
There is considerable research on how Decision Support Systems (DSSs) enable users to make better decisions. However, there is less focus on the possibility that some of their features may introduce biases and encourage suboptimal user behavior. We report on an experimental study that examines three DSS features that are generally considered beneficial to the user: the degree of choice the system provides to the user, the presence of competition among concurrent users, and the use of training to increase system familiarity. We hypothesize that the three DSS features may increase risky behavior (measured as the amount invested in a stock investment task with random outcomes) and overconfidence, conceptualized as the illusion of control, the phenomenon whereby people believe their chances of success at a task are greater than would be warranted by objective analysis. Our results confirm the effects of the three DSS features on risky behavior but only degree of choice impacts overconfidence. Moreover, overconfidence does not appear to mediate the impact of the DSS features on risky behavior. Finally, we hypothesize and confirm that, controlling for the effect of actual performance, overconfidence increases user satisfaction with the decision-making process and outcome. © 2015 Operational Research Society Ltd.