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Zheng X.,Northwestern University | Lee S.,Northwestern University | Selvarangan R.,The Childrens Mercy Hospitals and Clinics | Qin X.,Seattle Childrens Hospital | And 9 more authors.
Emerging Infectious Diseases | Year: 2015

Macrolide-resistant Mycoplasma pneumoniae (MRMP) is highly prevalent in Asia and is now being reported from Europe. Few data on MRMP are available in the United States. Using genotypic and phenotypic methods, we detected high-level MRMP in 13.2% of 91 M. pneumoniae–positive specimens from 6 US locations. © 2015, Centers for Disease Control and Prevention (CDC). All rights reserved. Source

Brown R.A.,Butler Hospital | Brown R.A.,Brown University | Abrantes A.M.,Butler Hospital | Abrantes A.M.,Brown University | And 14 more authors.
Journal of Substance Abuse Treatment | Year: 2015

Substance use among adolescents with one or more psychiatric disorders is a significant public health concern. In this study, 151 psychiatrically hospitalized adolescents, ages 13-17 with comorbid psychiatric and substance use disorders, were randomized to a two-session Motivational Interviewing intervention to reduce substance use plus treatment as usual (MI) vs. treatment as usual only (TAU). Results indicated that the MI group had a longer latency to first use of any substance following hospital discharge relative to TAU (36 days versus 11 days). Adolescents who received MI also reported less total use of substances and less use of marijuana during the first 6 months post-discharge, although this effect was not significant across 12 months. Finally, MI was associated with a significant reduction in rule-breaking behaviors at 6-month follow-up. Future directions are discussed, including means of extending effects beyond 6 months and dissemination of the intervention to community-based settings. © 2015 Elsevier Inc. Source

Abdel-Rahman S.M.,The Childrens Mercy Hospitals and Clinics | Ridge A.L.,The Childrens Mercy Hospitals and Clinics
Open Medical Devices Journal | Year: 2012

There exist a number of pediatric health care settings wherein time and/or resource constraints do not permit care providers to reliably assess children's weight. This study describes the development and validation of a pediatric weight estimation strategy that addresses the limitations of currently available weight estimation methods. Demographic and anthropometric data on children 2 months to 16 years of age were extracted from the National Health and Nutrition Examination Survey. Datasets were randomly assigned into a method development set (n=17,328) and a method validation set (n=1,938). Humeral length and mid-upper arm circumference were used to develop a weight estimation method. The predictive performance of this method was evaluated and compared with the performance of 13 previously published weight estimation methods. We also developed a measurement device that performs both measurements simultaneously requiring simple addition and no external references to arrive at the weight estimate. The method developed in this study (Mercy method) outperformed the 13 other published methods when evaluated by goodness-of-fit (r2=0.98 vs. 0.69 to 0.87; slope=0.97 vs. 0.43 to 0.96; intercept 0.9 vs. 3.1 to 11.8), mean error (-0.40 kg vs.-10.88 to 2.23), mean percentage error (-0.46% vs. -16.84 to 3.51), root mean square error (3.65 kg vs. 3.42 to 16.96) and percentage of children in agreement within 10% of actual weight (79% vs. 17.8 to 45.3). The Mercy method represents a significant improvement over existing age-based, length-based and habitus-based weight estimation strategies. © Abdel-Rahman and Ridge; Licensee Bentham Open. Source

Preuett B.L.,The Childrens Mercy Hospitals and Clinics | Schuenemann E.,The Childrens Mercy Hospitals and Clinics | Brown J.T.,The Childrens Mercy Hospitals and Clinics | Kovac M.E.,The Childrens Mercy Hospitals and Clinics | And 3 more authors.
Fungal Biology | Year: 2010

Trichophyton tonsurans (TT) and Trichophyton equinum (TE) are two closely related dermatophytes with very different host preferences. This study was designed to examine the genetic and transcript level variations of secreted enzymes between TT and TE. Thirty-one genes representing 10 gene families were selected for comparison and complete genomic and cDNA sequences were elucidated. Sequence analyses of the selected genes identified 104 polymorphisms between the two dermatophytes, 37 of which are expected to encode changes in their polypeptide sequence. Quantitative RT-PCR was used to examine the differences in levels of transcript between TT and TE grown over 14. d in aqueous keratin medium. Differences in transcript expression between TT and TE were gene specific and ranged from 1.1-fold to 33-fold. Intra-specific variability across all genes ranged from 41. % to 250. %. Despite their overall genetic similarity, TT and TE exhibit a moderate degree of variability in the genomic make-up of their secreted enzymes and the extent to which they are transcribed when grown in an aqueous keratin medium. Such differences may contribute to how these genetically similar organisms have adapted to infect divergent host organisms. © 2010 The British Mycological Society. Source

Hughes S.S.,The Childrens Mercy Hospitals and Clinics | Welsh H.I.,The Childrens Mercy Hospitals and Clinics | Safina N.P.,The Childrens Mercy Hospitals and Clinics | Bejaoui K.,Prevention Genetics | Ardinger H.H.,The Childrens Mercy Hospitals and Clinics
American Journal of Medical Genetics, Part A | Year: 2014

CHARGE syndrome is an autosomal dominant malformation syndrome associated with mutations in CHD7. The condition is typically sporadic with few familial cases reported. The diagnosis of CHARGE syndrome is based on a combination of major and minor criteria comprised of structural and functional abnormalities, most of which are part of the original CHARGE acronym, although additional anomalies have been added. To date, family history has not been considered in the diagnostic criteria. Here we report a family with a previously unreported missense mutation in exon 31 of CHD7, in which family history played a role in the diagnosis of CHARGE syndrome. Given the tremendous phenotypic variability and the dominant nature of CHARGE syndrome, we propose that family history be included as a major diagnostic criterion. A positive family history would include any individual with an apparently isolated unilateral major CHARGE anomaly or someone with a few of the minor features. Our cases support this proposal; had family history not been considered in this case, CHD7 testing might not have been pursued, leading to incomplete medical follow-up and erroneous genetic counseling. Additionally, with the increased incidence of orofacial clefting in this family, as well as in the literature, we suggest that cleft lip and/or palate be added to the major diagnostic criteria for CHARGE syndrome. © 2013 Wiley Periodicals, Inc. Source

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