Time filter

Source Type

Xuzhou Jiangsu, China

Li Z.P.,The Central Hospital of Xuzhou
Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology | Year: 2013

To present 4 cases of hemophilic pseudotumor and to investigate the treatment outcome. Four cases of hemophilic pseudotumor were reviewed. The patients were treated by internal medicine combined with surgery and followed up for two years. The feature and diagnosis of the disease were analyzed and the treatment outcome was evaluated. All of the 4 cases were misdiagnosed with a history of bleeding before operation. One patient was bleeding after biopsy without replacement therapy. One patient was presented with gingival bleeding and anaemia. The final diagnosis of hemophilia A in all the 4 cases was confirmed by the blood test (VIII deficiency). After infusion of factor VIII, operation was performed on all cases. There was no recurrence after two years of follow-up. It should be aware of the rarely encountered disease which is prone to be misdiagnosed. Under factor-deficient replacement therapy, surgical management is the most effective way in preventing from bleeding and avoiding progressive expanding of pseudotumor. Source

Li W.,Soochow University of China | Liang R.-R.,Soochow University of China | Zhou C.,The Central Hospital of Xuzhou | Wu M.-Y.,Soochow University of China | And 15 more authors.
Cancer Cell International | Year: 2015

Objective: Angiogenesis is a critical step of breast cancer metastasis. Oncogenic Ras promotes the remodeling of cancer microenviroment. Tumor-associated macrophages (TAMs) are a prominent inflammatory cell population emerging in the microenviroment and facilitating the angiogenesis and metastasis. In the present study, we tried to investigate the relationship between the expression of Ras and infiltration of TAM, both of which could further promote angiogenesis. Methods: Expressions of Ras, CD68 and CD34 were assessed by immunohistochemistry. The infiltration of macrophages was evaluated by counting the number of CD68+ cells. Vessel endothelial cells were defined as CD34+ cells. Angiogenesis vascularity was defined by microvessel density (MVD) assay through counting the number of vessels per field counted in the area of highest vascular density. The Kaplan-Meier survival analysis was used to estimate the overall survival (OS). Macrophages were derived from monocytes in the presence of macrophage colony-stimulating-factor (MCSF). Breast cancer cells were treated with macrophage-conditioned medium (MCM) and tested the expressions of K-, H- and N-Ras by using realtime-PCR. Results: Ras positive status was correlated with ER, PR and Her-2 positivity, larger tumour size and lymph node metastasis, as well as higher TNM stages. A higher number of CD68+ cells was correlated with larger tumour size, higher TNM stages and Her-2 positivity. Both Ras positivity and infiltration of CD68+ macrophages correlated with poor OS. The number of CD68+ cells was positively correlated with the expression of Ras. Treatment with MCM did not up-regulate but repressed the expression of Ras. Both up-regulation of Ras and infiltration of TAMs correlated with increased MVD. Conclusion: Expression of Ras and infiltration of TAM were positively correlated, and both participated in angiogenesis. Elevated Ras could be responsible for the infiltration of TAM. © Li et al.; licensee BioMed Central. Source

An X.-L.,The Central Hospital of Xuzhou | Li C.-L.,The Central Hospital of Xuzhou
Cell Biochemistry and Biophysics | Year: 2014

This study aimed to identify risk factors for vascular cognitive impairment (VCI) in cerebral infarction patients. Associations between VCI and age, gender, blood pressure, lipid levels, glycosylated hemoglobin, atrial fibrillation, tobacco smoking, alcohol consumption, homocysteine (Hcy), and High-Sensitivity C-Reactive Protein (HS-CRP) were evaluated in patients with cerebral infarction (n = 300) using single factor analysis and multivariate logistic regression analysis. By single factor analysis, the age, glycosylated hemoglobin, atrial fibrillation, blood pressure, Hcy, HS-CRP, tobacco smoking, and alcohol consumption were significantly associated with VCI in these patients. By multivariate logistic regression analysis, the age, glycosylated hemoglobin, blood pressure, Hcy, and HS-CRP were revealed as independent risk factors. The age, glycosylated hemoglobin, blood pressure, Hcy, and HS-CRP can serve as predictive factors for VCI in patients with cerebral infarction. © 2014, Springer Science+Business Media New York. Source

Zhou C.,The Central Hospital of Xuzhou | Bu X.,The Central Hospital of Xuzhou | Li X.,The Central Hospital of Xuzhou | Liu L.,The Central Hospital of Xuzhou | And 3 more authors.
Cell Biochemistry and Biophysics | Year: 2015

We report here a case of nasal natural killer/T-cell lymphoma with metastasization into the pancreas. A 43-year-old Chinese female patient presented with right nasal obstruction and purulent rhinorrhea that lasted for the past half year and worsened gradually despite antibiotic medical treatment. Physical examination revealed a mass in the right nasal cavity and an enlarged lymph node in the right submandibular region. A PET/CT scan and immunostaining of the resectate led to a diagnosis of nasal natural killer/T-cell lymphoma, clinical stage IIE, and the International Prognostic Index score of 1. The patient received radiotherapy followed by four cycles of the CHOP chemotherapy. A complete remission was achieved, and the patient was disease-free for 9 months. On a subsequent follow-up, abdominal ultrasound scan, enhanced abdominal CT scan, and ultrasound-guided fine-needle aspiration biopsy revealed pancreatic metastasis secondary to nasal lymphoma. Radiotherapy (40 Gy) to the whole pancreas was done, followed by two courses of the SMILE regime chemotherapy, leading to a complete remission. At the moment, the patient is undergoing subsequent chemotherapy. © 2015, Springer Science+Business Media New York. Source

Discover hidden collaborations