The Central Hospital of Xuzhou

Xuzhou Jiangsu, China

The Central Hospital of Xuzhou

Xuzhou Jiangsu, China
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Sun W.-H.,The Central Hospital of Xuzhou | Hu C.-A.,The Central Hospital of Xuzhou | Chen G.,The Central Hospital of Xuzhou | Lyu L.-L.,The Central Hospital of Xuzhou
Chinese Journal of Interventional Imaging and Therapy | Year: 2015

Objective: To explore the method to locate the left atrial appendage (LAA) and the sequences of MR scan. Methods: Thirty patients were performed MR scan of LAA with Siemens Skyra 3.0T MR system. 2D black blood and (or) bright blood were used to obtain the standard level of LAA, then the images of LAA function with Cine-TrueFISP sequence and contrast medium filling and delay imaging of LAA with Dynamic-Turbo-FLASH sequence on the standard level of LAA were obtained. Both scan location and image quality were analyzed with workstation. Results: All 30 patients completed examination without heart rate control (26 cases hold breath and 4 cases free breathing). The average scan time was (19±5)min. The quality of 2D black blood HASTE sequence images were good in 25 cases, while 5 cases had blurred images for slow blood flow artifact and effect on diagnosis. With 2D bright blood TrueFISP sequences, the images of 28 cases matched the diagnosis, while the other finally matched the diagnosis after further scanning to reduce magnetic sensitive artifacts. All images of Cine-True-FISP sequence all satisfied diagnostic requiement. Images of dynamic-Turbo-FLASH sequence were all good. Images of IR-True-FISP sequences reached the needs of diagnostic requiement, including optimal images in 22 cases. Conclusion: Rely on the advantages of high SNR of 3.0T MR system, with multi-level and multi-dimensional positioning and a variety of fast imaging sequences, no matter patients hold breath or breath freely, even if without control of heart rate, images of LAA can be gotten satisfied. Copyright © 2015 by the Press of Chinese Journal of Medical Imaging and Technology.


Xia P.,the Central Hospital of Xuzhou | Xu Q.-S.,the Central Hospital of Xuzhou | Hao J.-M.,the Central Hospital of Xuzhou | Hu C.-A.,the Central Hospital of Xuzhou | And 3 more authors.
Chinese Journal of Medical Imaging Technology | Year: 2015

Objective: To evaluate the applicable value of temporal resolution-cardiac cycle curve in the multi-slice spiral CT coronary angiography (MSCTCA). Methods: Totally 126 patients undergoing MSCTCA with 320-slice spiral CT were enrolled. Optimum gantry rotation was chosen according to patient's heart rate, and scanning was done with three segment reconstruction algorithms. Scan data was reconstructed with two segment reconstruction algorithms and three segment reconstruction algorithms respectively. In control group, 30 patients whose heart beat were <65 bpm were treated with 350 ms/rot gantry rotation and half reconstruction. Image qualities were compared from the different gantry rotation, reconstruction algorithm and heart rate. Results: All of 1191 segments (1191/1708, 69.73%) were graded score 1 in two segment reconstruction algorithms; 1370 segments (1370/1708, 80.21%) were graded score 1 in three segment reconstruction algorithms; 348 segments (348/418, 83.25%) were graded score 1 in control group. There was significant difference between two segments reconstruction algorithms and control group (Z=4.60, P<0.001). There was no significant difference between three segment reconstruction algorithms and control group (Z=0.15, P=0.13). Different gantry rotations had no influence on image quality (χ2=0.98, P=0.61). Conclusion: According to the curve of temporal resolution-cardiac cycle, high image quality can be acquired in a range of heart rate of 65-122 bpm for CTCA through three segment reconstruction algorithms. Copyright © 2015 by the Press of Chinese Journal of Medical Imaging and Technology.


Li W.,Soochow University of China | Liang R.-R.,Soochow University of China | Zhou C.,The Central Hospital of Xuzhou | Wu M.-Y.,Soochow University of China | And 15 more authors.
Cancer Cell International | Year: 2015

Objective: Angiogenesis is a critical step of breast cancer metastasis. Oncogenic Ras promotes the remodeling of cancer microenviroment. Tumor-associated macrophages (TAMs) are a prominent inflammatory cell population emerging in the microenviroment and facilitating the angiogenesis and metastasis. In the present study, we tried to investigate the relationship between the expression of Ras and infiltration of TAM, both of which could further promote angiogenesis. Methods: Expressions of Ras, CD68 and CD34 were assessed by immunohistochemistry. The infiltration of macrophages was evaluated by counting the number of CD68+ cells. Vessel endothelial cells were defined as CD34+ cells. Angiogenesis vascularity was defined by microvessel density (MVD) assay through counting the number of vessels per field counted in the area of highest vascular density. The Kaplan-Meier survival analysis was used to estimate the overall survival (OS). Macrophages were derived from monocytes in the presence of macrophage colony-stimulating-factor (MCSF). Breast cancer cells were treated with macrophage-conditioned medium (MCM) and tested the expressions of K-, H- and N-Ras by using realtime-PCR. Results: Ras positive status was correlated with ER, PR and Her-2 positivity, larger tumour size and lymph node metastasis, as well as higher TNM stages. A higher number of CD68+ cells was correlated with larger tumour size, higher TNM stages and Her-2 positivity. Both Ras positivity and infiltration of CD68+ macrophages correlated with poor OS. The number of CD68+ cells was positively correlated with the expression of Ras. Treatment with MCM did not up-regulate but repressed the expression of Ras. Both up-regulation of Ras and infiltration of TAMs correlated with increased MVD. Conclusion: Expression of Ras and infiltration of TAM were positively correlated, and both participated in angiogenesis. Elevated Ras could be responsible for the infiltration of TAM. © Li et al.; licensee BioMed Central.


PubMed | The Central Hospital of Xuzhou and Soochow University of China
Type: Journal Article | Journal: Oncology letters | Year: 2017

MicroRNAs (miRNAs) are short, non-coding RNA molecules that act as regulators of gene expression. Circulating blood miRNAs have potential as cancer biomarkers. The main objective of the present study was to assess the effect of miRNA-23b (miR-23b) expression in plasma on the diagnosis and prognosis of colorectal cancer (CRC). Reverse transcription-quantitative polymerase chain reaction (PCR) was used to measure miR-23b expression levels, and methylation-specific PCR was used to test the promoter methylation status. Subsequently, the expression level of miR-23b in plasma samples was compared between CRC patients and healthy control individuals. The miR-23b expression levels were significantly lower in CRC cells and primary CRC tissues than in nonmalignant colorectal tissues (P<0.001). It was also shown that miR-23b expression is downregulated by promoter methylation and can be restored by demethylation agent treatment. miR-23b was significantly decreased in plasma samples from CRC patients compared with the healthy control individuals (P<0.001). The value of the area under the receiver operating characteristic curve was 0.842 (sensitivity, 84.38%; specificity, 77.08%; 95% confidence interval, 0.763-0.922). Low plasma miR-23b expression was significantly associated with clinical stage, tumor depth, distant metastasis and tumor recurrence. CRC patients with low miR-23b expression in plasma exhibited a shorter recurrence-free survival time and poorer overall survival rate. The present results suggested that the downregulation of miR-23b in the plasma has the potential to be a diagnostic and prognostic biomarker in CRC.


Li Z.P.,The Central Hospital of Xuzhou
Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology | Year: 2013

To present 4 cases of hemophilic pseudotumor and to investigate the treatment outcome. Four cases of hemophilic pseudotumor were reviewed. The patients were treated by internal medicine combined with surgery and followed up for two years. The feature and diagnosis of the disease were analyzed and the treatment outcome was evaluated. All of the 4 cases were misdiagnosed with a history of bleeding before operation. One patient was bleeding after biopsy without replacement therapy. One patient was presented with gingival bleeding and anaemia. The final diagnosis of hemophilia A in all the 4 cases was confirmed by the blood test (VIII deficiency). After infusion of factor VIII, operation was performed on all cases. There was no recurrence after two years of follow-up. It should be aware of the rarely encountered disease which is prone to be misdiagnosed. Under factor-deficient replacement therapy, surgical management is the most effective way in preventing from bleeding and avoiding progressive expanding of pseudotumor.


Zhou C.,The Central Hospital of Xuzhou | Bu X.,The Central Hospital of Xuzhou | Li X.,The Central Hospital of Xuzhou | Liu L.,The Central Hospital of Xuzhou | And 3 more authors.
Cell Biochemistry and Biophysics | Year: 2015

We report here a case of nasal natural killer/T-cell lymphoma with metastasization into the pancreas. A 43-year-old Chinese female patient presented with right nasal obstruction and purulent rhinorrhea that lasted for the past half year and worsened gradually despite antibiotic medical treatment. Physical examination revealed a mass in the right nasal cavity and an enlarged lymph node in the right submandibular region. A PET/CT scan and immunostaining of the resectate led to a diagnosis of nasal natural killer/T-cell lymphoma, clinical stage IIE, and the International Prognostic Index score of 1. The patient received radiotherapy followed by four cycles of the CHOP chemotherapy. A complete remission was achieved, and the patient was disease-free for 9 months. On a subsequent follow-up, abdominal ultrasound scan, enhanced abdominal CT scan, and ultrasound-guided fine-needle aspiration biopsy revealed pancreatic metastasis secondary to nasal lymphoma. Radiotherapy (40 Gy) to the whole pancreas was done, followed by two courses of the SMILE regime chemotherapy, leading to a complete remission. At the moment, the patient is undergoing subsequent chemotherapy. © 2015, Springer Science+Business Media New York.


An X.-L.,The Central Hospital of Xuzhou | Li C.-L.,The Central Hospital of Xuzhou
Cell Biochemistry and Biophysics | Year: 2014

This study aimed to identify risk factors for vascular cognitive impairment (VCI) in cerebral infarction patients. Associations between VCI and age, gender, blood pressure, lipid levels, glycosylated hemoglobin, atrial fibrillation, tobacco smoking, alcohol consumption, homocysteine (Hcy), and High-Sensitivity C-Reactive Protein (HS-CRP) were evaluated in patients with cerebral infarction (n = 300) using single factor analysis and multivariate logistic regression analysis. By single factor analysis, the age, glycosylated hemoglobin, atrial fibrillation, blood pressure, Hcy, HS-CRP, tobacco smoking, and alcohol consumption were significantly associated with VCI in these patients. By multivariate logistic regression analysis, the age, glycosylated hemoglobin, blood pressure, Hcy, and HS-CRP were revealed as independent risk factors. The age, glycosylated hemoglobin, blood pressure, Hcy, and HS-CRP can serve as predictive factors for VCI in patients with cerebral infarction. © 2014, Springer Science+Business Media New York.


PubMed | The Central Hospital of Xuzhou
Type: Case Reports | Journal: Cell biochemistry and biophysics | Year: 2016

We report here a case of nasal natural killer/T-cell lymphoma with metastasization into the pancreas. A 43-year-old Chinese female patient presented with right nasal obstruction and purulent rhinorrhea that lasted for the past half year and worsened gradually despite antibiotic medical treatment. Physical examination revealed a mass in the right nasal cavity and an enlarged lymph node in the right submandibular region. A PET/CT scan and immunostaining of the resectate led to a diagnosis of nasal natural killer/T-cell lymphoma, clinical stage IIE, and the International Prognostic Index score of 1. The patient received radiotherapy followed by four cycles of the CHOP chemotherapy. A complete remission was achieved, and the patient was disease-free for 9months. On a subsequent follow-up, abdominal ultrasound scan, enhanced abdominal CT scan, and ultrasound-guided fine-needle aspiration biopsy revealed pancreatic metastasis secondary to nasal lymphoma. Radiotherapy (40Gy) to the whole pancreas was done, followed by two courses of the SMILE regime chemotherapy, leading to a complete remission. At the moment, the patient is undergoing subsequent chemotherapy.


PubMed | The Central Hospital of Xuzhou
Type: Journal Article | Journal: Oncology letters | Year: 2017

The feasibility and clinical application of single-hole video-assisted thoracoscope in pulmonary peripheral tumors was examined. From March, 2011 to March, 2015, we retrospectively analyzed the clinical data obtained from 32 patients with pulmonary peripheral tumor that received single-hole thoracoscopic surgery. We completed the surgery via a 1.5-cm incision on the seventh or eighth rib in midaxillary line as the observation hole, and a 4.0-5.0-cm incision in the lateral margin of pectoralis major in the fourth or fifth rib in midaxillary line as the operation hole. All the patients had completed the tumor-reductive surgery under single-hole thoracoscope successfully. None required second operation hole or needed a transfer to thoracotomy. Operation time was 40-100 min with an average of 65.7815.87 min. Intraoperative blood loss was 20-100 ml, with an average of 47.1926.91 ml. Post-operative chest drainage time was 3-6 days, with an average of 4.220.87 days. Hospitalization time after operation was 5-7 days, with an average hospitalization time of 5.970.82 days. No patient received a second surgery for pulmonary leak or bleeding and no patient had any complication. All the cases recovered without any problem. In conclusion, for patients with pulmonary peripheral tumor, single-hole video-assisted thoracoscope could further reduce their surgical trauma. The operation was safe and feasible and worthy of wide application.

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