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Zhou J.,Xiamen University | Wu S.-G.,Xiamen University | Wang J.-J.,The Central Hospital of Xinxiang | Sun J.-Y.,Sun Yat Sen University | And 4 more authors.
Cancer Research and Treatment | Year: 2015

Purpose: The purpose of this study was to assess the value of ovarian ablation using goserelin in premenopausal patients with stage II/III hormone receptor-positive breast cancer without chemotherapy-induced amenorrhea (CIA). Materials and Methods: We retrospectively reviewed the data of breast patients treated between October 1999 and November 2007 without CIA. The Kaplan-Meier method was used for calculation of the survival rate. Log rank method and Cox regression analysis were used for univariate and multivariate prognostic analysis. Results: The median follow-up period was 61 months. Initially, 353 patients remained without CIA after chemotherapy and 98 among those who received goserelin and tamoxifen (TAM). In univariate analysis, goserelin improved locoregional recurrence-free survival (LRFS) (98.9% vs. 94.1%, p=0.041), distant metastasis-free survival (DMFS) (85.4% vs. 71.9%, p=0.006), disease-free survival (DFS) (85.4% vs. 71.6%, p=0.005), and overall survival (OS) (93.5% vs. 83.5%, p=0.010). In multivariate analysis, goserelin treatment was an independent factor influencing DMFS (hazard ratio [HR], 1.603; 95% confidence interval [CI], 1.228 to 2.092; p=0.001), DFS (HR, 1.606; 95% CI, 1.231 to 2.096; p=0.001), and OS (HR, 3.311; 95% CI, 1.416 to 7.742; p=0.006). In addition, treatment with goserelin resulted in significantly improved LRFS (p=0.039), DMFS (p=0.043), DFS (p=0.036), and OS (p=0.010) in patients aged < 40 years. In patients aged ≥ 40 years, goserelin only improved DMFS (p=0.028) and DFS (p=0.027). Conclusion Ovarian ablation with goserelin plus TAM resulted in significantly improved therapeutic efficacy in premenopausal patients with stage II/III hormone receptor-positive breast cancer without CIA. © 2015 by the Korean Cancer Association. Source


Wei W.,The Central Hospital of Xinxiang | Li R.-X.,The Central Hospital of Xinxiang | Shang X.-J.,The Central Hospital of Xinxiang | Peng X.,The Central Hospital of Xinxiang
World Chinese Journal of Digestology | Year: 2015

AIM: To evaluate the efficacy of an improved surgical procedure for treatment of puborectalis syndrome. METHODS: This prospective randomized study included 54 patients suffering from puborectalis syndrome. They were randomized into two groups: a control group which included 27 patients who underwent partial division of puborectalis and an observation group which included 27 patients who received an improved surgical procedure (partial division of puborectalis plus rectal serosal gomphosis and lateral internal sphincterotomy). The total effective rate and recurrence rate were compared for the two groups. RESULTS: After one year and a half, the total effective rate in the observation group was 92.6%, significantly higher than that in the control group (59.3%, P < 0.05). The recurrence rate in theobservation group was 3.8%, significantly lower than that in control group (36%, P < 0.05). CONCLUSION: The improved surgery has low recurrence rate and high safety. © 2015 Baishideng Publishing Group Inc. All rights reserved. Source


Wei W.,The Central Hospital of Xinxiang | Li B.-Q.,The Central Hospital of Xinxiang | Li R.-X.,The Central Hospital of Xinxiang | Peng X.,The Central Hospital of Xinxiang
World Chinese Journal of Digestology | Year: 2015

AIM: To evaluate and compare the clinical outcomes of transabdominal and transperineal surgical procedures for patients with complete rectal prolapse. METHODS: A retrospective study was performed of patients with complete rectal prolapse who received surgical treatment at the Central Hospital of Xinxiang between March 1995 and May 2014. Patients were classified according to the type of operation: transabdominal procedure (n = 64) and transperineal procedure (n = 40). Clinical effects were compared for the two groups. RESULTS: There were more young patients and males in the transabdominal group than in the transperineal group. Compared with the transperineal group, the transabdominal group had longer operating time (165 min ± 67 min vs 70 min ± 38 min, P < 0.001), longer hospital stay (10 d ± 4 d vs 7 d ± 2 d, P < 0.001), but a lower overall recurrence rate (6.3% vs 15.0%, P < 0.05). The overall rate of complications was similar between the two groups (10.9% vs 6.8%, P > 0.05). The patients in the transabdominal group complained mor e f r equent ly of constipation than of incontinence, conversely, in the transperineal group of incontinence than of constipation. CONCLUSION: The two approaches for treating complete rectal prolapse did not differ with regard to postoperative morbidity, but recurrence occurs frequently among patients in the transperineal group. Surgeons should carefully assess the condition of patients before operation and select the appropriate surgical approach for treating complete rectal prolapse. © 2015 Baishideng Publishing Group Inc. All rights reserved. Source


Wei W.,The Central Hospital of Xinxiang | Shang X.-J.,The Central Hospital of Xinxiang | Lv B.-Z.,The Central Hospital of Xinxiang
World Chinese Journal of Digestology | Year: 2011

AIM: To identify differentially expressed serum proteins between preoperative patients with hereditary nonpolyposis colorectal cancer (HNPCC) and those with sporadic colorectal cancer to find potential markers for the diagnosis of HNPCC. METHODS: The composition of serum proteins was detected by surface-enhanced laser desorption/ ionization time-of-flight mass spectrometry (SELDI-TOF-MS) and protein chip assay in 20 preoperative HNPCC patients and 25 patients with sporadic colorectal cancer. Discriminatory serum protein profiles were analyzed with the Biomarker Wizard software and Biomarker Pattern software. RESULTS: Two proteins (m/z 7 516.68 Da and 4 827.07 Da) were chosen to create a decision classification tree model which could discriminate the two groups of patients. In the test mode, the accuracy, sensitivity, specificity, and positive predictive value of the model for prediction of HNPCC was 86.7%, 72.3%, 95.1% and 92.5%, respectively, while the corresponding values for blinded validation were 75.6%, 100%, 69.8% and 99.2%, respectively. CONCLUSION: The classification tree model constructed with two differentially expressed proteins identified by SELDI-TOF-MS between HNPCC patients and patients with sporadic colorectal cancer possesses high sensitivity and specificity in the prediction of HNPCC. Source


Wei W.,The Central Hospital of Xinxiang | Li R.-X.,The Central Hospital of Xinxiang | Peng X.,The Central Hospital of Xinxiang | Lv J.-D.,The Central Hospital of Xinxiang
World Chinese Journal of Digestology | Year: 2015

Aim: To compare the results of transanal vs transvaginal repair of symptomatic rectocele and to determine the long-term clinical outcomes according to the change in the depth of the rectocele after the procedure. Methods: This study included 50 women suffering from rectocele. They were randomized into two groups: 25 women (group A) receiving a transanal repair and 25 (group B) receiving a transvaginal repair. The relevant postoperative indexes were compared for the two groups. Results: At 12 mo after surgery, 17 women in each group (group A/B, 77%/74%) reported improvement of their symptoms. However, only 11 and 13 women of groups A and B (group A/B, 55%/59%), respectively, maintained their improvement during the median follow-up of 50 mo. Better results were reported in patients with a greater change in the depth of their rectocele (≥4 cm) after the procedure (P = 0.001). Conclusion: In both procedures, clinical outcomes might become progressively worse as the length of the follow-up is increased. A preoperative larger rectocele might have a better postoperative outcome. © 2015 Baishideng Publishing Group Inc. All rights reserved. Source

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