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Dai D.,The Center Hospital of Cangzhou | Wang Z.,The Center Hospital of Cangzhou | Zhao J.,The Center Hospital of Cangzhou | Liang Y.,The Center Hospital of Cangzhou | Liu Y.,The Center Hospital of Cangzhou
Zhonghua Shiyan Yanke Zazhi/Chinese Journal of Experimental Ophthalmology | Year: 2014

Background: Clinical study showed that FP-7/FP-8 Ahmed glaucoma valve implantation is effective and safe for the adult refractory glaucoma. However, it is well-known that childhood glaucomatous eyes have different pathogenesis and protean clinical manifestations. So the efficacy of FP-7/FP-8 Ahmed glaucoma valve implantation in child deserves some attention. Objective: This study was to retrospectively evaluate the efficacy and safety of FP-7/FP-8 Ahmed glaucoma valve implantation for refractory glaucoma in children. Methods: The clinical data of 30 eyes of 26 children with refractory glaucoma who undergone FP-7/FP-8 Ahmed glaucoma valve implantation in the Center Hospital of Cangzhou from October 2008 to April 2011 were retrospectively analyzed. The age of patients was 4 months to 16.5 years. The patients included ocular hypertension after trabculectomy/goniotomy for cogenital glaucoma, later stage of cogenital glaucoma, aphakic or pseudophakic glaucoma, traumatic glaucoma and Sturge-Weber syndrome. The follow-up ranged from 1 week to 24 months to obverse the changes of intraocular pressure (IOP) postoperative complications and cumulative success rate. Results: The mean IOP was significantly different among various time points (F=58.929, P<0.05). The IOP was (36.93±10.56) mmHg in preoperation and (13.13±3.34), (14.13±3.15), (15.93±4.76), (17.96±5.37), (19.74±5.43) mmHg 1 week, 1 month, 6 months, 12 months, 24 months following surgery, showing significant reduce after operation. Compared with preoperative IOP, the IOP of 1 week, 1 month, 6, 12, 24 months after AGI was significant decreased, with significant differences between them (t=11.641, 11.458, 10.688, 7.988, 8.018, all at P<0.05). The total cumulative success rate after Ahmed glaucoma valve implant was 100%, 96.67%, 93.21%, 85.76% and 71.46% 1 week, 1 month, 6 months, 12 months, 24 months after surgery. The postoperative complications occurred in 8 eyes, including shallow anterior chamber, drainage tube obstruction, hyphema of anterior chamber and valve exposure, and these were cured by medicine and surgery. No serious complication appeared in all patients after operation. Conclusions: FP-7/FP-8 Ahmed glaucoma valve implantation is an effective and safe method for the treatment of refractory glaucoma, and it can be considered as one of the first choices for management of refractory glaucoma in childhood. Copyright © 2014 by the Chinese Medical Association. Source


Zhang W.,The Center Hospital of Cangzhou | Bai X.,The Center Hospital of Cangzhou | Ge H.,The Center Hospital of Cangzhou | Cui H.,The Center Hospital of Cangzhou | And 2 more authors.
International Journal of Clinical and Experimental Medicine | Year: 2014

Although many epidemiologic studies have investigated obesity and thyroid cancer risk, definite conclusions cannot be drawn. To clarify the effects of obesity on the risk of thyroid cancer, a meta-analysis was performed. Related studies were identified from PubMed, Springer Link, Ovid, Chinese Wanfang Data Knowledge Service Platform, Chinese National Knowledge Infrastructure (CNKI), and Chinese Biology Medicine (CBM) till 16 Aug 2014. Pooled RRs and 95% CIs were used to assess the strength of the associations. A total of 16 studies including 12616154 subjects were involved in this meta-analysis. A significantly elevated thyroid cancer risk was found in overall analysis (RR = 1.29, 95% CI 1.20-1.37, P < 0.00001). In the gender subgroup analyses, a statistically significant association was found in male patients (RR = 1.35, 95% CI 1.16-1.58, P = 0.0001) and in female patients (RR = 1.29, 95% CI 1.19-1.40, P < 0.00001). When we limited the meta-analysis to studies that controlled for age (RR = 1.34, 95% CI 1.24-1.44, P < 0.00001), smoke (RR = 1.36, 95% CI 1.22-1.52, P < 0.00001), alcohol use (RR = 1.40, 95% CI 1.15-1.71, P = 0.0009), and history of benign thyroid disease (RR = 1.51, 95% CI 1.24-1.83, P < 0.0001), a significant association between obesity and thyroid cancer risk remained. This meta-analysis provides the evidence that obesity may contribute to the thyroid cancer development. © 2014, E-Century Publishing Corporation. All Rights Reserved. Source


Han G.,The Center Hospital of Cangzhou | Wei Z.,The Center Hospital of Cangzhou | Lu Z.,The Center Hospital of Cangzhou | Cui H.,The Center Hospital of Cangzhou | And 3 more authors.
International Journal of Clinical and Experimental Medicine | Year: 2014

The association between MMP1-1607 1G>2G polymorphism and cancer risk has been reported, but results remained controversial and ambiguous. To assess the association between MMP1-1607 1G>2G polymorphism and cancer risk, a meta-analysis was performed. Based on comprehensive searches of the PubMed, Elsevier Science Direct, Excerpta Medica Database (Embase), and Chinese Biomedical Literature Database (CBM), we identified outcome data from all articles estimating the association between MMP1-1607 1G>2G polymorphism and cancer risk. The pooled odds ratio (OR) with 95% confidence intervals (CIs) were calculated. Thirty-eight studies involving 10178 cases and 9528 controls were included. Overall, significant association between MMP1-1607 1G>2G polymorphism and cancer susceptibility was observed for additive model (OR = 1.21, 95% CI 1.09-1.35), for codominant model (OR = 1.34, 95% CI 1.10-1.63), for dominant model (OR = 1.17, 95% CI 1.01-1.34), for recessive model (OR = 1.31, 95% CI 1.14-1.52). In the subgroup analysis by ethnicity, the significant association was found among Asians but not among Caucasians. In the subgroup analysis by site of cancer, significant associations were found among lung cancer, colorectal cancer, head and neck cancer and bladder cancer. This meta-analysis demonstrated that the MMP1-1607 1G>2G polymorphism was significantly associated with cancer risk. © 2014, International Journal of Clinical and Experimental Medicine. All rights reserved. Source

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