The Center for Process Innovation

Redcar, United Kingdom

The Center for Process Innovation

Redcar, United Kingdom
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Alonso S.,The Center for Process Innovation | Rendueles M.,University of Oviedo | Diaz M.,University of Oviedo
Process Biochemistry | Year: 2017

Triggering the switch from growth to lactobionic acid formation in Pseudomonas taetrolens is crucial to attain a high-yield bio-production system. This study elucidates how the growth-coupled and uncoupled lactobionic acid formation ratio can be modulated through the application of temperature-control strategies. Whereas the combination of high initial cell densities with a temperature value of 30. °C stimulated the onset of the lactobionic acid production phase from early cultivation times, temperature-stat conditions below 28. °C and above 30. °C led to a growth-coupled lactobionic acid formation with reduced cell growth. Further implementation of a temperature-control bioprocessing strategy at 28. °C with a pH-shift cultivation at 6.5 resulted in higher lactobionic acid yields (98%), volumetric productivity (2.04. g/L. h), and specific productivity rates (1.73. g/g. h) within only 24. h. Controlling the culture temperature at 28. °C via either temperature-stat or -shift bioprocessing strategies led to an overproduction of lactobionic acid, overcoming the low-yield mixed-growth-associated production patterns found at temperatures different than 28. °C. This novel temperature-driven approach provides a step forward in the bio-based production of lactobionic acid at high specific production rates and yields by uncoupling completely the production phase from the cell growth. © 2017 Elsevier Ltd.

Jun S.Y.,University of Canterbury | Sanz-Izquierdo B.,University of Canterbury | Parker E.A.,University of Canterbury | Bird D.,The Center for Process Innovation | McClelland A.,The Center for Process Innovation
IEEE Transactions on Components, Packaging and Manufacturing Technology | Year: 2017

The use of additive manufacturing (AM) techniques for the fabrication of 3-D fractal monopole antennas is presented. The 3-D printing (3-D P) of 3-D designs based on the Sierpinski fractal concept is studied, and the performance discussed. The AM allows the fabrication of the complex features of these antennas. The specific structures, on the other hand, provide a reduction of the material used in AM compared with the equivalent nonfractal designs, in which two cases can be described by over 75%. This is the first time that 3-D fractals have been studied in terms of volume reduction and their potential benefits to AM of antennas. The first investigated antenna derives from the Sierspinki tetrahedron fractal shape. From this initial design, two new structures have been developed: the dual Sierpinksi fractal and the dual inverse Sierpinski fractal. The new designs offer improved matching and radiation pattern. All the antennas operate at 2.4 GHz used in Bluetooth and wireless LAN band. Furthermore, the final inverse fractal shape is able to cover both the 2.4- and 5.5-GHz WLAN frequencies with a reflection coefficient (S₁₁) better than -10 dB, together with coverage at bands around 8 GHz. This ratio of resonant frequencies is achieved after a series of described design stages. The radiation patterns of the antennas are monopole-like at both bands. The AM technique employed is metal powder embinder printing where a binding material is jetted on a powder bed containing metal particles. Metal 3-D P is ideal for maintaining the mechanical strength of the structures. The envisaged applications are in the defense and aerospace sectors where high-value, lightweight, and mechanically robust antennas can be integrated with other 3-D printed parts. Transient simulations based on the finite integration technique compare well with measurements. CCBY

Abbott M.S.R.,Northumbria University | Abbott M.S.R.,The Center for Process Innovation | Brain C.M.,Northumbria University | Harvey A.P.,Northumbria University | And 2 more authors.
Chemical Engineering Science | Year: 2015

Chlamydomonas reinhardtii (CCAP 11/32C) cells were grown in liquid culture under photoautotrophic conditions using a photobioreactor (PBR) based on oscillatory baffled reactor (OBR) technology. A flotation effect was observed when using a porous gas sparger which resulted in accumulation of microalgae at the top of the column. Linear growth was achieved with a different sparger, designed to produce larger, faster rising gas bubbles. Changes in the mixing intensity had no effect on the maximum growth rate of 0.130OD750/day (±0.010) achieved which was 95% higher than that achieved in T-flasks of 0.067OD750/day (±0.011) under comparable conditions. The increase in growth rate achieved in the OBR was probably a result of increased gas transfer, and exponential growth was not achieved probably due to the relatively low light intensity used of 78μmol/m2s (±20). The results demonstrate the feasibility of OBR technology for use as PBRs with the potential for the duel culture and harvest of microalgal biomass through manipulation of the bubble diameter. This could greatly improve bioprocess economics for microalgae culture. © 2015 Elsevier Ltd.

Abbott M.S.R.,Northumbria University | Abbott M.S.R.,The Center for Process Innovation | Valente Perez G.,The Center for Process Innovation | Harvey A.P.,Northumbria University | Theodorou M.K.,Harper Adams University College
Chemical Engineering Research and Design | Year: 2014

Enzymatic saccharification of pure α-cellulose was conducted in oscillatory baffled (OBR) and stirred tank (STR) reactors over a range of mixing intensities requiring power densities (P/V) from 0 to 250Watts per cubic metre (W/m3). Both reactor designs produced similar saccharification conversion rates at zero mixing. Conversion increased with increasing mixing intensity. The maximum conversion rate occurred at an oscillatory Reynolds number (Reo) of 600 in the OBR and at an impeller speed of between 185 and 350rpm in the STR. The OBR was able to achieve a maximum conversion rate at a much lower power density (2.36W/m3) than the STR (37.2-250W/m3). The OBR demonstrated a 94-99% decrease in the required power density to achieve maximum conversion rates and showed a 12% increase in glucose production after 24h at 2.36W/m3. © 2014 The Institution of Chemical Engineers.

Abbott M.S.R.,Northumbria University | Abbott M.S.R.,The Center for Process Innovation | Harvey A.P.,Northumbria University | Valente Perez G.,The Center for Process Innovation | Theodorou M.K.,The Center for Process Innovation
Interface Focus | Year: 2013

The development of efficient and commercially viable bioprocesses is essential for reducing the need for fossil-derived products. Increasingly, pharmaceuticals, fuel, health products and precursor compounds for plastics are being synthesized using bioprocessing routes as opposed to more traditional chemical technologies. Production vessels or reactors are required for synthesis of crude product before downstream processing for extraction and purification. Reactors are operated either in discrete batches or, preferably, continuously in order to reduce waste, cost and energy. This review describes the oscillatory baffled reactor (OBR), which, generally, has a niche application in performing 'long' processes in plug flow conditions, and so should be suitable for various bioprocesses. We report findings to suggest that OBRs could increase reaction rates for specific bioprocesses owing to low shear, good global mixing and enhanced mass transfer compared with conventional reactors. By maintaining geometrical and dynamic conditions, the technology has been proved to be easily scaled up and operated continuously, allowing laboratory-scale results to be easily transferred to industrial-sized processes. This is the first comprehensive review of bioprocessing using OBRs. The barriers facing industrial adoption of the technology are discussed alongside some suggested strategies to overcome these barriers. OBR technology could prove to be a major aid in the development of commercially viable and sustainable bioprocesses, essential for moving towards a greener future. © 2012 The Author(s) Published by the Royal Society. All rights reserved.

Agency: GTR | Branch: Innovate UK | Program: | Phase: Collaborative Research & Development | Award Amount: 337.48K | Year: 2015

The project partners will integrate printed electronics (PE) and conventional (CE) solid state electronics in order to improve functionality, reduce cost and increase scalability of a photonics based medical device. New methods will be employed in order to produce luminaires, printed sensors and PE/PE or PE/CE interconnects. These will be combined with conventional electronics such as memory and processors to make the device smart and therefore ensure patient compliance with the treatment regime.

Wall D.M.,The Center for Process Innovation | Wu-Haan W.,Michigan State University | Safferman S.I.,Michigan State University
Biomass and Bioenergy | Year: 2012

Solid residuals generated from dewatering food processing wastewater contain organic carbon that can potentially be reclaimed for energy through anaerobic digestion. This results in the diversion of waste from a landfill and uses it for a beneficial purpose. Dewatering the waste concentrates the carbon, reducing transportation costs to a farm digester where it can be blended with manure to increase biogas yield. Polymers are often used in the dewatering of the food waste but little is known regarding their impact on biogas production. Four 2 dm3 working volume, semi-continuous reactors, were used at a mesophilic temperature and a solids retention time (SRT) of 15 days. Reactors were fed daily with a blended feedstock containing a food processing sludge waste (FPSW)/manure ratio of 2.2:1 (by weight) as this produced the optimized carbon to nitrogen ratio. Results demonstrated that reconstitution of dewatered FPSW with dairy manure produced approximately 2 times more methane than animal manure alone for the same volume. However, only approximately 30% of volatile solids (VS) were consumed indicating energy potential still remained. Further, the efficiency of the conversion of VS to methane for the blended FPSW/manure was substantially less than for manure only. However, the overall result is an increase in energy production for a given tank volume, which can decrease life cycle costs. Because all FPSW is unique and the determination of dewatering additives is customized based on laboratory testing and field adjustment, generalizations are difficult and specific testing is required. © 2012 Elsevier Ltd.

Agency: GTR | Branch: Innovate UK | Program: | Phase: Collaborative Research & Development | Award Amount: 265.73K | Year: 2013

New reactor technologies are set to allow products that have traditionally been made in batches to be produced in a continuous manner. These reactors have the potential to transform manufacturing sectors by reducing energy, waste and the cost of manufacture and distribution. The technology will allow companies to use a single reactor for a number of products rather than investing in a number of task specific batch reactors. Therefore this project aims to develop an adaptive Dial a Product control system to deliver the precise control required for these unique high value low volume manufacturing systems. Bringing together control design and analytical techniques to complement these reactors will enable the reactors to reach optimum performance quickly and efficiently as the manufacturer switches between products.

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