Time filter

Source Type

PubMed | From The Center for Hypertension of the Peoples Hospital of Xinjiang Uygur Autonomous Region
Type: Journal Article | Journal: Medicine | Year: 2015

Increasing evidence showed a link between arterial elasticity and stiffness and pulse pressure (PP), in which plasma aldosterone may play a role. The observational study aimed to explore the potential relations between plasma aldosterone concentration (PAC) and PP in patients with hypertension. We evaluated the relation between PP and PAC in supine, seated, and upright positions in 195 patients with primary hypertension who underwent postural stimulation test. They were divided into 3 groups by tertiles of PP: PP44 mm Hg (n=70), 44 mm Hg12 ng/dL showed greater PP than those with PAC12 ng/dL. Third, weak associations between PP and upright (r=0.288, P<0.001), seated (r=0.265, P<0.001), and supine postures (r=0.191, P=0.008) were detected by simple correlation analysis. After corrected serum K, age, and sex, the partial correlation coefficients did not change greatly. Fourth, the logistic regression model was constructed with PP40 mm Hg or PP<40 mm Hg as the dependent variable; the serum K[OR=0.043, 95% CI: 1.09(1.00-1.12)] and PAC [OR=0.025, 95%CI: 0.35(0.13-0.88)] were included as significant contributing factors. The results showed that higher PAC was weakly, but significantly, correlated to greater PP regardless of different postures, suggesting that higher PAC may be a risk factor of reduced arterial elasticity in patients with hypertension.

Loading From The Center for Hypertension of the Peoples Hospital of Xinjiang Uygur Autonomous Region collaborators
Loading From The Center for Hypertension of the Peoples Hospital of Xinjiang Uygur Autonomous Region collaborators