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Pierse J.E.,The Brooklyn Hospital Center | Stern A.,The Brooklyn Hospital Center
Oral and Maxillofacial Surgery Clinics of North America | Year: 2012

To thoroughly understand the biology of any lesion and render the appropriate management, clear and accurate definitions are paramount. For benign cysts and tumors of the oral maxillofacial region, an accurate depiction of these lesions needs to be elucidated to provide both the treating surgeon and the patient with a clear understanding of the course of treatment and the outcome. © 2012 Elsevier Inc.


Tagliareni J.M.,The Brooklyn Hospital Center | Clarkson E.I.,The Brooklyn Hospital Center
Oral and Maxillofacial Surgery Clinics of North America | Year: 2012

Oral and maxillofacial surgeons are occasionally called on to diagnose, treat, and rule out peritonsillar abscesses. In this article, the anatomy of the peritonsillar area, its contents, surgical approaches, and possible complications are discussed. © 2012 Elsevier Inc.


Chatzicharalampous C.,The Brooklyn Hospital Center | Bray M.A.,The Brooklyn Hospital Center
Journal of Reproductive Medicine | Year: 2016

BACKGROUND: Isolated hematotrachelos is an extremely rare condition. More commonly it is associated with hematometra and/or hematocolpos. It may devel op secondary to congenital anomalies of the reproductive tract or may be an acquired condition following cervical surgery or manipulation. No case has been reported following abdominal myomectomy. CASE: A 40-year-old, nulligravid woman was diagnosed with isolated hemato trachelos when she presented with severe abdominal pain following ovulation induction with clomiphene citrate. After the diagnosis was obtained, she recounted 2 similar presentations occurring months earlier. Both episodes had been attributed to gastroenteritis, but each had resolved with “explosive” onset of menses. All 3 episodes plus 1 later recurrence happened within a 36-month period following an abdominal myomectomy. CONCLUSION: Acquired hematotrachelos is a rare condition, and the diagnosis is often missed. To our knowledge, this is the first reported case of isolated, recurrent hematotrachelos following the use of a uterine manipulator cannula in association with an abdominal myomectomy. © Journal of Reproductive Medicine®, Inc.


The hypothesis is formulated and presented that resveratrol and vitamin D have important mutual processes, interactions and induced effects that if not taken into account could seriously jeopardize the interpretation of their current and future preclinical, epidemiological and clinical studies. In support of this hypothesis, evidence is presented that resveratrol and vitamin D mutually share some of the same biochemical processes and mechanisms as well as the fact that they can each affect some of the same diseases and maladies. © 2011 Elsevier Ltd.


Hayes D.P.,The Brooklyn Hospital Center
Medical Hypotheses | Year: 2010

There is historic evidence that influenza pandemics are associated with solar activity cycles (the Schwabe-cycle of about 11-years periodicity). The hypothesis is presented and developed that influenza pandemics are associated with solar control of vitamin D levels in humans which waxes and wanes in concert with solar cycle dependent ultraviolet radiation. It is proposed that this solar cycle dependence arises both directly from cyclic control of the amount of ultraviolet radiation as well as indirectly through cyclic control of atmospheric circulation and dynamics. © 2009 Elsevier Ltd.


Dym H.,The Brooklyn Hospital | Wolf J.C.,The Brooklyn Hospital Center
Oral and Maxillofacial Surgery Clinics of North America | Year: 2012

The practicing oral and maxillofacial surgeon treating patients with oroantral communication (OAC)/oroantral fistulas should be familiar and competent with the various treatment options available. Multiple techniques are available from purely soft tissue flaps, which have proved to be successful over time, to a combination of hard tissue grafts (autologous, alloplastic, or allograft), which can prove to be useful with the increased demand for implant restorations. Although different procedures have proved to be successful, all are premised on the treatment of any underlying sinusitis, which is associated with a higher risk of recurrent OAC. © 2012 Elsevier Inc.


Hayes D.P.,The Brooklyn Hospital Center
Dose-Response | Year: 2010

Nutritional hormesis has the potential to serve as a pro-healthy aging intervention by reducing the susceptibility of the elderly to various chronic degenerative diseases and thereby extending human healthspan. Supportive evidence for nutritional hormesis arising from essential nutrients (vitamins and minerals), dietary pesticides (natural and synthetic), dioxin and other herbicides, and acrylamide will be reviewed and discussed. © 2010 University of Massachusetts.


Hayes D.P.,The Brooklyn Hospital Center
Medical Hypotheses | Year: 2010

A whole host of epidemiological studies have reported lower cancer rates and mortality in high-altitude regions. These studies are reviewed and discussed in detail. Evidence for the salutary role of vitamin D in protecting against cancer and other maladies will also be reviewed and discussed. The dependence of vitamin D production on sunlight and its enhancement with altitude will be demonstrated. The hypothesis is advanced and developed that the lower cancer rates observed at high altitudes arise from enhanced sunlight-induced vitamin D production levels. Protective vitamin D mechanisms which support this hypothesis as well as other supportive medical evidence are also presented. © 2010 Elsevier Ltd.


Tun N.M.,The Brooklyn Hospital Center | Villani G.,Ralph Lauren Center for Cancer Care and Prevention | Ong K.,The Brooklyn Hospital Center | Yoe L.,The Brooklyn Hospital Center | Bo Z.M.,Springfield Regional Cancer Center
Clinical Genetics | Year: 2014

Testing for BRCA1 mutation has important clinical implications such as identifying risk of second primary cancers and risk of cancer in the family. This study seeks to quantify the risk of having BRCA1 mutation in female breast cancer patients with triple-negative phenotype compared with those with other phenotypes. We undertook a search of MEDLINE and EMBASE databases for relevant studies through 10 May 2013. Outcomes were calculated and reported as risk ratio and risk difference. 12 studies comprising 2533 breast cancer patients were included in the analysis. It was found that almost all eligible studies were performed on high-risk population with breast cancer. By analyzing the incidence rates of BRCA1 mutation in patients with triple-negative breast cancer (TNBC) and non-TNBC, our meta-analysis provides a relative risk of 5.65 [95% confidence interval (CI), 4.15-7.69] and risk difference of 0.22 (95% CI, 0.15-0.29). This implies that, in selected population with high-risk features, women with TNBC are approximately five and a half times more likely to have BRCA1 mutation compared with non-TNBC phenotype, and approximately two in nine women with TNBC harbor BRCA1 mutation. Triple-negative phenotype significantly increases the risk of having BRCA1 mutation in high-risk breast cancer patients compared with non-TNBC. © 2013 John Wiley & Sons A/S.


Olaywi M.,The Brooklyn Hospital Center | Bhatia T.,The Brooklyn Hospital Center | Anand S.,The Brooklyn Hospital Center | Singhal S.,The Brooklyn Hospital Center | Singhal S.,Columbia University
Hepatobiliary and Pancreatic Diseases International | Year: 2013

Background: Non-alcoholic fatty liver disease (NAFLD) encompasses a spectrum that ranges from simple steatosis to non-alcoholic steatohepatitis (NASH) and to cirrhosis. The recommended treatment for this disease includes measures that target obesity and insulin resistance. The present review summarizes the role of newer anti-diabetic agents in treatment of NAFLD. DATA SOURCES: PubMed, MEDLINE and Ovid databases were searched to identify human studies between January 1990 and January 2013 using specified key words. Original studies that enrolled patients with a diagnosis of NAFLD or NASH and involved use of newer classes of anti-diabetic agents for a duration of at least 3 months were included. Results: Out of the screened articles, four met eligibility criteria and were included in our review. The classes of newer anti-diabetic medications described were dipeptidyl peptidase IV inhibitors and glucagon-like peptide-1 analogues. Conclusions: Liraglutide and Exenatide showed improvement in transaminases as well as histology in patients with NASH. Sitagliptin showed improvement in transaminases but limited studies are there to access its effect on histology. Further studies are needed to support use of newer anti-diabetic medications in patients with NAFLD. © 2013, Hepatobiliary Pancreat Dis Int. All rights reserved.

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