Merenlender-Wagner A.,The Adams Super Center for Brain Studies |
Pikman R.,The Adams Super Center for Brain Studies |
Giladi E.,The Adams Super Center for Brain Studies |
Andrieux A.,Institute National Of La Sante |
And 2 more authors.
Peptides | Year: 2010
NAP (generic name, davunetide) is an active fragment of activity-dependent neuroprotective protein (ADNP). ADNP-/- embryos exhibit CNS dysgenesis and die in utero. ADNP+/- mice survive but demonstrate cognitive dysfunction coupled with microtubule pathology. NAP treatment ameliorates, in part, ADNP-associated dysfunctions. The microtubule, stable tubule-only polypeptide (STOP) knockout mice were shown to provide a reliable model for schizophrenia. Here, STOP-/- as well as STOP+/- showed schizophrenia-like symptoms (hyperactivity) that were ameliorated by chronic treatment with the antipsychotic drug, clozapine. Daily intranasal NAP treatment significantly decreased hyperactivity in the STOP+/- mice and protected visual memory. © 2010 Elsevier Inc. All rights reserved.