Lu L.,The 81 Hospital of Chinese PLA |
Wang X.,The 81 Hospital of Chinese PLA |
Zhang B.,The 81 Hospital of Chinese PLA |
Zhang D.-h.,The 81 Hospital of Chinese PLA |
Gu J.-y.,The Drum Tower Hospital of Nanjing
Chinese Journal of Tissue Engineering Research | Year: 2012
BACKGROUND: Recurrent hepato celluar carcinoma is very common after liver transplantation. There are no effective therapies for recurrent hepatocelluar carcinoma due to the rapid progress of tumor. OBJECTIVE: To observe the effects of sorafenib plus transcatheter arterial chemoembolization (TACE) and adjuvant chemotherapy in patients with recurrent hepatocelluar carcinoma after liver transplantation. METHODS: The clinical data of 24 patients with recurrent hepatocelluar carcinoma after liver transplantation were analyzed. Sixteen patients were only treated with TACE and adjuvant chemotherapy (control group); eight patients were treated with sorafenib plus TACE and adjuvant chemotherapy (combined group). The survival rates of 6 months and 1 year as well as tumor-free survival time were compared between two groups by Log-rank test. RESULTS AND CONCLUSION: The patients in the control group all died within 95 days of tumor-free survival time, whereas 100 days in the combined group, and there was no significant difference between two groups (P=0.280 5). During the follow-up, 16 patients in the control group were dead within 211 days of median survival time; the 6-month and 1-year overall survival rates of control group were 69% and 25%, respectively. Two patients were dead in the combined group within 1 100 days of the median survival time, the 6-month and 1-year overall survival rates were both 100%. There was significant difference in 6-month and 1-year overall survival rates between two groups (P < 0.000 1). Sorafenib plus TACE and adjuvant chemotherapy may prolong the survival of patients with recurrent hepatocelluar carcinoma after liver transplantation.
Fan Q.-h.,The 81 Hospital of Chinese PLA |
Chen Q.,The 81 Hospital of Chinese PLA |
Hong J.,The 81 Hospital of Chinese PLA |
Zhang Z.-q.,The 81 Hospital of Chinese PLA |
Yang Y.-q.,The 81 Hospital of Chinese PLA
Journal of Clinical Rehabilitative Tissue Engineering Research | Year: 2011
BACKGROUND: Following trauma caused by seawater, cells often exhibit special pathological changes because of the special physico-chemical properties of seawater. OBJECTIVE: To observe corneal histopathological changes and interleukin-6 level in aqueous humor of a rabbit model of penetrating corneal trauma combined with seawater immersion. METHODS: The rabbit eye models of penetrating corneal trauma caused by firecrackers were established in 16 adult healthy grey rabbits. A 3-mm whole-layer incision was made in the cornea. The right eyes served as experimental sides and the left eyes served as controls. Seawater was injected into the aqueous humor of the right eyes via the corneal incision. The eye surface was flushed with seawater for 30 minutes. Physiological saline was used for the left eyes. RESULTS AND CONCLUSION: Optical microscopy results showed that at 1, 2, 3 days after model establishment, corneal cells on the experimental side exhibited severe necrosis and abscission, obvious swelling of substantia propria layer complicated by cellular infiltration. At 1 and 2 days after model establishment, the pathological changes on the control side were the same as the experimental side, but they were mild, but at 3 and 5 days, they were obviously alleviated. At 1, 2, 3 days after model establishment, interleukin-6 level in aqueous humor was significantly higher on the experimental side than on the control side (P < 0.05). These findings suggest that the degree of injury on the experimental side was more severe than that on the control side, indicating that seawater may be an important causative factor of corneal injury.