Moshiri F.,The 5th hospital of Paris University |
Stanciulescu M.,The 5th hospital of Paris University |
Serane J.,The 5th hospital of Paris University |
el Koumiti N.,The 5th hospital of Paris University |
Lefevre E.,The 5th hospital of Paris University
Advances in Environmental Biology | Year: 2014
Recently, many studies have shown that gene polymorphism is related to osteoporosis. However, no studies have linked the association between IL11 gene polymorphism and bone mass in AIS. Methods: This study examined the association between bone mass and IL11 gene polymorphism in 198 girls with AIS between 07, 2011 till 08.2012 in the 5th hospital of Paris university. The polymorphisms of IL11-597 G→A, IL11-572 G→C and IL11-174 G→A and the bone mineral density in the lumbar spine and femoral neck were analyzed and compared with their levels in healthy controls. The mean bone mineral density at both sites in patients with AIS was decreased compared with controls (p = 0.0012 and p = 0.0013, respectively). Comparison of genotype frequencies between AIS and healthy controls revealed a statistically significant difference in IL11-572 G→C polymorphism (p = 0.0302). There was a significant association between the IL11-572 G→C polymorphism and bone mineral density in the lumbar spine, with the CC genotype significantly higher with the GC (p = 0.0124) or GG (p = 0.0066) genotypes. These results suggest that the IL11-572 G→C polymorphism is associated with bone mineral density in the lumbar spine in Frence girls with AIS. © 2014 AENSI Publisher All rights reserved.