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Wang W.,China Medical University at Heping | Su J.,China Medical University at Heping | Kong D.,China Medical University at Heping | Pang J.,the 463rd Hospital of the Chinese PLA | Kang J.,China Medical University at Heping
Sleep and Breathing | Year: 2016

Purpose: Brainstem auditory evoked potential (BAEP) outcomes in obstructive sleep apnea syndrome (OSAS) patients are inconsistent in some studies because the affecting factors are not well controlled. This study aimed to evaluate BAEP of male and female patients with moderate and severe OSAS and further assess the possible factors influencing BAEP abnormalities. Methods: Polysomnography were applied to 118 subjects, composed of 84 OSAS patients and 34 control subjects (22 male, 12 female), during the night. OSAS groups included 40 moderate (32 male, 8 female) and 44 sever (36 male, 8 female) OSAS patients. Binaural BAEPs were performed for every subject before polysomnography. The comparison of BAEP among control, moderate, and severe OSAS groups was performed according to different gender. Independent sample t test was used to examine the difference between male and female groups. Pearson’s correlation was applied between BAEP parameters and age, body mass index, and sleep-related data in OSAS group. Results: Prolonged latencies of waves I, III, and V were observed in OSAS patients. They were significantly correlated with apnea hypopnea index, arousal index, and hypoxia-related parameters. Compared to female patients, male patients had longer latencies of waves III and V. For severe male OSAS patients, BAEP of right ear showed additional prolongations of IPLs of I–III and I–V than that of left ear, and the IPL of I–III was correlated with the severity of hypoxia. Conclusions: Moderate and severe OSAS patients showed abnormal BAEP which could be influenced by gender, nocturnal hypoxia, and arousal. © 2016 Springer-Verlag Berlin Heidelberg


PubMed | China Medical University at Heping and the 463rd Hospital of the Chinese PLA
Type: Journal Article | Journal: Sleep & breathing = Schlaf & Atmung | Year: 2016

Brainstem auditory evoked potential (BAEP) outcomes in obstructive sleep apnea syndrome (OSAS) patients are inconsistent in some studies because the affecting factors are not well controlled. This study aimed to evaluate BAEP of male and female patients with moderate and severe OSAS and further assess the possible factors influencing BAEP abnormalities.Polysomnography were applied to 118 subjects, composed of 84 OSAS patients and 34 control subjects (22 male, 12 female), during the night. OSAS groups included 40 moderate (32 male, 8 female) and 44 sever (36 male, 8 female) OSAS patients. Binaural BAEPs were performed for every subject before polysomnography. The comparison of BAEP among control, moderate, and severe OSAS groups was performed according to different gender. Independent sample t test was used to examine the difference between male and female groups. Pearsons correlation was applied between BAEP parameters and age, body mass index, and sleep-related data in OSAS group.Prolonged latencies of waves I, III, and V were observed in OSAS patients. They were significantly correlated with apnea hypopnea index, arousal index, and hypoxia-related parameters. Compared to female patients, male patients had longer latencies of waves III and V. For severe male OSAS patients, BAEP of right ear showed additional prolongations of IPLs of I-III and I-V than that of left ear, and the IPL of I-III was correlated with the severity of hypoxia.Moderate and severe OSAS patients showed abnormal BAEP which could be influenced by gender, nocturnal hypoxia, and arousal.


PubMed | The 463rd Hospital of the Chinese PLA
Type: Journal Article | Journal: PloS one | Year: 2013

Ischemia-modified albumin is an altered serum albumin that forms under conditions of oxidative stress, a state also associated with doxorubicin-induced myocardial injury.The aim of this study was to better assess diagnostic and prognostic significance of ischemia-modified albumin in patients with breast cancer undergoing doxorubicin chemotherapy.Blood samples were collected from 152 breast cancer patients before and after each cycle of doxorubicin chemotherapy to measure the serum levels of ischemia-modified albumin, cardiac troponin T and creatine kinase-MB. We also monitored cardiac function during a 12 month follow-up.There was a significant difference in ischemia-modified albumin levels before and after each cycle of chemotherapy and the ischemia-modified albumin concentration positively correlated with the cumulative dose of doxorubicin (r = 0.212, P < 0.05). The combination of ischemia-modified albumin with cardiac troponin T and creatine kinase-MB increased the sensitivity to 0.920 and the specificity to 0.830 in the diagnosis of doxorubicin-induced myocardial injury. The optimal cutoff for ischemia-modified albumin concentration was 112.09 U/ml. The rate of change for ischemia-modified albumin levels correlated negatively with the rate of change for left ventricular ejection fraction at one year (r = -0.221, P < 0.05).Ischemia-modified albumin may be a clinically potential new marker for diagnosing doxorubicin-induced myocardial injury, and is helpful to predict long-term impairment of cardiac function.

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