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Mao Z.-g.,the 463 Hospital of Chinese PLA | Chen Z.-H.,General Hospital of Shenyang Military Command | Han H.-g.,General Hospital of Shenyang Military Command
Chinese Journal of Tissue Engineering Research | Year: 2012

BACKGROUND: Tissue engineering construction technology provides a new approach for esophageal defect repair. OBJECTIVE: According to the literature retrieval results, to multivariately analyze the literatures on tissue-engineered esophagus through China National Knowledge Infrastructure (CNKI) database and Science Citation Index (SCI) database and to explore the future development tendency of tissue-engineered esophagus. METHODS: A retrieval was performed for the literature of tissue-engineered esophagus, using the key words of "esophagus, tissue engineering, esophageal epithelial cells, scaffold construction" between January 2002 and December 2011 in CNKI database and SCI database. The retrieval results were analyzed, and the trends were described in words and graphics. RESULTS AND CONCLUSION: (1)The literature of tissue-engineered esophagus between January 2002 and December 2011 was not too much. The overall number of literature had an upward trend from 2002 to 2011. (2)Journal of Clinical Rehabilitative Tissue Engineering Research published most papers in this field. There were 10 fund projects on the tissue-engineered esophagus. United States published more literature than other countries, which play an important role in the field of the tissue-engineered esophagus. Many of literatures were published from Medical University of Graz, Nanyang Technological University, and University of Washington. (3)This paper provides a valuable reference for researchers to understand the overview and present situation of this field. Source


Zhang Y.,the 463 Hospital of Chinese PLA | Han L.,Chinese PLA General Hospital | Pang J.,the 463 Hospital of Chinese PLA | Wang Y.,the 463 Hospital of Chinese PLA | Feng F.,General Hospital of Shenyang Military Command
Tumor Biology | Year: 2015

The microRNA miR-452 has been shown to function as a tumor suppressor. However, the cellular mechanism and potential application of miR-452-mediated cancer suppression remain great unknown. This study aims to identify how miR-452 acts in regulating non-small cell lung cancer (NSCLC) proliferation and metastasis. Expression of miR-452 via adenoviral (Ad) vector inhibits the proliferation, invasion, and migration of NSCLC cells A549 or H460. Our data also shows that miR-452 down-regulates the expression of Bmi-1 as well as pro-survival or anti-apoptosis regulators Survivin, cIAP-1, and cIAP-2. By such gene interference, miR-452 modulates NSCLC cell epithelial–mesenchymal transition (EMT) and further disrupts their migration and invasion. Moreover, miR-452 blocks the activation of PI3K/AKT pathway, which is also required for EMT process. These data reveal that miR-452 treatment could be a novel target or strategy for NSCLC treatment. © 2015 International Society of Oncology and BioMarkers (ISOBM) Source


Wang J.,the 463 Hospital of Chinese PLA | Yin Z.,the 463 Hospital of Chinese PLA | Wen H.,the 463 Hospital of Chinese PLA
Journal of Clinical Rehabilitative Tissue Engineering Research | Year: 2011

BACKGROUND: Stem cells under appropriate conditions can differentiate into neurons, astrocytes and oligodendrocytes, which may radically improve neurons loss and glial cell degeneration in cerebral palsy children, thus to improve brain function in children. OBJECTIVE: To retrospectively analyze the effects of stem cells from different sources on cerebral palsy children. METHODS: The first author searched PubMed and Wanfang databases (1992/2011) for articles concerning therapies for cerebral palsy and stem cells from different sources for cerebral palsy. RESULTS AND CONCLUSION: Neural stem cells for animal nerve injury repair have been a reported, but the clinical application of neural stem cells is still in clinical trials. Although embryonic, bone marrow blood, fetal cord blood, umbilical cord-derived stem cells have been applied to child cerebral palsy in some hospitals and a preliminary efficacy has been obtained, the specific evaluation criteria and long-term effects remain to be further studied. Source


Dai S.,the 463 Hospital of Chinese PLA | Guan G.-F.,Jilin University | Jia J.,the 463 Hospital of Chinese PLA | Li H.,the 463 Hospital of Chinese PLA | And 6 more authors.
Acta Oto-Laryngologica | Year: 2016

Abstract: Conclusion: BDET might be effective for the patients with OME, and proved to be an efficacious and mini-invasive treatment for OME. Objectives: To evaluate the therapeutic benefits of balloon dilation eustachian tuboplasty (BDET) in the treatment of adult patients with otitis media with effusion (OME) caused by eustachian tube dysfunction (ETD). Methods: After informed consent, eight adult patients with OME were included in this study. After investigated patients’ case history and oto-function, all patients underwent BDET treatment. Then four criteria including tympanic membrane, pure tone audiometry (PTA), tympanometry, and subjective symptoms were adopted to evaluate the therapeutic benefits of BDET. Results: None of the involved patients complained of problems or complications during the post-operative period, or with absence of pain and bleeding after the operation. Prominent post-operative improvement was observed in tympanic membrane and otoscopic appearance. In addition, cure rates after 3 months and 6 months post-operatively were gradually increased. © 2016 Acta Oto-Laryngologica AB (Ltd). Source

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