The 455th Hospital of Chinese PLA

Shanghai, China

The 455th Hospital of Chinese PLA

Shanghai, China
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Dong L.B.,The 455th Hospital of Chinese PLA | Li G.Q.,The 455th Hospital of Chinese PLA | Tian Z.H.,The 455th Hospital of Chinese PLA | Wang Z.M.,The 455th Hospital of Chinese PLA | Xu K.,The 455th Hospital of Chinese PLA
Genetics and Molecular Research | Year: 2013

We investigated the expression of Src homology 2 domain-containing phosphatase (SHP-2) in laryngeal carcinoma and its clinical significance. Expression of SHP-2 was detected by immunohistochemical staining in normal mucosal tissues and various grades of laryngeal carcinoma. We looked for possible correlations between expression of SHP-2 in laryngeal carcinoma and clinical staging and lymph node metastasis. Immunochemical staining results revealed that the SHP-2 expression was significantly higher (88.24%) in laryngeal carcinoma than in normal mucosal tissue (25%). Additionally, the expression of SHP-2 was significantly correlated with lymph node metastasis, but not with clinical stage and gender of patients with laryngeal carcinoma. Therefore, SHP-2 may be useful as a prognostic marker for laryngeal carcinoma and as a therapeutic target in laryngeal carcinoma treatment. © FUNPEC-RP.


Li Z.-Y.,The 455th Hospital of Chinese PLA | Gu J.-F.,The 455th Hospital of Chinese PLA | Ding W.,The 455th Hospital of Chinese PLA | Xi S.-J.,The 455th Hospital of Chinese PLA | And 3 more authors.
World Chinese Journal of Digestology | Year: 2016

AIM To evaluate the efficacy of locally endoscopic cytoreductive surgery in the treatment of advanced gastric cancer in elderly patients as well as its influence on prognosis. METHODS Elderly patients with advanced gastric cancer were assigned to either a treatment group to receive locally endoscopic cytoreductive surgery or a control group to receive best supportive care. The primary endpoints were response rate (RR) and overall survival (OS). The efficacy and safety were evaluated after four complete courses of locally endoscopic cytoreductive surgery. Multivariate Coxregression analysiswas performedto determine survival trends adjusted for clinical and demographic factors. Kaplan-Meier curves were used to assess the differences in survival time. RESULTS A total of 106 elderly patients treated from January 1, 2010 to December 31, 2015 were enrolled, including 51 in the treatment group and 55 in the control group. The overall response rates of the two groups were 76.5% and 27.3%, respectively (P < 0.05). Coxregression analysis suggested that endoscopic cytoreductive surgery (P = 0.000) and tumor size (P = 0.000) were independent prognostic factors. Survival in the control group and treatment group showed a significant increase in median OS from 8.384 mo to 12.496 mo (P = 0.000).The hazard ratio of endoscopic cytoreductive surgery was 0.430 (95%CI: 0.274-0.675). Oneand two-year survival rates were 52.8% and 22.9% in the treatment group and 29.1% and 2.8% in the control group, respectively. CONCLUSION Locally endoscopic cytoreductive surgery has important value in improving the prognosis of elderly patients with advanced gastric cancer, and it shows survival benefit for advanced gastric cancer and prolongs the OS. © 2016 Baishideng Publishing Group Inc. All rights reserved.


PubMed | The 455th Hospital of Chinese PLA
Type: Journal Article | Journal: Genetics and molecular research : GMR | Year: 2013

We investigated the expression of Src homology 2 domain-containing phosphatase (SHP-2) in laryngeal carcinoma and its clinical significance. Expression of SHP-2 was detected by immunohistochemical staining in normal mucosal tissues and various grades of laryngeal carcinoma. We looked for possible correlations between expression of SHP-2 in laryngeal carcinoma and clinical staging and lymph node metastasis. Immunochemical staining results revealed that the SHP-2 expression was significantly higher (88.24%) in laryngeal carcinoma than in normal mucosal tissue (25%). Additionally, the expression of SHP-2 was significantly correlated with lymph node metastasis, but not with clinical stage and gender of patients with laryngeal carcinoma. Therefore, SHP-2 may be useful as a prognostic marker for laryngeal carcinoma and as a therapeutic target in laryngeal carcinoma treatment.

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