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Chengdu, China

Nie W.,Shanghai University | Zhang Y.,The 452nd Hospital of PLA | Jee S.H.,Yonsei University | Jung K.J.,Yonsei University | And 2 more authors.
BMC Medicine | Year: 2014

Background: It is unclear whether an 'obesity survival paradox' exists for pneumonia. Therefore, we conducted a meta-analysis to assess the associations between increased body mass index (BMI), pneumonia risk, and mortality risk. Methods: Cohort studies were identified from the PubMed and Embase databases. Summary relative risks (RRs) with their corresponding 95% confidence intervals (CIs) were calculated using a random effects model. Results: Thirteen cohort studies on pneumonia risk (n = 1,536,623), and ten cohort studies on mortality (n = 1,375,482) were included. Overweight and obese individuals were significantly associated with an increased risk of pneumonia (RR = 1.33, 95% CI 1.04 to 1.71, P = 0.02, I2 = 87%). In the dose-response analysis, the estimated summary RR of pneumonia per 5 kg/m2 increase in BMI was 1.04 (95% CI 1.01 to 1.07, P = 0.01, I2 = 84%). Inversely, overweight and obese subjects were significantly associated with reduced risk of pneumonia mortality (RR = 0.83, 95% CI 0.77 to 0.91, P < 0.01, I2 = 34%). The estimated summary RR of mortality per 5 kg/m2 increase in BMI was 0.95 (95% CI 0.93 to 0.98, P < 0.01, I2 = 77%). Conclusions: This meta-analysis suggests that an 'obesity survival paradox' exists for pneumonia. Because this meta-analysis is based on observational studies, more studies are required to confirm the results. © 2014 Nie et al.; licensee BioMed Central Ltd. Source

Tao C.-Y.,University of Sichuan | Wei P.,The 452nd Hospital of PLA | Wang J.-J.,University of Sichuan | You C.,University of Sichuan
Turkish Neurosurgery | Year: 2015

Intracranial epidermoid cysts are usually located in the paramedian regions with characteristic imaging features. Intracystic hemorrhage is rarely reported with most in the cerebellopontine angle area. We described a case of hemorrhagic epidermoid cyst in cerebellar vermis. The patient was a 21-year-old male presenting with a first episode of convulsive seizure attack as the initial and sole symptom. Head computed tomography showed a mass lesion in the cerebellar vermis with high density and nodular low density in the back of the lesion. Magnetic resonance imaging revealed most of the lesion was hypointense to isointense, extremely hypointensity on T1-, T2-weighted imaging respectively. The nodule was hyperintense on both T1- and T2-weighted images. The atypical clinical presentation, location and radiological features of intracranial epidermoid cyst make accurate diagnosis quite challenging. In such cases, scrutinized histopathological examination is necessary to exclude the malignancy that may need radio/chemotherapy. Source

Peng Y.,Sichuan University | Yang Y.,Sichuan University | Liu Y.,The 452nd Hospital of PLA | Nie Y.,Sichuan University | And 4 more authors.
Microbial Pathogenesis | Year: 2015

The prevalence of cholesterol gallstones has increased in recent years. Bacterial infection correlates with the formation of gallstones. We studied the composition and function of bacterial communities in cholesterol gallstones and bile from 22 cholesterol gallstone patients using culture-dependent and culture-independent methods. Altogether fourteen and eight bacterial genera were detected in cholesterol gallstones and bile, respectively. Pseudomonas spp. were the dominant bacteria in both cholesterol gallstones and bile. As judged by diversity indices, hierarchical clustering and principal component analysis, the bacterial communities in gallstones were different from those in bile. The gallstone microbiome was considered more stable than that of bile. The different microbial communities may be partially explained by differences in their habitats. We found that 30% of the culturable strains from cholesterol gallstones secreted β-glucuronidase and phospholipase A2. Pseudomonasaeruginosa strains showed the highest β-glucuronidase activity and produced the highest concentration of phospholipase A2, indicating that Ps. aeruginosa may be a major agent in the formation of cholesterol gallstones. © 2015 Elsevier Ltd. Source

Zhou L.-F.,The 452nd Hospital of PLA | Zhou L.-F.,University of Electronic Science and Technology of China | Shi Y.-B.,University of Electronic Science and Technology of China | Zhang W.,University of Electronic Science and Technology of China
Kongzhi yu Juece/Control and Decision | Year: 2010

In order to enhance the global convergence ability and the convergence speed of particle swarm optimization (PSO), based on the results of reference, an improved strategy is proposed. Inspired by the effect of individual experience in animal groups on the move, the whole searching process is departed into two steps, the exploration search with leadership and the exploitation search. The mutation operator is used to add the diversity of swarm. By analyzing five benchmark functions, the improved method is compared with two famous PSO methods. And the variance analysis of statistic theory is applied to compare the performance of the three methods. Experimental simulation results show that the proposed algorithm can not only significantly speed up the convergence, but also effectively solve the premature convergence problem. Source

Zhi Y.,Chongqing Medical University | Yu J.,Chongqing Medical University | Liu Y.,The 452nd Hospital of PLA | Wei Q.,Chongqing Medical University | And 5 more authors.
International Journal of Medical Sciences | Year: 2012

DNA repair is a primary defense mechanism against damage caused by exogenous and endogenous sources. We examined the associations between bladder cancer and 7 polymorphisms from 5 genes involved in the maintenance of genetic stability (MMR: MLH1-93G>A; BER: XRCC1--77T>C and Arg399Gln; NER:XPC Lys939Gln and PAT +/-; DSBR:ATM G5557A and XRCC7 G6721T) in 302 incident bladder cancer cases and 311 hospital controls. Genotyping was done using a polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) technique. The homozygous variant of XRCC7 G6721T (Odds Ratio [OR]: 2.36; 95% Confidence Interval [CI]: 1.13-4.92) was associated with increased bladder cancer risk. In an analysis of combined genotypes, the combination of XRCC1Arg399Gln (Gln allele) with XRCC1-77 T/T led to an increase in risk (OR: 1.61; 95% CI: 1.10-2.36). Moreover, when the XPCLys939Gln (Gln allele) (nucleotide excision repair [NER]) was present together with XRCC7 (T allele) (double strand break repair [DSBR]), the bladder cancer risk dramatically increased (OR: 4.42; 95% CI: 1.23-15.87). Our results suggest that there are multigenic variations in the DNA repair pathway involved in bladder cancer susceptibility, despite the existence of ethnic group differences. © Ivyspring International Publisher. Source

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