The 452nd Hospital of PLA

Chengdu, China

The 452nd Hospital of PLA

Chengdu, China

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Cao Y.-L.,The 452nd Hospital of PLA | Huang M.-T.,The 452nd Hospital of PLA | Feng Z.-M.,The 452nd Hospital of PLA
Chinese Journal of Interventional Imaging and Therapy | Year: 2014

Esophageal stenosis directly impacts the patients' life quality and seriously threats the patients' life safety. Application of the esophageal stent, espectially the biodegradable esophageal stent brings benefits for the patients of esophageal stenosis. The biodegradable esophageal stent included SX Ella-BD stent, polylactic acid stent and poly (ε-caprolactone-co-DL-lactide) copolymer stent. The essentiality, necessity and research progresses of the biodegradable esophageal stent were reviewed in this paper. Copyright © 2014 by the Press of Chinese Journal of Medical Imaging and Technology.


Nie W.,Shanghai University | Zhang Y.,The 452nd Hospital of PLA | Jee S.H.,Yonsei University | Jung K.J.,Yonsei University | And 2 more authors.
BMC Medicine | Year: 2014

Background: It is unclear whether an 'obesity survival paradox' exists for pneumonia. Therefore, we conducted a meta-analysis to assess the associations between increased body mass index (BMI), pneumonia risk, and mortality risk. Methods: Cohort studies were identified from the PubMed and Embase databases. Summary relative risks (RRs) with their corresponding 95% confidence intervals (CIs) were calculated using a random effects model. Results: Thirteen cohort studies on pneumonia risk (n = 1,536,623), and ten cohort studies on mortality (n = 1,375,482) were included. Overweight and obese individuals were significantly associated with an increased risk of pneumonia (RR = 1.33, 95% CI 1.04 to 1.71, P = 0.02, I2 = 87%). In the dose-response analysis, the estimated summary RR of pneumonia per 5 kg/m2 increase in BMI was 1.04 (95% CI 1.01 to 1.07, P = 0.01, I2 = 84%). Inversely, overweight and obese subjects were significantly associated with reduced risk of pneumonia mortality (RR = 0.83, 95% CI 0.77 to 0.91, P < 0.01, I2 = 34%). The estimated summary RR of mortality per 5 kg/m2 increase in BMI was 0.95 (95% CI 0.93 to 0.98, P < 0.01, I2 = 77%). Conclusions: This meta-analysis suggests that an 'obesity survival paradox' exists for pneumonia. Because this meta-analysis is based on observational studies, more studies are required to confirm the results. © 2014 Nie et al.; licensee BioMed Central Ltd.


Gan L.,Fudan University | Xu M.,Fudan University | Zhang Y.,The 452nd Hospital of PLA | Zhang X.,Shanghai University | Guo W.,Fudan University
Tumor Biology | Year: 2014

As the discovery of functions of long noncoding RNA (lncRNA) HOTAIR lifts ncRNA to new levels, large numbers of research have been demonstrated for the roles of lncRNAs in diverse biological processes, such as development, cellular differentiation, and a wide range of diseases including cancer. And, recent studies have discovered that lncRNAs can participate in almost every step in the life cycle of gene regulation, including chromosome dosage compensation, imprinting, epigenetic regulation, nuclear and cytoplasmic trafficking, transcription, mRNA splicing, and translation, mainly in the four archetypes—signals, decoys, guides, and scaffolds. Unsurprisingly, accumulating studies have demonstrated that serious lncRNAs are dysregulated in gastric cancer (GC), one of the major causes of cancer-related mortality worldwide, and closely related to tumorigenesis, metastasis, or prognosis. In this review, we will discuss diverse functions of lncRNAs and highlight the growing evidence for the important roles of lncRNAs acting as biomarkers for the early diagnosis of GC, as indicators of GC prognosis, or even as therapeutic targets in GC. © 2014, International Society of Oncology and BioMarkers (ISOBM).


He C.,The 452nd Hospital of PLA | Fang H.,The 452nd Hospital of PLA | Liu Y.,The 452nd Hospital of PLA | Huang X.,Chongqing Medical University | And 2 more authors.
World Journal of Surgical Oncology | Year: 2012

Pulmonary sclerosing hemangioma (PSH) is a rare benign tumor of the lungs. These tumors are composed of cuboidal surface cells and polygonal stromal cells and show four histological manifestations: hemorrhagic, papillary, solid, and sclerotic. PSH predominantly affects asymptomatic middle-aged women. The tumor often occurs at the intralobar site, and less commonly in the bronchus and mediastinum. PSH is easy to be misdiagnosed preoperatively. In this study, we present in detail the treatment procedures followed for two atypical cases of PSH. Case 1 was a 62-year-old woman bearing a tumor for 15 years. The tumor lesion was found to be located in the oblique fissure of the left lung. PSH was confirmed by surgical resection and postoperative pathological diagnosis. There was no sign of recurrence and metastasis 1.5 years after surgery. Case 2 was a 54-year-old woman diagnosed with bilateral multiple nodules by physical examination. This patient was diagnosed with definite PSH through computed tomography-guided percutaneous lung biopsy. Surgical resection was not performed. The patient also showed no sign of enlarged tumor and metastasis after 2 years of follow-up. Although PSH can be cured by surgical resection, the findings in our cases indicate that surgical resection need not be considered the preferred course of treatment. If PSH is diagnosed before surgery, the patients may survive while bearing the tumor. © 2012 He et al.; licensee BioMed Central Ltd.


Peng Y.,Sichuan University | Yang Y.,Sichuan University | Liu Y.,The 452nd Hospital of PLA | Nie Y.,Sichuan University | And 4 more authors.
Microbial Pathogenesis | Year: 2015

The prevalence of cholesterol gallstones has increased in recent years. Bacterial infection correlates with the formation of gallstones. We studied the composition and function of bacterial communities in cholesterol gallstones and bile from 22 cholesterol gallstone patients using culture-dependent and culture-independent methods. Altogether fourteen and eight bacterial genera were detected in cholesterol gallstones and bile, respectively. Pseudomonas spp. were the dominant bacteria in both cholesterol gallstones and bile. As judged by diversity indices, hierarchical clustering and principal component analysis, the bacterial communities in gallstones were different from those in bile. The gallstone microbiome was considered more stable than that of bile. The different microbial communities may be partially explained by differences in their habitats. We found that 30% of the culturable strains from cholesterol gallstones secreted β-glucuronidase and phospholipase A2. Pseudomonasaeruginosa strains showed the highest β-glucuronidase activity and produced the highest concentration of phospholipase A2, indicating that Ps. aeruginosa may be a major agent in the formation of cholesterol gallstones. © 2015 Elsevier Ltd.


Zhou L.-F.,The 452nd Hospital of PLA | Zhou L.-F.,University of Electronic Science and Technology of China | Shi Y.-B.,University of Electronic Science and Technology of China | Zhang W.,University of Electronic Science and Technology of China
Kongzhi yu Juece/Control and Decision | Year: 2010

In order to enhance the global convergence ability and the convergence speed of particle swarm optimization (PSO), based on the results of reference, an improved strategy is proposed. Inspired by the effect of individual experience in animal groups on the move, the whole searching process is departed into two steps, the exploration search with leadership and the exploitation search. The mutation operator is used to add the diversity of swarm. By analyzing five benchmark functions, the improved method is compared with two famous PSO methods. And the variance analysis of statistic theory is applied to compare the performance of the three methods. Experimental simulation results show that the proposed algorithm can not only significantly speed up the convergence, but also effectively solve the premature convergence problem.


Zhi Y.,Chongqing Medical University | Yu J.,Chongqing Medical University | Liu Y.,The 452nd Hospital of PLA | Wei Q.,Chongqing Medical University | And 5 more authors.
International Journal of Medical Sciences | Year: 2012

DNA repair is a primary defense mechanism against damage caused by exogenous and endogenous sources. We examined the associations between bladder cancer and 7 polymorphisms from 5 genes involved in the maintenance of genetic stability (MMR: MLH1-93G>A; BER: XRCC1--77T>C and Arg399Gln; NER:XPC Lys939Gln and PAT +/-; DSBR:ATM G5557A and XRCC7 G6721T) in 302 incident bladder cancer cases and 311 hospital controls. Genotyping was done using a polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) technique. The homozygous variant of XRCC7 G6721T (Odds Ratio [OR]: 2.36; 95% Confidence Interval [CI]: 1.13-4.92) was associated with increased bladder cancer risk. In an analysis of combined genotypes, the combination of XRCC1Arg399Gln (Gln allele) with XRCC1-77 T/T led to an increase in risk (OR: 1.61; 95% CI: 1.10-2.36). Moreover, when the XPCLys939Gln (Gln allele) (nucleotide excision repair [NER]) was present together with XRCC7 (T allele) (double strand break repair [DSBR]), the bladder cancer risk dramatically increased (OR: 4.42; 95% CI: 1.23-15.87). Our results suggest that there are multigenic variations in the DNA repair pathway involved in bladder cancer susceptibility, despite the existence of ethnic group differences. © Ivyspring International Publisher.


Li J.,The 452nd Hospital of PLA | Xu Y.-H.,The 452nd Hospital of PLA | Lu Y.,The 452nd Hospital of PLA | Ma X.-P.,The 452nd Hospital of PLA | And 5 more authors.
Asian Pacific Journal of Cancer Prevention | Year: 2013

Purpose: Prostate cancer caused by the abnormal disorderly growth of prostatic acinar cells is the most prevalent cancer of men in western countries. We aimed to screen out differentially expressed genes (DEGs) and explore small molecule drugs for prostate cancer. Materials and Methods: The GSE3824 gene expression profile of prostate cancer was downloaded from Gene Expression Omnibus database which including 21 normal samples and 18 prostate cancer cells. The DEGs were identified by Limma package in R language and gene ontology and pathway enrichment analyses were performed. In addition, potential regulatory microRNAs and the target sites of the transcription factors were screened out based on the molecular signature database. In addition, the DEGs were mapped to the connectivity map database to identify potential small molecule drugs. Results: A total of 6,588 genes were filtered as DEGs between normal and prostate cancer samples. Examples such as ITGB6, ITGB3, ITGAV and ITGA2 may induce prostate cancer through actions on the focal adhesion pathway. Furthermore, the transcription factor, SP1, and its target genes ARHGAP26 and USF1 were identified. The most significant microRNA, MIR-506, was screened and found to regulate genes including ITGB1 and ITGB3. Additionally, small molecules MS-275, 8-azaguanine and pyrvinium were discovered to have the potential to repair the disordered metabolic pathways, abd furthermore to remedy prostate cancer. Conclusions: The results of our analysis bear on the mechanism of prostate cancer and allow screening for small molecular drugs for this cancer. The findings have the potential for future use in the clinic for treatment of prostate cancer.


Qiubei Z.,Changzheng Hospital | Cheng L.,The 452nd Hospital of PLA | Yaping X.,Changzheng Hospital | Shunzhang L.,Changzheng Hospital | Jingping F.,Changzheng Hospital
World Journal of Surgical Oncology | Year: 2012

Myxofibrosarcoma is a common sarcoma in the extremities of older people, but is rare in the head and neck region. Here, we report the case of a 42-year-old male patient in whom myxofibrosarcoma generated from the sinus piriformis. Histopathologically, the tumor was characterized by spindle cellular proliferation with moderate cellular density in fibromyxoid stroma. Immunohistochemically, the tumor cells showed positive reactivity for vimentin, Ki-67, smooth muscle actin, and CD34, but negative staining for S-100. Based on these results, the tumor was diagnosed as a low-grade myxofibrosarcoma. Resection of the tumor was performed via a transcervical approach. The patient's postoperative clinical course was uneventful and no local recurrence or distant metastasis has been found so far. The pathology, clinical characteristics, and treatment of myxofibrosarcoma are also reviewed. © 2012 Qiubei et al.; licensee BioMed Central Ltd.


PubMed | the 452nd Hospital of PLA
Type: Journal Article | Journal: Asian Pacific journal of cancer prevention : APJCP | Year: 2013

Prostate cancer caused by the abnormal disorderly growth of prostatic acinar cells is the most prevalent cancer of men in western countries. We aimed to screen out differentially expressed genes (DEGs) and explore small molecule drugs for prostate cancer.The GSE3824 gene expression profile of prostate cancer was downloaded from Gene Expression Omnibus database which including 21 normal samples and 18 prostate cancer cells. The DEGs were identified by Limma package in R language and gene ontology and pathway enrichment analyses were performed. In addition, potential regulatory microRNAs and the target sites of the transcription factors were screened out based on the molecular signature database. In addition, the DEGs were mapped to the connectivity map database to identify potential small molecule drugs.A total of 6,588 genes were filtered as DEGs between normal and prostate cancer samples. Examples such as ITGB6, ITGB3, ITGAV and ITGA2 may induce prostate cancer through actions on the focal adhesion pathway. Furthermore, the transcription factor, SP1, and its target genes ARHGAP26 and USF1 were identified. The most significant microRNA, MIR-506, was screened and found to regulate genes including ITGB1 and ITGB3. Additionally, small molecules MS-275, 8-azaguanine and pyrvinium were discovered to have the potential to repair the disordered metabolic pathways, abd furthermore to remedy prostate cancer.The results of our analysis bear on the mechanism of prostate cancer and allow screening for small molecular drugs for this cancer. The findings have the potential for future use in the clinic for treatment of prostate cancer.

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