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Xie M.,309 Hospital of the Peoples Liberation Army | Hu M.,General Hospital of the Peoples Liberation Army | Liu H.,General Hospital of the Peoples Liberation Army | Xiao H.,309 Hospital of the Peoples Liberation Army
Journal of Oral and Maxillofacial Surgery | Year: 2011

Purpose: To investigate the use of an internal self-activated distraction device made of titanium-nickel memory alloy to augment the mandibular alveolar ridge. Materials and Methods: Twelve adult mongrel canines were randomly divided into 4 groups. Groups I and II were sacrificed 1 month and 3 months after distraction, respectively. In group III (distraction-planting group), 2 implants were placed on both sides of the mandible 3 months after distraction. In group IV (control group), no implants were placed. X-rays were taken and histologic research was performed. Results: When the distraction device was in place, the transport segments were lifted up 3.0 to 4.5 mm immediately, and a range of 7.5 to 11.5 mm of augmentation was reached after 3 to 5 days of device activation. X-rays showed that bone mineral density increased, and new bone formed in the distraction area 1 month after distraction. Three months later, the bone mineral density of the distraction area was close to that of the surrounding alveolar bone. Histologic observation showed that collagen bundles initially formed in the distraction region and were followed by calcification and osteogenesis. X-rays showed that the implants were well integrated 3 months after implant placement. The implant-bone interface showed bony integration, and there was no significant difference in the implant-bone contact rate between the distraction and control sides. Conclusion: The titanium-nickel memory alloy distractor can be used successfully to augment the posterior mandibular alveolar ridge of canines. New bone formed between the buccal and lingual periosteal layers. A conventional implant surgical procedure could be performed 3 months later and the desirable implant-bone integration was produced. © 2011 American Association of Oral and Maxillofacial Surgeons. Source

Wang W.,309 Hospital of the Peoples Liberation Army | Song Z.-J.,309 Hospital of the Peoples Liberation Army | Ding H.,309 Hospital of the Peoples Liberation Army | Duan X.-H.,309 Hospital of the Peoples Liberation Army | And 2 more authors.
Chinese Journal of Emergency Medicine | Year: 2011

Objective To analyze the distribution of main lesion areas in pulmonary fibrosis induced by paraquat in rats by means of radiographic imaages and varied CT value by using Micro CT. Methods A total of 15 male Sprague Dawley rats were randomly (random number) divided into control group and paraquat poisoned group, group. The rats in exposure group were treated with dilute solution of paraquat (4mg/ mL) in dose of 14mg/kg injected intraperitoneally, and the rats in control group were treated with the same volume of saline instead. The lung tissues of all rats were scanned in vivo by using MicroCT on the 3th , 7th , 14th and 28th days after paraquat or saline administration, respectively. The data from scanned images, rates of observable signs of pulmonary fibrosis and average CT value variation in given regions ( region of interest, ROI) were compared between groups and different durations after poisoning by using statistical methods as one factor analysis of variance (t-test). Results Compared with the control group, the rats with acute paraquat poisoning appeared varying degrees of the signs of pulmonary fibrosis. Most of the lesion areas predominantly spread over the lateral regions of the lower lobe of lung, and appeared mainly one week after paraquat poisoning. The opacity of lung shadow seen on the radiograph was significantly increased with time extended after exposure to PQ as a consequence of CT value variation in ROI, and there was no difference in the development of pulmonary fibrosis between right lung and left lung ( P > 0.05 ) , but there were differences in the extent of fibrosis at different areas in lung ( P < 0.05 or P < 0.01 ). Conclusions The signs of pulmonary fibrosis predominantly appeared one week after poisoning. The opacity of lung shadow was increasing gradually during the course of pulmonary fibrosis developed in rats in paraquat poisoning group, and lesion areas predominantly spread over the lateral regions of the lower lube of lung. Source

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