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Shenyang, China

Li C.-J.,The 202 Hospital of PLA | Wu Y.,The 202 Hospital of PLA | Zhang C.-J.,The 202 Hospital of PLA | Tong T.-B.,The 202 Hospital of PLA | Shang C.,The 202 Hospital of PLA
Chinese Journal of Tissue Engineering Research | Year: 2014

BACKGROUND: Arsenic trioxide is considered to inhibit the proliferation of vascular smooth muscle cells and promote cell apoptosis. Therefore, we wondered whether the arsenic can inhibit the hyperplasia of vascular smooth muscle cells, an arsenic-coated stent can be compatible with the vascular tissue, and a better vascular intimal coverage as early as possible can reduce intimal hyperplasia. OBJECTIVE: To observe the vascular histocompatibility of the arsenic-coated stent. METHODS: Fourteen white rabbits were randomized into two groups and respectively subject to the implantation of arsenic-coated 316 L stainless steel stents and bare 316 L stainless steel stents into the abdominal aorta. After28 days, the distal and proximal parts of the vessel at the implantation site were ligated and the ligated vessel was taken for hematoxylin-eosin staining and light microscope observation. RESULTS AND CONCLUSION: (1) Gross observation: the vessel at the stent site was a little larger than the adjacent vessels in the outer diameter, which was expanded but had no visible thrombus. After cutting the stent, the neointima formed smoothly on the stent surface. (2) Light microscope observation: the stent was located in the middle of the vessel, the medial smooth muscle was pressed, and vascular intimal smooth muscle hyperplasia was found around the stent, thereby thickening the vascular intima. The vascular neointima formed and covered the stent, and there was a thin black layer between the stent and the vascular tissue, which consisted of arsenic and its compounds. These findings suggest that the arsenic-coated stents can be covered with vascular tissues, possessing good vascular histocompatibility.

Lai J.-Y.,The 202 Hospital of PLA | Chen Z.-Z.,The 202 Hospital of PLA | Wang R.-C.,The 202 Hospital of PLA | Jia C.-W.,The 202 Hospital of PLA | And 2 more authors.
Chinese Journal of Tissue Engineering Research | Year: 2014

BACKGROUND: For depressed skull fractures in children, retaining their skull and narrowing surgical incision meet the concept of minimally invasive surgery as important as ensuring the surgical safety and therapeutic effects, which is also the requirement of children's parents. OBJECTIVE: To explore the curative effects of in suit replantation of free bone fragments based on a small incision in children with depressed skull fractures. METHODS: Fifteen patients with depressed skull fractures, aged 3-16 years, were selected and subject to CT examination and manual examination of the scalp at fractured site under general anesthesia for labeling fracture range. Then, one or two bone fragments corresponding to the fracture site and size were selected. A small incision with a length equal to the outer edge of bone fragments removed. Postoperative follow-up was employed for observation of clinical effects. RESULTS AND CONCLUSION: An incision, 5-7 cm in length, were made, and one bone fragment was removed from six cases, and two bone fractures were removed from nine cases. Intraoperatively, there were six cases of epidural hematoma, three cases of subdural hematoma, six cases of brain contusion and bleeding. For fracture fixation, one skull lock was used in eight cases, two skull locks in six cases, and three bone plates in one cases. Postoperative CT showed 12 cases of good fracture reduction displayed basic symmetry with the contralateral skull; 3 cases showed partially depressed bone fragments that were less than 0.5 cm; 6 cases had a little skull defects with a diameter < 1.0 cm; 6 cases had mild epidural hematoma or effusion which was eliminated after conservative treatment. Eleven of 15 cases were followed for 2 month to 3 years, and showed no changes in skull shape on CT films compared with those at discharge and presented with good stability. In addition, there were one case of mild limb paralysis, one case of mild language barriers, and one case of mild seizures, but all these cased were well controlled by drugs. These findings indicate that in situ replantation of partially free bone fragments is suitable for depressed skull fractures in children.

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