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Quanzhou, China

Wen D.-Z.,The 180th Hospital of PLA | Huang J.-H.,Wenzhou Medical College | Tu R.-X.,Wenzhou Medical College
International Eye Science | Year: 2015

AIM: To investigate the difference of retinal nerve fiber layer (RNFL) thickness measured with OCT between obstructive sleep apnea (OSA) patients and normal people and discuss the relativity between decresse of RNFL and OSA. METHODS: The articles on the association of RNFL thickness and OSA were retrieved by searching international and national databases. The qualified articles were assessed by Meta-analysis with Stata11.0 software. RESULTS: Totally 10 studies enrolled 1 488 eyes were included in the Meta-analysis. The results of Meta-analysis showed that in OSA patients, there was a significant average RNFL thickness reduction compared with the control group. There were significant differences in superior, nasal and inferior RNFL thickness between the two groups. WMD with a 95%CI were [-2.97, 95%CI: (-4.65~-1.30), P<0.01], [-3.05, 95%CI: (-4.93~-1.17), P=0.002], [-3.81, 95%CI: (-6.95~-0.68), P=0.02], [-4.16, 95%CI: (-7.63~-0.68), P=0.02] respectively. CONCLUSION: RNFL thickness is reduced in OSA patients compared with the control group. OCT may become a standard part of the evaluation of patients in OSA. ©, 2015, International Journal of Ophthalmology (c/o Editorial Office). All right reserved.

Wu X.-Y.,The 180th Hospital of PLA | Jiang L.-Z.,Guangxi Medical University
International Eye Science | Year: 2015

AIM: To evaluate the effects of intracameral cefuroxime injection on the prophylaxis of postoperative endophthalmitis after cataract surgeries, and compare endophthalmitis conditions between intracameral cefuroxime injection group and no intervention control group, using Meta analysis to search literatures at home and abroad. METHODS: By searching through Pubmed, the Cochrane Library, EMBASE, QVIP, CNKI, Wanfang, the literatures published from January 1st 2006 to January 31rd 2015 were collected. The data in five literatures about the effects of intracameral cefuroxime injection on the prophylaxis of endophthalmitis after cataract surgeries were analyzed. By extracting data, incidence of endophthalmitis after cataract surgeries with taking the preventive measures or not taking was compared by Review Manager 5.2.Adopting fixed effect model, values of odds ratio (OR) and 95% Confidence Interval (95%CI) were recorded and compared, analyzed sensitivity analysis, excluded heterogeneity and calculated outcomes. RESULTS: After comparing the incidence of endophthalmitis from intracameral cefuroxime injection group and control group, the result was statistically significant [OR=0.11 (P<0.01); 95% CI: 0.07~0.18]. CONCLUSION: Intracameral cefuroxime injection can effectively decrease the occurrence of endophthalmitis after cataract surgeries. Copyright 2015 by the IJO Press.

Fu M.,The 180th Hospital of PLA
American Journal of Therapeutics | Year: 2015

Statins have been used to prevent contrast-induced nephropathy (CIN). However, the optimal dose of statins is still under controversy. This study aimed to investigate the optimal dose of atorvastatin for the treatment of CIN after carotid artery stenting (CAS). Seventy-six patients receiving selective CAS were randomized to receive 3 different dose of atorvastatin (low dose, 20 mg, n = 30; intermediate dose, 40 mg, n = 24; high dose, 60 mg, n = 22). Preoperatively and on day 3 postoperatively, the levels of serum creatinine, blood urea nitrogen, high-sensitivity C-reactive protein (hs-CRP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), and creatine kinase (CK) were measured. Creatinine clearance (Ccr) and CIN incidence were calculated. In patients treated with high-dose atorvastatin, no significant change was observed in levels of serum creatinine (Scr), blood urea nitrogen (BUN), creatinine clearance, and high-sensitivity C-reactive protein after the CAS procedure (P > 0.05). The CIN incidence in the high-dose group (0%) was significantly lower than the low-dose (13.3%) and intermediate (8.3%) groups (P < 0.05). In the high-dose group, levels of alanine aminotransferase, aspartate aminotransferase, and creatine kinase were significantly increased after CAS (P < 0.05). Pretreatment with 40 mg of atorvastatin is both effective and safe in preventing CIN after CAS. Adverse events of the live and heart should be closely monitored during atorvastatin treatment. Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.

Li W.,The 180th Hospital of PLA | Wei R.,The 180th Hospital of PLA
Zhonghua Shiyan Yanke Zazhi/Chinese Journal of Experimental Ophthalmology | Year: 2014

Background: Transscleral diode laser cyclophotocoagulation (TDCP) was used to later stage of glaucoma in the past. However, the indications of TDCP are expanding gradually over time and there are more and more reports about its application in different stages and different types of glaucoma. Objective: This study was to compare the clinical efficacy of TDCP and trabeculectomy for primary acute angle-closure glaucoma (PAACG) with persistent ocular hypertension. Methods: Ninety-five PAACG patients with persistent ocular hypertension were retrospectively analyzed. The patients were divided into TDCP group (62 eyes of 56 cases) and trabeculectomy group (44 eyes of 39 cases) based on the difference of treating fashions. The clinical outcomes were compared between the two groups with the evaluating indexes of visual acuity, intraocular pressure (IOP) before and 1 week, 3 months and the end of following-up as well as the number of drug used and the re-treatment. Results: The demography was matched between the two groups (all at P≤0.05). The number of eyes with visual improvement was significantly different among the groups (χ2=30.927, P=0.002) in the TDCP group. Compared with before treatment, the number of visual improvement in 1 week after treatment was significantly raised (χ2=16.778, P=0.002). No significant differences were seen in the eye number of visual improvement in various timepoints after treatment (all at P≤0.008). Also, the eye number of visual improvement was significantly different among the different timepoints (χ2=44.345, P<0.001), and statistically significant change was found between the preoperation and postoperative 1week (χ2=23.725, P<0.001). However, there were no significant differences in the eye number of visual improvement in various timepoints after operation each other (all at P≤0.008). The IOP was insignificantly altered among the groups at various timepoints (F=3.836, P=0.053), but the change was significantly different over time (Ftime=757.078, P<0.001). The postoperative IOP was significantly higher than that of preoperation in both groups (all at P<0.001). The proportion of eyes using lowering-IOP drugs was 48.4% in the TDCP group, and that in the trabeculectomy group was 27.3%, showing a significant difference between them (χ2=4.796, P=0.029). The re-therapy was performed in 20 eyes (32.3%) and 2 eyes (4.5%) in the TDCP group and the trabeculectomy group, respectively. Conclusions: The short-term lowing-IOP effecacy of TDCP is similar to trabeculectomy, but the long-term lowing-IOP efficacy of TDCP is not good. Compared with the trabeculectomy, TDCP shows more simple operation, less time-consuming during the surgery and milder tissue damage, but the eyes continuing to use anti-glaucomatous drugs or re-therapy are increased. Copyright © 2014 by the Chinese Medical Association.

Xu J.-F.,The 180th Hospital of PLA | Chen K.-C.,The 180th Hospital of PLA
International Eye Science | Year: 2014

AIM: To investigate the efficiency and security of compound anisodine injection in the treatment of juxtafoveal central serous chorioretinopathy (CSC). METHODS: Sixty patients (60 eyes) who were diagnosed of juxtafoveal CSC were assigned randomly into 2 groups: 32 cases (32 eyes, therapeutic group) were injected subcutaneously compound anisodine injection for 2 mL q. d around superficial temporal arteries in the affected eyes; 28 cases (28 eyes, control group) received only traditional oral medication. Both groups received therapy for 2 to 4 courses of treatment. The main observations were the best corrected visual acuity (BCVA), subjective symptom, visual field, average light sensitivity and optical coherent topography (OCT). RESULTS: There was no significant difference between the therapeutic group and the control group before treatment (P>0.05), but all the outcome measures at 1, 3mo in the treatment group were significantly improved as compared with control group (P<0.05). After 6 mo, there were no significant difference between the two groups in all measures (P>0.05). No severe adverse reaction was noted except mild ones such as temporary dry mouth, dizziness and palpitation in a few cases. CONCLUSION: Compound anisodine injection has remarkable effects in the treatment of juxtafoveal CSC. It can shorten the course, improved the visual function and decreased the recurrence rate of CSC.

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