Dai Y.-C.,Xiamen University |
Dai Y.-C.,The 174th Hospital of the Chinese PLA |
Zhu X.-S.,Xiamen University |
Zhu X.-S.,The 174th Hospital of the Chinese PLA |
And 15 more authors.
World Journal of Gastroenterology | Year: 2012
AIM: To screen the differential expressed genes in colorectal cancer and polyp tissue samples. METHODS: Tissue specimens containing 16 cases of colorectal adenocarcinoma and colorectal polyp vs normal mucosae were collected and subjected to cDNA microarray and bioinformatical analyses. Quantitative reverse transcription-polymerase chain reaction (qRT-PCR) was used to confirm some of the cDNA microarray data. RESULTS: The experimental data showed that eight genes were differentially expressed, most of which were upregulated in adenomatous polyp lesions. Forty-six genes expressions were altered in colorectal cancers, of which 29 were upregulated and 17 downregulated, as compared to the normal mucosae. In addition, 18 genes were similarly altered in both adenomatous polyps and colorectal cancer. qRT-PCR analyses confirmed the cDNA microarray data for four of those 18 genes: MTA1, PDCD4, TSC1 and PDGFRA. CONCLUSION: These differentially expressed genes likely represent biomarkers for early detection of colorectal cancer and may be potential therapeutic targets after confirmed by further studies. © 2012 Baishideng. All rights reserved.
Tan Q.-H.,The 174th Hospital of the Chinese PLA |
Dai Y.-C.,The 174th Hospital of the Chinese PLA
World Chinese Journal of Digestology | Year: 2014
Pyloric stenosis is a common type of upper gastrointestinal obstruction, which is a result of progression of many diseases. This paper will review the common causes of pyloric stenosis and its non-surgical treatments, mainly endoscopic treatment, in recent years. With the development of endoscopic technology, endoscopic treatment will gradually replace surgical treatment for treatment of pyloric obstruction. © 2014 Baishideng Publishing Group Inc. All rights reserved.