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Song S.,Peoples Hospital of Jiangsu Province | Sun Z.-Z.,Peoples Hospital of Jiangsu Province | Rui Y.-J.,Peoples Hospital of Jiangsu Province | Cai F.-J.,The 101 Hospital of Chinese PLA | And 4 more authors.
Chinese Journal of Tissue Engineering Research | Year: 2013

BACKGROUND: At present, the observation index of the thoracolumbar burst fracture after pedicle instrument reset is the imaging examination of vertebral body basic form, and the reports on the changes of morphology of spinal canal after reduction are rare. OBJECTIVE: To analyze the changes of morphology of spinal canal after thoracolumbar fractures treated with pedicle screw rod system fixation and reduction. METHODS: Twenty-eight cases of thoracolumbar burst fracture treated with pedicle screw rod system fixation and reduction were followed-up after operation, and all patients took the thoracolumbar anteroposterior and lateral X-ray film before treatment, 1 week, 1 and 2 years after operation. All the patients underwent CT scans of the upper and lower vertebral body, of which 26 patients obtained the image data of CT scan before treatment, 1 week, 1 and 2 years after operation, and partial image information of two patients lost. Whether the fracture block of the posterior margin of vertebral body went into the spinal canal or not was identified on the thoracic and lumbar spine lateral X-ray film firstly, and the changes of spinal canal morphology were observed; the spinal median sagittal diameter measured based on the CT scanning image data represented the spinal space-occupying degree. RESULTS AND CONCLUSION: Lateral X-ray films of the 28 cases showed the fracture block of the posterior margin of vertebral body of 18 cases (64.2%) went into the spinal canal before operation, fracture block of six cases (21.4%) went into the spinal canal after operation, two cases (7.1%) at 1 year after operation, one cases (3.5%) at 2 years after operation; the average spinal median sagittal diameter was 42.6% (n=28) before operation. The spinal median sagittal diameter of the 26 cases with complete follow-up imaging data was 75.2% (P < 0.05), and the median sagittal diameter at 1 year after operation was 91.2% (n=26). The occupying reduction effect of spinal canal is obvious after thoracolumbar burst fracture treated with pedicle screw rod system fixation and reduction, the postoperative long-term observation shows the spinal canal morphology can be restored to normal. Source


Liu S.-k.,Jiangsu University | Yu X.-h.,Military Training Medical Institute of Nanjing Military Region | Wu Y.-y.,The 101 Hospital of Chinese PLA | Xu M.-m.,Jiangsu University | And 3 more authors.
Chinese Journal of Tissue Engineering Research | Year: 2012

BACKGROUND: Effects of keeping exercise after skeletal muscle contusion on regeneration of muscular tissue remain unclear. OBJECTIVE: To investigate the effects of treadmill running on the histopathology of skeletal muscle in SD rats with acute contusion. METHODS: A total of 64 male SD rats were randomly divided into four groups: normal control group, model group, natural healing group and exercise intervention group. Skeletal muscle contusion model in the middle part of the hindlimb gastrocnemius was constructed in the latter three groups. Rats in the exercise intervention group underwent treadmill exercise; rats in the natural healing group received normal feeding without exercise intervention. Rats in the model group were sacrificed at the 6th hour after model construction. RESULTS AND CONCLUSION: Massive inflammation cells were found in rat damaged muscle tissues of the natural healing group and exercise intervention group in the 24th hour to the 3rd day after acute gastrocnemius contusion injury; the inflammation decreased on the 5th day. The number of inflammation cells in the exercise intervention group was significantly larger than that in the natural healing group at different time points of the same period (P < 0. 05). The inflammation cells disappeared on the 7th day after injury in both groups. A small amount of scar tissue was found on the 5th day after injury in both groups, which increased gradually with time. The area of fibrous scar in the exercise intervention group was significantly larger than that in the natural healing group on the 7th to 14th days after injury (P < 0. 01); there was still a growing trend in the scar tissues of both groups on the 14th day after injury. It indicate that exercise can aggravate the local inflammation and lead to excessive formation of scar tissue in the early regeneration following acute contusion of skeletal muscle; it has a negative impact on the repair of skeletal muscle. Source


Zhang Y.-J.,Anhui Medical University | Yang C.-C.,Nanjing Medical University | Liu L.-K.,Nanjing Medical University | Zhang M.-J.,The 101 Hospital of Chinese PLA | Sun Y.-M.,The 101 Hospital of Chinese PLA
Chinese Journal of Tissue Engineering Research | Year: 2014

BACKGROUND: Low concentration of nicotine promotes the angiogenesis and facilitates the healing of skin wounds. However, the role of low concentration of nicotine on the repair of maxillofacial soft tissue trauma especially oral mucosa still remains unclear OBJECTIVE: To evaluate the effect of low concentration of nicotine on mucosa defect repair of rat hard palate. METHODS: A circular soft tissue defect at 3 mm diameter was produced in the centre of hard palate of 65 Wistar rats. After the operation, animals were randomly divided into low concentration of nicotine with gel group, gel group and control group. Rats were sacrificed at 3, 7, 10 and 14 days post-surgery. The wound healing was detected with hematoxylin-eosin staining and the difference of wound healing in different groups was compared with gross observation and image measurement. RESULTS AND CONCLUSION: There was no significant difference in the wound healing in different groups on day 3 post-surgery. On days 7 and 10, the group of low concentrations of nicotine with gel was faster than gel group and control group (P < 0. 05); the wounds were completely healed on day 14, with no significant difference among the groups. Low concentrations of nicotine may promote the mucosa defects repair of rat hard palate. Source


Wang J.-L.,The 101 Hospital of Chinese PLA | Xu K.-F.,The 101 Hospital of Chinese PLA
Chinese Journal of Tissue Engineering Research | Year: 2014

Background: Currently thoracolumbar fixation techniques have its advantages and disadvantages, it is necessary to explore a new internal fixation to fix the spine effectively and conveniently. Objective: To establish thoracolumbar (T12-L2) three-dimensional finite element model and observe the effect of anteroposterior integration fixation by posterolateral nail-stick system on thoracolumbar stability. Methods: Based on the CT scan data of normal human T12-L2 segments, we used Geomagic 11.0, Ug 7.0, Hypermesh 10.0, Abaqus 6.9.1 software to establish a three-dimensional finite element model of T12-L2 segments. Subsequently we established nail-stick system posterior fixation, anterior fixation, posterolateral anteroposterior integration fixation model. T12 segment was given 500 N preload and 7.5 N·m torque, to simulate thoracolumbar flexion, extension, lateral bending and rotation. The average rigidity of fixed segments under different conditions were observed. Results and Conclusion: Three fixation models showed a higher average rigidity than normal model under different conditions. The average rigidity in anteroposterior integration fixation by posterolateral nail-stick system was increased by 13%, 28%, 11%, 17% and 9%, compared with simple posterior fixation under the conditions such as anterior flexion, lateral bending and lateral rotation, respectively. Under the posterior extension, the average rigidity was reduced by 6% than the posterior fixation. Compared with the anterior fixation, the average rigidity in anteroposterior integration fixation by posterolateral nail-stick system was reduced by 15%, 10%, and 14% under the conditions of anterior flexion and lateral bending. While the average rigidity was higher than anterior flexion under the posterior extension and lateral rotation, increasing 5%, 12% and 2%. The anteroposterior integration fixation by posterolateral nail-stick system can improve the stability of fixed segments, and the stability is higher than anterior fixation at posterior extension and lateral rotation, while higher than posterior fixation in anterior flexion, lateral bending and lateral rotation. So it is a potential fixation method. © 2014, Journal of Clinical Rehabilitative Tissue Engineering Research. All rights reserved. Source


Zou M.,Anhui Medical University | Bai G.-f.,Anhui Medical University | Zhang Y.,The 101 Hospital of Chinese PLA | Li K.,The 101 Hospital of Chinese PLA | Luo Y.-c.,Anhui Medical University
Chinese Journal of Tissue Engineering Research | Year: 2012

BACKGROUND: Traditional dynamic hip screw (DHS), proximal femur nail anti-rotation (PFNA) and anatomic proximal femoral locking plate (APFLP) are used in internal fixation of intertrochanteric fractures, but now which one is best method for the treatment of intertrochanteric fractures is still controversial. OBJECTIVE: To investigate the clinical efficacy of the DHS, PFNA and APFLP for the treatment of the intertrochanteric fractures in old people. METHODS: Totally 159 elderly patients with intertrochanteric fractures were retrospectively analyzed. Difference of the DHS, PFNA and APFLP for the treatment of the intertrochanteric fractures was compared. RESULTS AND CONCLUSION: 1Harris hip function score in the PFNA group was better than that in the APFLP group (P < 0.05) which was superior to DHS group (P < 0.05) at 1 week, 6 months and 1 year after surgery. X-ray of fracture healing in the PFNA group was better than that in the APFLP group (P < 0.05) which was superior to the DHS group (P < 0.05) at 3, 6, 12 months after surgery. It is indicated that the PFNA for the treatment of intertrochanteric fractures has many advantages in less damage, stronger fixation, simpler operation, higher fracture healing, shorter healing time, better functional recovery and so on. It is the ideal fixation for intertrochanteric fractures in old people. Source

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