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Nooris M.,University of Mumbai | Aparna D.,Thakur College | Radha S.,University of Mumbai
European Biophysics Journal | Year: 2015

In this study, we report the synthesis and characterization studies of amine-functionalized MFe2O4 (Co, Ni, Mn) nanoparticles. The synthesis process was accomplished by refluxing metal chloride precursors in ethylene glycol in the presence of sodium acetate and ethanolamine. The average crystallite sizes of the synthesized particles are found to be in the range of 8–10 nm. The synthesized particles are characterized using X-ray diffraction, Brunauer–Emmett–Teller technique, FTIR, dynamic light scattering, Raman and UV–visible spectroscopy for crystal structure, average size, surface area, pore diameter and hydrodynamic diameter, phase and functional group determination. The surface morphology and elemental composition were studied by scanning electron microscope and X-ray fluorescence respectively. Magnetic behavior up to fields of 3 T at room temperature measured in Quantum Design Physical Property Measurement System (QD PPMS) magnetometer showed the superparamagnetic behavior of these particles. Modulation of angiogenesis by the nanoparticles was studied in a chick embryo chorioallantoic membrane model by analysis of blood vessel development and effect on hemoglobin level using imaging and colorimetric methods. An enhancement in the angiogenesis compared to the saline control was observed for all the ferrite nanoparticles with a relatively optimal activity in case of CoFe2O4 nanoparticles. © 2015 European Biophysical Societies' Association Source


Nirgude N.T.,Nb Mehta Science College | Shukla S.,Thakur College | Venkatachalam A.,P.A. College
Rasayan Journal of Chemistry | Year: 2013

Physico-chemical analysis of ground water samples collected from different sources from Vapi town, Gujarat for five months period from March 2009 to July 2009 has been carried out. However, only study of March 2009 is presented in this paper. The study showed the pollution effect of industrial effluents on ground water. The parameters like pH, Colour, EC, TDS, TH, BOD, COD, DO, Clminus,SO4 minus2, Na+1, K+1 Ca+2, Mg+2 have been studied for their concentration in the ground water Samples. Statistical study has been carried out by calculating the correlation coefficient between different parameters and applied for checking their significance. The observed values of physico-chemical parameters of water samples were compared with standard values recommended by WHO. The study revealed that all the physico-chemical parameters are well above the permissible limits suggested by WHO and USEPA for drinking water. Proper treatment methods are suggested for these ground water samples to be used for the drinking purpose; however they can be used for irrigation purpose. © 2013 RASĀYAN. All rights reserved. Source


Nirgude N.T.,Nb Mehta Science College | Shukla S.,Thakur College | Venkatachalam A.,Bhavans College andheri West
Rasayan Journal of Chemistry | Year: 2013

Physicochemical characteristics of some industrial effluents collected from various industries in and around Vapi Industrial Area. Industrial effluents were studied for five months intervals during Sep 2008-Jan 2009, however in this paper data is presented for the month of Jan 2009. In all 17 parameters were studied. These includes Colour, temperature, pH, electrical conductivity, TDS, TSS, BOD, COD, Chloride, sulphate, Nitrate, Phosphate, Calcium, Magnesium, Sodium and Potassium ions. The pollution levels from these industries were found to be very high and alarming and hence proper care must be taken for the treatment of these effluents before they are released to the sewage. Many big industries have their own effluent treatment plants, but small scale industries are not following the guidelines prescribed for the industrial effluents. The study has shown that almost all the parameters are on the higher levels than the prescribed limit and hence proper treatment methods are needed. © 2013 RASĀYAN. All rights reserved. Source


Momin N.,University of Mumbai | Deshmukh A.,Thakur College | Radha S.,University of Mumbai
Journal of Nano Research | Year: 2015

In this study, we report the synthesis and characterization studies of amine functionalized CoFe2O4 and NiFe2O4 nanoparticles (NPs). The synthesis process was accomplished by refluxing metal chloride precursors in ethylene glycol in presence of sodium acetate and ethanolamine. The average crystallite sizes of the synthesized particles are found to be in the range of 8-10 nm. The synthesized particles are characterized using X-ray diffraction (XRD), Brunauer-Emmett-Teller (BET) technique, FTIR, Raman and UV-visible spectroscopy for crystal structure, average size, surface area, phase and functional group determination. The surface morphology and elemental composition were studied by Scanning electron microscope (SEM) and X-ray fluorescence (XRF) respectively. Magnetic behavior upto fields of 3T at room temperature measured in PPMS magnetometer showed the superparamagnetic behavior of these particles. Analysis of cytotoxicity was carried out by examining their effect on cell viability of human peripheral blood lymphocytes so as to assess biocompatibility for various biomedical applications. Source


Deshmukh A.,Thakur College | Radha S.,University of Mumbai | Khan Y.,Sophia College | Tilak P.,University of Mumbai
AIP Conference Proceedings | Year: 2011

Nanoparticles are being explored in the targeted drug delivery of pharmacological agents: angiogenesis being one such novel application which involves formation of new blood vessels or branching of existing ones. The present study involves the use of ferrite nanoparticles for precise therapeutic modulation of angiogenesis. The ferrite nanoparticles synthesized by co-precipitation of ferrous and ferric salts by a suitable base, were found to be 10-20 nm from X-ray diffraction and TEM measurements. The magnetization measurements showed superparamagnetic behavior of the uncoated nanoparticles. These ferrite nanoparticles were found to be bio-compatible with lymphocytes and neural cell lines from the biochemical assays. The chick chorioallantoic membrane(CAM) from the shell of fertile white Leghorn eggs was chosen as a model to study angiogenic activity. An enhancement in the angiogenic activity in the CAM due to addition of uncoated ferrite nanoparticles was observed. © 2011 American Institute of Physics. Source

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