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Sophia K.,Thaimoogambigai Dental College | Suresh S.,Thaimoogambigai Dental College | Sudhakar U.,Thaimoogambigai Dental College | Jayakumar P.,Thaimoogambigai Dental College | Mathew D.,Thaimoogambigai Dental College
Journal of Clinical and Diagnostic Research | Year: 2017

Introduction: Alkaline phosphatase is an intracellular destruction enzyme in the periodontium, and it takes part in the normal turnover of the periodontal ligament, alveolar bone, and root cementum formation and maintenance. Aim: The aim of this case control study was to evaluate the enzyme Alkaline Phosphatase (ALP) level in saliva of post menopausal women with and without chronic periodontitis. Materials and Methods: In this study, 40 individuals, satisfying the study inclusion and exclusion criteria, were recruited. They were categorically divided, on the basis of gingival index, probing pocket depth and clinical attachment level, into two groups: Group I (post menopausal women with a clinically healthy periodontium, n=20); and Group II (post menopausal women with generalized chronic periodontitis, n=20). Clinical parameters assessed were Plaque Index (PI), Gingival Index (GI), Clinical Attachment Level (CAL) and Probing Pocket Depth (PPD). Unstimulated salivary samples were obtained in which the ALP concentration was measured using p-Nitrophenylphosphate, and 2-amino-2-methyl-1-propanol reagents in Beckman and Coulter, AU 480 auto analyser. Mann-Whitney U test was used to find statistical difference with respect to all clinical parameters such as PI, GI, CAL, PPD and salivary ALP levels. Results: The mean ALP in saliva was found to be higher in Group II compared to Group I and the difference was statistically significant with the p-value of 0.008. Conclusion: A noteworthy increase in the ALP concentration was seen in saliva in our study (Group II) may be due to increased periodontal inflammation in post menopausal women. Thus salivary ALP can be taken as an additional biomarker to early diagnosis, development and progression of periodontitis especially among post menopausal women. © 2017, Journal of Clinical and Diagnostic Research. All rights reserved.


Nithya S.,Thaimoogambigai Dental College | Sundaravel S.,Subburaj Hospital | Uppala D.,Gitam Dental College | Rao K.,Gitam Dental College
Journal of Oral and Maxillofacial Pathology | Year: 2015

Desmoplastic fibroma (DF) is a benign intra-osseous neoplasm, that is, recognized as the intra-osseous counterpart of soft tissue fibromatosis in both gnathic and extra-gnathic sites. It has a propensity for locally aggressive behavior and local recurrence. An occurrence of intra-osseous lesion other than that of odontogenic origin is rare in the jaws. In this case report, we define the clinico-pathological and radiographic features of DF of the mandible in a 35-year-old female, who presented to the Outpatient Department with a 3-year history of a slowly expanding painless mass in the left mandibular posterior region. Thus, we present a classic case of DF exhibiting characteristic features along with a review of the literature. © 2015 Journal of Oral and Maxillofacial Pathology.


PubMed | Thaimoogambigai Dental College, Subburaj Hospital and Gitam Dental College
Type: Journal Article | Journal: Journal of oral and maxillofacial pathology : JOMFP | Year: 2015

Desmoplastic fibroma (DF) is a benign intra-osseous neoplasm, that is, recognized as the intra-osseous counterpart of soft tissue fibromatosis in both gnathic and extra-gnathic sites. It has a propensity for locally aggressive behavior and local recurrence. An occurrence of intra-osseous lesion other than that of odontogenic origin is rare in the jaws. In this case report, we define the clinico-pathological and radiographic features of DF of the mandible in a 35-year-old female, who presented to the Outpatient Department with a 3-year history of a slowly expanding painless mass in the left mandibular posterior region. Thus, we present a classic case of DF exhibiting characteristic features along with a review of the literature.


Sudhakar U.,Thaimoogambigai Dental College | Ramakrishnan T.,Meenakshi Ammal Dental College | Rekha A.,Thaimoogambigai Dental College | Tamizhchelvan H.,Sri Ramachandra Dental College | And 3 more authors.
Biosciences Biotechnology Research Asia | Year: 2015

Chronic Periodontitis, an inflammatory disease caused by oral bacteria stimulates the host cells,neutrophils which release Reactive Oxygen Species(ROS) as a part of immune response. Excess ROS is one of the pathological features in the periodontal lesion.Recently, Reactive Oxygen Metabolites(ROM) were recognized as a useful measure of blood ROS .The aim of this study is to estimate the prevalence of ROM in Plasma, saliva and Gingival crevicular fluid in Chronic Periodontitis, chronic gingivitis and healthy controls. The study population consisted of 45 subjects belonging to both the sexes were randomly selected . Subjects were divided into three groups , Healthy periodontium ( HP)(Group I) and Chronic Gingivitis (CG)(Group II), Chronic Periodontitis(CP) ( Group III). GCF, saliva and plasma were collected in all the three groups to estimate the Reactive oxygen metabolite levels. ROM levels in plasma concentration were almost the same in all the groups [ pvalue 0.13]. The values obtained in saliva and GCF were significantly higher in Chronic Periodontitis group compared to Chronic Gingivitis and Healthy Periodontium.[ pvalue < 0.001]. The results of our study suggested that a significant oxidative stress may occur in Periodontitis. The findings also suggest that it might play an important role in the pathology of Periodontitis and the associated tissue damage.


Sudhakar U.,Thaimoogambigai Dental College | Ramakrishnan T.,Meenakshi Ammal Dental College | Rekha A.,Sri Ramachandra Dental College | Tamizhchelvan H.,Thaimoogambigai Dental College | And 3 more authors.
Biosciences Biotechnology Research Asia | Year: 2015

Chronic Periodontitis, an inflammatory disease caused by oral bacteria stimulates the host cells, neutrophils which release Reactive Oxygen Species(ROS) as a part of immune response. Excess ROS is one of the pathological features in the periodontal lesion. Recently, Reactive Oxygen Metabolites(ROM) were recognized as a useful measure of blood ROS .The aim of this study is to estimate the prevalence of ROM in Plasma, saliva and Gingival crevicular fluid in Chronic Periodontitis, chronic gingivitis and healthy controls. The study population consisted of 45 subjects belonging to sexes were randomly selected. Subjects were divided into three groups, Healthy periodontium (HP) (Group I) and Chronic Gingivitis (CG)(Group II), Chronic Periodontitis(CP) ( Group III). GCF, saliva and plasma were collected in all the three groups to estimate the Reactive oxygen metabolite levels. ROM levels in plasma concentration were almost the same in all the groups [ pvalue 0.13]. The values obtained in saliva and GCF were significantly higher in Chronic Periodontitis group compared to Chronic Gingivitis and Healthy Periodontium.[ pvalue < 0.001]. The results of our study suggested that a significant oxidative stress may occur in Periodontitis. The findings also suggest that it might play an important role in the pathology of Periodontitis and the associated tissue damage.


Suresh S.,Thaimoogambigai Dental College | Mahendra J.,Meenakshiammal Dental College | Singh G.,Sree Balaji Dental College | Pradeep A.R.,Thaimoogambigai Dental College | And 2 more authors.
Journal of Clinical and Diagnostic Research | Year: 2016

Introduction: Resistin is an adipocyte derived hormone that has been shown to play a substantial role in the development of insulin resistance. Resistin acts as a pro-inflammatory molecule and stimulates the synthesis and secretion of pro-inflammatory cytokines. Recent studies have reported the association of Gingival Crevicular Fluid (GCF) resistin levels with periodontal condition. Aim: The aim of this study was to assess and compare the GCF resistin levels in obese subjects with periodontal health and disease and to correlate the disease severity with GCF resistin levels. Materials and Methods: Ninety subjects of both the sexes with age between 20–45 years were selected for the study and were categorized into four groups: 25 obese or overweight subjects with generalized chronic periodontitis (Group-I), 25 obese or overweight subjects with healthy periodontium (Group-II), 25 non-obese subjects with generalized chronic periodontitis (Group-III) and 15 non obese subjects with healthy periodontium (Group-IV). The demographic variables like age, Body Mass Index (BMI), Waist Circumference (WC) were recorded and the clinical periodontal parameters such as Plaque Index (PI), Gingival Index (GI), and Clinical Attachment Level (CAL) were also assessed in all the groups. GCF was collected and assessed for resistin levels. Results: The mean GCF resistin levels in Groups I, II, III & IV were 15.14, 9.06, 12.74 and 5.41 ng/dl respectively and the difference in mean GCF resistin level was statistically significant with the p-value<0.001. The mean GCF resistin levels in Group-I was higher compared to Group II and III and the differences in mean GCF resistin levels were statistically significant. GCF resistin levels were positively correlated with BMI, WC and CAL in Group I and CAL correlated with GCF resistin in Group III and this correlation was statistically significant. Conclusion: From our study we report that obese subjects with periodontitis have more GCF resistin levels compared to non-obese subjects with healthy periodontium. © 2016, Journal of Clinical and Diagnostic Research. All Rights reserved.


Ramachandhra Prabhakar R.,Thaimoogambigai Dental College | Saravanan R.,Thaimoogambigai Dental College | Karthikeyan M.K.,Thaimoogambigai Dental College | Vishnuchandran C.,Thaimoogambigai Dental College | Sudeepthi,Thaimoogambigai Dental College
Journal of Clinical and Diagnostic Research | Year: 2014

Background: With the advent of functional appliances and orthopedic appliances the elimination and correction of skeletal and dental discrepancies has been much reduced. Most orthodontists agree that elimination of oral habits and orthopaedic treatment of class 3 malocclusion and posterior cross bites deserve treatment at an early age. Early treatment was proposed along the lines of "catch them in the young", and "you see it, you treat it" is the main ideology of Early Orthodonticc Treatment (EOT). Furthermore, the majority of children have habits driving the malocclusion. Mouth breathing, tongue thrusting and incorrect swallowing patterns are all known causes of malocclusion and poor facial growth. Aims: To evaluate the prevalence of dental feature that might result in malocclusion and need for early orthodontic treatment.Settings and Design: Groups of 532 school going children were selected and complete case history was taken and were categorized based on the type of malocclusions, dental features that can predetermine need for early orthodontic treatment. Statistical analysis used. Results: The results shows the increase in prevalence of malocclusion and the dental features that gives clues for an orthodontist to frame up his treatment modalities not just for corrective orthodontics but for also preventive and interceptive orthodontics. Conclusion: Angle's Class I malocclusion is most commonly seen malocclusion followed by class II division 1 malocclusion followed by Angles class II division 2 malocclusion. In angle's class I malocclusion, incidence of crowding is more followed by proclination of anterior teeth. There is no significant difference between incidence of malocclusion in males and females. The children who needed immediate orthodontic care were more than the children who doesn't need an orthodontic treatment. Need for increase of awareness programs is required in order to educate the people about the early orthodontic treatment.


Prabhakar R.,Thaimoogambigai Dental College | Karthikeyan,Thaimoogambigai Dental College | Sarvanan,Thaimoogambigai Dental College | Vikram R.,Thaimoogambigai Dental College | Abinaya,Thaimoogambigai Dental College
Journal of Clinical and Diagnostic Research | Year: 2014

Aims and Objectives: To evaluate and compare the shear bond strength of stainless steel brackets and ceramic brackets at 24h after etching the enamel with acidulated phosphate fluoride gel (1.23% APF) at different proportions (40%,30%,20%) incorporated in conventional etchant (37% phosphoric acid) Materials and Methods: Eighty premolars (maxillary and mandibular first and second premolars) extracted for orthodontic purpose has been selected for the study and samples were divided into 4 groups containing 10 teeth each. Comprised of teeth etched Group 1 with 40% of APF gel etchant is Group 2 teeth etched with 30% of APF gel in Group 3 teeth etched with 20% of APF gel etchant and Group 4 teeth were etched with conventional etchant (37% phosphoric acid) Results: The experimental group of Acidulated Phosphate Fluoride (APF) at different proportion (40%,30%,20%) incorporated with etchant application for 40s on the enamel surface at 24h indicated that group 4 showed the higher bond strength of all other remaining groups and the groups 1,2 and 3 showed satisfactory bond strength. The statistical evaluation also revealed that the bond strength of control group (37% phosphoric acid) was greater than those of experimental groups. The present study results shows that the ceramic brackets have higher bond strength than stainless steel brackets (material wise).


PubMed | Meenakshiammal Dental College, Sree Balaji Dental College and Thaimoogambigai Dental College
Type: Journal Article | Journal: Indian journal of dental research : official publication of Indian Society for Dental Research | Year: 2016

Obesity represents the systemic condition capable of influencing the onset and progression of periodontal disease. Obesity is associated with oxidative stress. Plasma level of reactive oxidative metabolites (ROMs) is measured as an indicator of oxidative stress in the body. The aim of this study is to assess and compare the plasma ROM levels in obese subjects with healthy and inflammatory periodontal status.Sixty subjects selected were grouped as 15 obese or overweight subjects with generalized chronic periodontitis, 15 obese or overweight subjects with generalized chronic gingivitis, 15 obese or overweight subjects with healthy periodontium, and 15 nonobese and healthy periodontium. The clinical periodontal parameters such as plaque index, gingival index, probing pocket depth, and clinical attachment level were measured. Blood samples were obtained to measure the plasma levels of ROM.In this study, obese subjects with chronic periodontitis (Group I) had mean plasma ROM levels (442.3 15.65 Carratelli unit [CARR U]) showing 100% subjects with high oxidative stress. Obese subjects with chronic gingivitis (Group II) had mean plasma ROM levels (358.7 20.61 CARR U) indicating 86.7% subjects with oxidative stress. Obese subjects with healthy periodontium (Group III) had 46.7% subjects with slight oxidative stress, and the mean ROM level was 320.2 17.57. Nonobese subjects with healthy periodontium (Group IV) had 80% of subjects with normal oxidative stress and the mean plasma ROM level was 296.9 20.35 CARR U. The intra- and inter-group comparison showed significant difference (P < 0.001). From our study, we report that obese subjects with periodontitis have more oxidative stress compared to obese subjects with healthy periodontium.


PubMed | Thaimoogambigai Dental College
Type: Journal Article | Journal: Journal of clinical and diagnostic research : JCDR | Year: 2014

With the advent of functional appliances and orthopedic appliances the elimination and correction of skeletal and dental discrepancies has been much reduced. Most orthodontists agree that elimination of oral habits and orthopaedic treatment of class 3 malocclusion and posterior cross bites deserve treatment at an early age. Early treatment was proposed along the lines of catch them in the young, and you see it, you treat it is the main ideology of Early Orthodonticc Treatment (EOT). Furthermore, the majority of children have habits driving the malocclusion. Mouth breathing, tongue thrusting and incorrect swallowing patterns are all known causes of malocclusion and poor facial growth.To evaluate the prevalence of dental feature that might result in malocclusion and need for early orthodontic treatment.Groups of 532 school going children were selected and complete case history was taken and were categorized based on the type of malocclusions, dental features that can predetermine need for early orthodontic treatment. Statistical analysis used.The results shows the increase in prevalence of malocclusion and the dental features that gives clues for an orthodontist to frame up his treatment modalities not just for corrective orthodontics but for also preventive and interceptive orthodontics.Angles Class I malocclusion is most commonly seen malocclusion followed by class II division 1 malocclusion followed by Angles class II division 2 malocclusion. In angles class I malocclusion, incidence of crowding is more followed by proclination of anterior teeth. There is no significant difference between incidence of malocclusion in males and females. The children who needed immediate orthodontic care were more than the children who doesnt need an orthodontic treatment. Need for increase of awareness programs is required in order to educate the people about the early orthodontic treatment.

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