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Vandana Shenoy K.,Thai Moogambigai Dental College | Ramesh K.V.,Kasturba Medical College
Journal of Oral and Maxillofacial Surgery | Year: 2014

Objectives: To evaluate the effects of topical hemocoagulase on intra-oral extraction sockets and impact on the healing process as well as to produce a clinico-histological healing score. Study Design: This prospective study compared two extraction sites in each subject. One site received topical hemocoagulase while other site did not receive it. Both the sites were chosen in the same patient and extraction was done at separate intervals. The biopsy was done on a randombasis with the pathologist being blinded to the study. Clinical evaluation was done on days 7, 14 and 21. Biopsy was done either on days 7 or 14 for the case as well as for the control. A clinical as well as histological score was developed and the healing was assessed. Statistical analysis was done using Wilcoxon signed rank test and p value ≤0.05 was considered significant and z-score was also calculated. Results: The clinical score did not show any statistical significance. The histological total score on day 14 and combined overall analysis of days 7 and 14 showed statistical significance. There was an increased incidence (n = 4) of osteoid formation in the hemocoagulase group on day 14. Conclusion: The application of hemocoagulase may improve and accelerates the process of wound healing in extraction sockets. © The Association of Oral and Maxillofacial Surgeons of India 2014. Source

Ahmed N.,Thai Moogambigai Dental College | Mony G.,SRM University | Parthasarthy H.,SRM University
Journal of Natural Science, Biology and Medicine | Year: 2014

External cervical resorption (ECR) is the loss of dental hard tissue as a result of odontoclastic action; it usually begins on the cervical region of the root surface of the teeth. The etiology, predisposing factors, diagnosis, and management of ECR have been reviewed here. Effective management and appropriate treatment can only be carried out if the true nature and exact location of the ECR lesion are known. This paper reports on the management of a case of external cervical root resorption (ECRR), which involved root canal treatment and removal of the resorbing area of the affected tooth as well as filling the resorbed area with mineral trioxide aggregate (MTA) and resin-modified glass ionomer filling material (RMGIC). The defect was filled with bone graft material and guided tissue regeneration (GTR) membrane. This case highlights the importance of using MTA and successful management of cervical resorption with a stable uneventful clinical recovery. Source

Arunachalam L.T.,Thai Moogambigai Dental College | Rao S.,Sri Ramachandra University
Indian Journal of Dental Research | Year: 2013

Background: Drug-induced gingival overgrowth (DIGO) is one of the unwanted side effects of amlodipine therapy, but the pathogenesis still remains unclear. Apoptosis, which plays a ubiquitous role in tissue homeostasis, including gingiva, may be involved in the development of gingival enlargement. Aims and Objectives: (i) To study the distribution of Bcl-2 in healthy and overgrown gingival tissues. (ii) To compare and correlate the Bcl-2 expression in gingival samples from subjects on amlodipine therapy to the findings in healthy controls. Materials and Methods: A total of 25 subjects were recruited for the study - 15 hypertensive patients and 10 systemically healthy subjects. Both the groups were analyzed for Bcl-2 expression using immunohistochemistry. Results: Few of the control specimens showed weak positivity to Bcl-2 antibody, with the distribution limited to the basal cell layers alone, whereas 10 hyperplastic specimens expressed Bcl-2 and, unlike the control group, the distribution pattern was seen in both basal and suprabasal layers. Conclusion: The results indicate that the pathogenesis of amlodipine-induced gingival overgrowth might involve inhibition of apoptosis, especially with morphogenesis of hyperplastic gingival epithelia. Source

Shankar Ram V.,Thai Moogambagi Dental College | Parthiban,Thai Moogambagi Dental College | Sudhakar U.,Thai Moogambagi Dental College | Mithradas N.,Thai Moogambagi Dental College | Prabhakar R.,Thai Moogambigai Dental College
Journal of Clinical and Diagnostic Research | Year: 2015

Periodontitis, is an inflammatory state of the tooth supporting structures and if left untreated, the disease continues to progressive bone destruction and subsequent tooth loss. The increasing prevelance of periodontal disease paved way to the development of new diagnostic tests that could detect the presence of active disease,the course of the disease and its response to treatment. Bone is a metabolically active tissue and undergo continuous remodelling, a process that largely relies on the activity of osteoclasts to remove bone and of osteoblasts to form bone. In health,bone resorption and formation are coupled to each other and its long term maintenance of skeletal balance is brought about by the systemic hormones and local mediators.In contrasts,during disease there is a pronounced in balance in bone turnover. Bone biomarkers which are produced either in health or in disease state are tell tale markers which would be used to monitor the health status. This review highlights, the recent advances in the use of biomarkers of bone remodelling,that could facilitate the screening, diagnosis and management of periodontal diseases. © 2015, Journal of Clinical and Diagnostic Research. All rights reserved. Source

Eswaran M.A.,Thai Moogambigai Dental College | Srividhya S.,Ragas Dental College and Hospital | Prabhu R.,Thai Moogambigai Dental College | Geetha K.R.,Thai Moogambigai Dental College
Journal of Clinical and Diagnostic Research | Year: 2014

Purpose of the Study: The present study was conducted to estimate the serum levels of Circulating Immune Complexes in patients with Oral Leukoplakia,Oral sub mucous fibrosis and normal subjects and correlate these values with the clinical grades of the diseases. Materials and Methods: The study consisted of 25 Oral Leukoplakia patients, 25 Oral sub mucous fibrosis patients and 25 Normal subjects. Results: The mean serum levels of CIC showed a gradual increase from normal subjects to Oral Leukoplakia patients and showed a high values in Oral sub mucous fibrosis patients. The mean serum levels of CIC also showed a gradual increase from clinical grade I to grade IV of Oral sub mucous fibrosis. Conclusion: Serum levels of CIC may be taken as a prognostic marker for disease progression of patients with Oral Leukoplakia and Oral sub mucous fibrosis. Source

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