Tung N.-T.,Hanoi University of Pharmacy |
Tran C.-S.,National Institute for Food Control |
Nguyen T.-L.,Hanoi University of Pharmacy |
Hoang T.,Hanoi University of Pharmacy |
And 2 more authors.
European Journal of Pharmaceutics and Biopharmaceutics | Year: 2017
The objective of this study was to prepare and evaluate some physiochemical and biopharmaceutical properties of bitter taste masking microparticles containing azithromycin loaded in dispersible tablets. In the first stage of the study, the bitter taste masking microparticles were prepared by solvent evaporation and spray drying method. When compared to the bitter threshold (32.43μg/ml) of azithromycin (AZI), the microparticles using AZI:Eudragit L100=1:4 and having a size distribution of 45-212μm did significantly mask the bitter taste of AZI. Fourier transform infrared spectroscopy (FTIR), and proton nuclear magnetic resonance spectroscopy (1H NMR) proved that the taste masking of microparticles resulted from the intermolecular interaction of the amine group in AZI and the carbonyl group in Eudragit L100. Differential scanning calorimeter (DSC) analysis was used to display the amorphous state of AZI in microparticles. Images obtaining from optical microscopy and scanning electron microscopy (SEM) indicated the existence of microparticles in regular cube shape with many layers. In the second stage, dispersible tablets containing microparticles (DTs-MP) were prepared by direct compression technique. Stability study was conducted to screen pH modulators for DTs-MP, and a combination of alkali agents (CaCO3:NaH2PO4, 2:1) was added into DTs-MP to create microenvironment pH of 5.0-6.0 for the tablets. The disintegration time of optimum DTs-MP was 53±5.29s and strongly depended on the kinds of lubricant and diluent. The pharmacokinetic study in the rabbit model using liquid chromatography tandem mass spectrometry showed that the mean relative bioavailability (AUC) and mean maximum concentration (Cmax) of DTs-MP were improved by 2.19 and 2.02 times, respectively, compared to the reference product (Zithromax®, Pfizer). © 2017 Elsevier B.V.
Hien T.T.,Lund University |
Ha D.T.,National Institute of Medicinal Materials |
Truong D.M.,Thai Nguyen University |
Duc L.V.,Hanoi University |
And 3 more authors.
Biomedical and Pharmacology Journal | Year: 2016
p53, a tumor suppressor protein, has important roles in DNA repair, cell cycle and apoptosis, is a one of the key events in cancer development. Coix lacryma-jobi seed has been used as a food and traditional medicine plant with anti-oxidant, anti-cancer and anti-diabetic effects. In currently research, we identified the most potent p53-increasing compound among 4 compounds (1-4) found in Coix lacryma-jobi and demonstrated its molecular mechanism in MCF-7 cells. Among the four isolated compounds (1-4), triolein most increased p53. Triolein treatment induced p53, p21, p27 and Bax in MCF-7 cells. Moreover, triolein caused S phase arrest through suppression of CDK1, phopho-Rb and E2F1 in dose-dependent manner. We also observed the decreasing of DNA synthesis by triolein. These data suggest that triolein may induced cell cycle restart involve DNA synthesis and apoptosis pathway in MCF-7 cells. © 2016, Oriental Scientific Publishing Company. All rights reserved.
Le D.-C.,University of Occupational and Environmental Health Japan |
Le D.-C.,Thai Binh Medical University |
Kubo T.,University of Occupational and Environmental Health Japan |
Fujino Y.,University of Occupational and Environmental Health Japan |
And 4 more authors.
Contraception | Year: 2012
Background: Ovarian cancer, one of the most common cancers in women and the most serious gynecologic cancer, is known to be influenced by reproductive factors, but these factors have not previously been examined in Vietnamese women. Study Design: We analyzed 262 ovarian cancer patients recruited from 27 hospitals in 12 provinces and Ha Noi City from April 2001 to May 2006, plus 755 controls matched by age and residential address. Results: The risk of ovarian cancer was significantly lower in parous women than nulliparous women. Use of an intrauterine contraceptive device was also associated with a reduced risk. In contrast, induced abortion, late menopause and years of ovulation were significantly associated with an increased risk of cancer. Conclusions: Parity and intrauterine device use were associated with a reduced risk of ovarian cancer in Vietnamese women, whereas induced abortion, late menopause and years of ovulation were associated with an increased risk. © 2012 Elsevier Inc.
Quyen B.T.L.,Thai Binh Medical University |
Mai D.N.,Institute of Physics |
Lan N.T.,Institute of Physics |
Viet N.A.,Institute of Physics
Journal of Physics: Conference Series | Year: 2015
It is well known that from four fundamental forces, only electro-magnetic force plays clear and important role in our life reality. The spin one exchange boson caring the electromagnetic interaction is photon. The condition of zero-mass of photon leads to the Coulomb law with long-range interaction behavior. We consider analogy Anderson-Higgs mechanism, in some liquid water environments at a certain temperature, photon can have a finite effective mass, consequence to a Yukawa type potential. This screening potential could leads to sort-range behavior of electro-magnetic effective interaction. We use this mechanism to develop physics models to explain some phenomena in life and soft systems. © Published under licence by IOP Publishing Ltd.
PubMed | Korea University, Vietnam Academy of Science and Technology, Wonkwang University, Thai Binh Medical University and 2 more.
Type: | Journal: Journal of Asian natural products research | Year: 2016
Inhibitory effects of NO production in RAW 264.7 macrophages guided the isolation of nine prenylated isoflavones, including a new cudraisoflavone L (1) and eight known metabolites furowanin B (2), erysubin A (3), wighteone (4), lupalbigenin (5), laburnetin (6), isolupalbigenin (7), 6,8-diprenylorobol (8), millewanin H (9) from the leaves of Cudrania tricuspidata. At the concentration of 10M, compounds 1, 2, and 4 significantly inhibited NO production with the inhibitory values of 72.52.4, 66.91.8, and 55.42.7%, respectively. In addition, all of isolated compounds 1-9 showed promising cytotoxic effects toward HL-60 cells (IC
Webber G.,University of Ottawa |
Spitzer D.,University of Ottawa |
Somrongthong R.,Chulalongkorn University |
Dat T.C.,Thai Binh Medical University |
Kounnavongsa S.,National University of Laos
Globalization and Health | Year: 2012
Background: The purpose of the research was to assess access to sexual and reproductive health services for migrant women who work as beer promoters. This mixed methods research was conducted in Phnom Penh, Cambodia, Bangkok, Thailand, Vientiane, Laos, and Hanoi, Vietnam during 2010 to 2011.Methods: Focus groups were held with beer promoters and separate focus groups or interviews with key informants to explore the factors affecting beer promoters' access to health care institutions for reproductive health care. The findings of the focus groups were used to develop a survey for beer promoters. This survey was conducted in popular health institutions for these women in each of the four Asian cities.Results: Several common themes were evident. Work demands prevented beer promoters from accessing health care. Institutional factors affecting care included cost, location, environmental factors (e.g. waiting times, cleanliness and confidentiality) and service factors (e.g. staff attitudes, clinic hours, and availability of medications). Personal factors affecting access were shyness and fear, lack of knowledge, and support from family and friends.The survey of the beer promoters confirmed that cost, location and both environmental and service factors impact on access to health care services for beer promoters. Many beer promoters are sexually active, and a significant proportion of those surveyed rely on sex work to supplement their income. Many also drink with their clients. Despite a few differences amongst the surveyed population, the findings were remarkably similar across the four research sites.Conclusions: Recommendations from the research include the provision of evening and weekend clinic hours to facilitate access, free or low cost clinics, and health insurance through employer or government plans which are easy to access for migrants. Other improvements that would facilitate the access of beer promoters to these services include increased funding to hire more staff (reducing waiting times) and to stock more needed medications, mobile clinics to come to the workplace or free transportation for beer promoters to the clinics, improved training to reduce health care provider stigma against beer promoters, and public education about the importance of reproductive health care, including preventative services. © 2012 Webber et al.; licensee BioMed Central Ltd.
Webber G.C.,University of Ottawa |
Spitzer D.L.,University of Ottawa |
Somrongthong R.,Chulalongkorn University |
Dat T.C.,Thai Binh Medical University |
Kounnavongsa S.,National University of Laos
Asia-Pacific Journal of Public Health | Year: 2015
Migrant beer promoters in Cambodia, Laos, Thailand, and Vietnam were surveyed to determine their experiences in accessing reproductive health care services in the cities of Phnom Penh, Vientiane, Bangkok, and Hanoi. A total of 7 health care institutions were chosen as popular with migrant beer promoters. Staff at these institutions provided information on the institution, and 390 beer promoters were surveyed about their experiences while accessing services. There were discrepancies between findings from the staff interviews and the experiences of the beer promoters. In general, the migrant women were satisfied with the cost, location, friendliness of the health care providers, and knowledge and skills of the providers. They were less positive about confidentiality and waiting times, though many still agreed that these were not an issue. Health care planners and providers should take note of the issues affecting access to reproductive health care services for migrant women when they design and implement services. © 2012 APJPH.
PubMed | Chulalongkorn University, National University of Laos, University of Ottawa and Thai Binh Medical University
Type: Journal Article | Journal: Asia-Pacific journal of public health | Year: 2015
Migrant beer promoters in Cambodia, Laos, Thailand, and Vietnam were surveyed to determine their experiences in accessing reproductive health care services in the cities of Phnom Penh, Vientiane, Bangkok, and Hanoi. A total of 7 health care institutions were chosen as popular with migrant beer promoters. Staff at these institutions provided information on the institution, and 390 beer promoters were surveyed about their experiences while accessing services. There were discrepancies between findings from the staff interviews and the experiences of the beer promoters. In general, the migrant women were satisfied with the cost, location, friendliness of the health care providers, and knowledge and skills of the providers. They were less positive about confidentiality and waiting times, though many still agreed that these were not an issue. Health care planners and providers should take note of the issues affecting access to reproductive health care services for migrant women when they design and implement services.
Vu M.Q.,Institute of Biodiversity and Ecosystem Research IBER |
Vu M.Q.,Hanoi National University of Education |
Nguyen T.H.,Thai Binh Medical University |
Vu L.V.,Vietnam National Museum of Nature
Acta Zoologica Bulgarica | Year: 2014
A review of the oribatid mites of the genus Papillacarus Kunst, 1959 (Oribatida: Lohhmanniidae) in Vietnam, with remarks on the taxonomic status of P. arboriseta, is presented. The article provides also a key to nine species recorded in Vietnam, namely P. arboriseta Jeleva et Vu, 1987, P. benenensis Vu, Ermilov et Dao, 2010, P. cornutus (Sarkar et Subias, 1984), P. hirsutus (Aoki, 1961), P. indistinctus Ermilov, Anichkin et Wu, 2012, P. polygonatus Ermilov et Anichkin, 2011, P. polysetosus Ermilov, Anichkin et Wu, 2012, P. ramosus Balogh, 1961, and P. undirostratus Aoki, 1965. For each species, a list of synonyms, information on types and type localities, a brief new description, an illustration, taxonomic problems, as well as remarks on the ecology and distribution are included. These species are known from the Oriental Region and Southeast Asia, and five of them are recorded only from Vietnam. © 2014 Institute of Biodiversity and Ecosystem Research - BAS.
PubMed | Osaka University, Thai Binh Medical University and Osaka Prefectural Institute of Public Health
Type: Journal Article | Journal: Tropical animal health and production | Year: 2016
Reports of livestock infections with extended-spectrum beta-lactamase-producing Escherichia coli (ESBL-E) are increasing. Based on interviews conducted over a 6-month period, we found that veterinarians in the Vietnamese province of Thai Binh prefer to prescribe colistin-based drugs (CBD) in chicken farms. We aimed to clarify whether CBD use selects for strains of colistin-resistant ESBL-E. With the cooperation of seven local households, we detected ESBL-E in chickens feces after treating chickens with CBD. Phylogenetic groupings and the presence of CTX-M/AmpC genes were determined, and the multi-antibiotic susceptibility of isolates was analyzed. Our results showed that ESBL-E presented in seven chickens feces from two households. Seventy-two percent of ESBL-E isolates harbored CTX-M9 and the phylogenetic group A; the colistin minimum inhibitory concentration (MIC) of all isolated ESBL-E ranged from 0.064 to 1gmL