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Flagstaff, AZ, United States

Trueba G.,San Francisco de Quito University | Garces V.,San Francisco de Quito University | Barragan V V.,San Francisco de Quito University | Colman R.E.,TGEN North | And 3 more authors.
Vector-Borne and Zoonotic Diseases | Year: 2013

Escherichia coli O157:H7 is frequently isolated from cases of diarrhea in many industrialized countries; however, it is seldom found in developing countries. The present manuscript reports the presence of E. coli O157:H7 in Ecuadorian livestock, a country where enterohemorrhagic E. coli disease in humans has never been reported. The Ecuadorian isolates were genetically related to some strains linked to clinical cases in the United States as assessed by multiple-locus variable number tandem repeat (VNTR) analysis. © 2013, Mary Ann Liebert, Inc. Source


Muller E.E.L.,University of Luxembourg | Pinel N.,University of Luxembourg | Pinel N.,Institute for Systems Biology | Laczny C.C.,University of Luxembourg | And 21 more authors.
Nature Communications | Year: 2014

Microbial communities are complex and dynamic systems that are primarily structured according to their members' ecological niches. To investigate how niche breadth (generalist versus specialist lifestyle strategies) relates to ecological success, we develop and apply an integrative workflow for the multi-omic analysis of oleaginous mixed microbial communities from a biological wastewater treatment plant. Time- and space-resolved coupled metabolomic and taxonomic analyses demonstrate that the community-wide lipid accumulation phenotype is associated with the dominance of the generalist bacterium Candidatus Microthrix spp. By integrating population-level genomic reconstructions (reflecting fundamental niches) with transcriptomic and proteomic data (realised niches), we identify finely tuned gene expression governing resource usage by Candidatus Microthrix parvicella over time. Moreover, our results indicate that the fluctuating environmental conditions constrain the accumulation of genetic variation in Candidatus Microthrix parvicella likely due to fitness trade-offs. Based on our observations, niche breadth has to be considered as an important factor for understanding the evolutionary processes governing (microbial) population sizes and structures in situ. © 2014 Macmillan Publishers Limited. All rights reserved. Source

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