Osaka, Japan

Tezukayama Gakuin University is a private university with campuses in the cities of Ōsakasayama and Sakai in Osaka Prefecture, Japan. The predecessor of the school was founded in 1916, and it was chartered as a junior women's college in 1950. In 2007 the school became coeducational. Wikipedia.


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Kurashina T.,Jichi Medical University | Nagasaka S.,Jichi Medical University | Watanabe N.,Yodogawa Christian Hospital | Yabe D.,Kansai Electric Power Co. | And 8 more authors.
Journal of Atherosclerosis and Thrombosis | Year: 2014

Aim: Chronic kidney disease (CKD) is associated with cardiovascular events. Tumor necrosis factor (TNF) and/or its receptors have been postulated to be involved in renal pathophysiology. It is unclear whether an increased TNF system activity is present before the development of apparent CKD. Methods: Four hundred and twenty non-diabetic Japanese subjects with an estimated GFR (eGFR) greater than 60 ml/min/1.73 m2 were recruited for measurement of the HbA1c, insulin, TNF system activity (TNF-α, soluble TNF receptor 1 (sTNF-R1) and sTNF-R2) levels and various parameters, including the lipid, high-sensitivity C-reactive protein (hsCRP), high-molecular-weight (HMW) adiponectin and leptin levels. The subjects were stratified according to the eGFR: the G1 level (eGFR ≥90 ml/min/1.73 m2) and the G2 level (90


Realini E.,Kyoto University | Yoshida D.,Tezukayama Gakuin University | Reguzzoni M.,Polytechnic of Milan | Raghavan V.,Osaka City University
Applied Geomatics | Year: 2012

Providing enhanced satellite positioning as a web service can be an effective way to enable low-level GPS receivers to perform surveys with a good accuracy and to reduce hardware cost, by removing computation capability and embedded proprietary software. goGPS is an open source application for achieving sub-meter accuracy with low-cost GPS receivers by exploiting real-time kinematic positioning, Kalman filtering, aid from a digital terrain model, and in general by integrating GPS data with other sources of information. Since goGPS directly processes raw GPS observations, it provides a means to substitute blackbox processing components (e.g., GPS chipsets) with open source positioning software. goGPS can work either in realtime or post-processing, by acquiring raw GPS data in input and providing positioning (i.e., coordinates) in output. Though originally developed in MATLAB, goGPS was recently ported to Java in order to have the possibility to provide it as a web service, thus allowing a wider user base to develop and use it. Since real-time GPS positioning heavily relies on fast matrix computation, a careful selection of Java matrix libraries was carried out in order to obtain optimal performances. An Open Geospatial Consortium standard Web Processing Service (WPS) implementation of goGPS by means of ZOO WPS framework was developed and tested in order to let lightweight clients just acquire raw GPS data, send them to a server for processing, and receive back the accurate positioning. © Società Italiana di Fotogrammetria e Topografia (SIFET) 2012.


PubMed | Osaka Prefecture University, Iwate University, Towa Corporation and Tezukayama Gakuin University
Type: Journal Article | Journal: Andrologia | Year: 2016

Although Lepidium meyenii (maca), a plant growing in Perus central Andes, has been traditionally used for enhancing fertility and reproductive performance in domestic animals and human beings, effects of maca on reproductive organs are still unclear. This study examined whether feeding the hydroalcoholic extract powder of maca for 6 weeks affects weight of the reproductive organs, serum concentrations of testosterone and luteinising hormone (LH), number and cytoplasmic area of immunohistochemically stained Leydig cells, and steroidogenesis of cultured Leydig cells in 8-week-old male rats. Feeding the extract powder increased weight of seminal vesicles, serum testosterone level and cytoplasmic area of Leydig cells when compared with controls. Weight of prostate gland, serum LH concentration and number of Leydig cells were not affected by the maca treatment. The testosterone production by Leydig cells significantly increased when cultured with 22R-hydroxycholesterol or pregnenolone and tended to increase when cultured with hCG by feeding the extract powder. The results show that feeding the hydroalcoholic extract powder of maca for 6 weeks increases serum testosterone concentration associated with seminal vesicle stimulation in male rats, and this increase in testosterone level may be related to the enhanced ability of testosterone production by Leydig cells especially in the metabolic process following cholesterol.


Yoshida D.,Tezukayama Gakuin University | Song X.,University of Chinese Academy of Sciences | Raghavan V.,Osaka City University
Applied Geomatics | Year: 2010

Recent advanced performance of low-cost Global Positioning System (GPS) and GPS-enabled cell phones has contributed a great deal to the development of locationaware services and systems. High-speed broadband technology has promoted collaborative projects such as OpenStreetMap or other User Generated Contents services. In this research, a Web-based prototype system for GPS track log and point of interest (POI) management was developed to archive a collaborative framework in field surveys. The main function of the system can be separated into three parts: data collection, data management, and data quality enhancement. The system supports real-time data collection for the future ubiquitous environment and also can monitor real-time GPS positions. This research shows functionalities that can minimize GPS errors using Dilution of Precision filtering and data quality enhancing techniques using the Douglas-Peucker algorithm and PgRouting. The research introduces a system that provides an interoperable framework in which to work with other geospatial services through open geospatial standards. © The Author(s) 2010.


Kamisako T.,Kinki University | Tanaka Y.,Kinki University | Ikeda T.,Tezukayama Gakuin University | Yamamoto K.,Kinki University | Ogawa H.,Tezukayama Gakuin University
Hepatology Research | Year: 2012

Aim: Fish oil rich in n-3 polyunsaturated fatty acids is known to affect hepatic lipid metabolism. Several studies have demonstrated that fish oil may affect the bile acid metabolism as well as lipid metabolism, whereas only scarce data are available. The aim of this study was to investigate the effect of fish oil on the gene expression of the transporters and enzymes related to bile acid as well as lipid metabolism in the liver and small intestine. Methods: Seven-week old male C57BL/6 mice were fed diets enriched in 10% soybean oil or 10% fish oil for 4 weeks. After 4 weeks, blood, liver and small intestine were obtained. Results: Hepatic mRNA expression of lipids (Abcg5/8, multidrug resistance gene product 2) and bile acids transporters (bile salt export pump, multidrug resistance associated protein 2 and 3, organic solute transporter α) was induced in fish oil-fed mice. Hepatic Cyp8b1, Cyp27a1 and bile acid CoA:amino acid N-acyltransferase were increased in fish oil-fed mice compared with soybean-oil fed mice. Besides, intestinal cholesterol (Abcg5/8) and bile acid transporters (multidrug resistance associated protein 2 and organic solute transporter α) were induced in fish oil-fed mice. Conclusion: Fish oil induced the expression of cholesterol and bile acid transporters not only in liver but in intestine. The upregulation of Abcg5/g8 by fish oil is caused by an increase in cellular 27-HOC through Cyp27a1 induction. The hepatic induction of bile acid synthesis through Cyp27a1 may upregulate expression of bile acid transporters in both organs. © 2012 The Japan Society of Hepatology.


Tanaka Y.,Kinki University | Ikeda T.,Tezukayama Gakuin University | Yamamoto K.,Kinki University | Ogawa H.,Tezukayama Gakuin University | Kamisako T.,Kinki University
Journal of Gastroenterology and Hepatology (Australia) | Year: 2012

Background and Aim: Hepatic excessive iron may play a role in the pathogenesis of non-alcoholic steatohepatitis (NASH). Nrf2 is a master regulator of antioxidative responses. However, the role of Nrf2 in lipid and iron homeostasis remains unclear. Accordingly, it was examined how Nrf2 regulates lipid-related and iron-regulatory genes after feeding a high-fat diet (HFD) with iron. Methods: Wild-type and Nrf2-null mice were fed the following diets: (i) control diet (4% soybean oil) for 12weeks, (ii) control diet for 8weeks followed by control diet containing 0.5% carbonyl iron for 4weeks, (iii) HFD (4% soybean oil and 16% lard) for 12weeks, (iv) HFD for 8weeks followed by HFD containing 0.5% carbonyl iron for 4weeks. Blood and livers were removed after 12weeks. Results: Nrf2-null control mice exhibited a tendency towards higher hepatic triglycerides compared to wild-type control mice. Hepatic malondialdehyde was higher and hepatic iron levels tended to be higher in Nrf2-null mice than wild-type counterparts while on a HFD. The HFD with iron synergistically induced mRNA expression of Pparα targets, including Acox and Cpt1 in wild-type mice, yet the induction was diminished in Nrf2-null mice. Hepatic hepcidin and ferroportin 1 mRNA expression were increased in wild-type mice after feeding a HFD with iron, but were unchanged in any group of Nrf2-null mice. Conclusions: Nrf2 deletion dysregulates hepatic mRNA expression of β-oxidation enzymes and iron-related genes, possibly causing a trend for increased hepatic triglyceride and iron concentrations. Nrf2 may have roles in the progression of NASH. © 2012 Journal of Gastroenterology and Hepatology Foundation and Wiley Publishing Asia Pty Ltd.


Kishino Y.,Kinki University | Kishino Y.,Osaka University | Tanaka Y.,Kinki University | Ikeda T.,Tezukayama Gakuin University | And 4 more authors.
Journal of Pharmacology and Experimental Therapeutics | Year: 2013

Accumulating evidence suggests that ezetimibe may be a promising agent for treatment of nonalcoholic fatty liver disease and steatohepatitis (NAFLD/NASH). Phlebotomy and dietary iron restriction reduce serum transaminase in NAFLD/NASH patients. Recent studies have shown that a mutual effect exists between lipid metabolism and iron metabolism. Accordingly, we examined the effect of ezetimibe on iron metabolism in mice fed a high-fat diet with or without iron. We fed C57BL/6 mice the following diets for 12 weeks. Experiment 1 comprised [1] a control diet (C), [2] C plus ezetimibe (0.3mg/day; 4 weeks) (CE), [3] a high-fat diet (H), and [4] H plus ezetimibe (HE). Experiment 2 comprised [1] C containing carbonyl iron (average; 22.4 mg/day; 6 weeks) (CI), [2] CI plus ezetimibe (CIE), [3] H containing carbonyl iron (HI), and [4] HI plus ezetimibe (HIE). Blood, livers, and duodenum were removed after 12 weeks. In experiment 1, the hepatic iron levels were higher in HE than H, whereas there was no difference between C and CE. Hepatic mRNA expression of transferrin receptor 1 and 2, ferritins, and hepcidin were increased more in CE than C, and more in HE than H. In the duodenum, divalent metal transporter 1, ferritin H, and hephaestin mRNA levels were increased in CE compared with C. In experiment 2, hepatic iron concentrations were higher in HIE than HI. Hepatic mRNA expression of ferritin L and hepcidin were increased in HIE compared with HI. In duodenum, ferritin L mRNA was increased in HIE compared with CIE. Ezetimibe induced hepatic iron uptake transporter expression in mice fed a high-fat diet, causing increased hepatic iron concentrations. Copyright © 2013 by The American Society for Pharmacology and Experimental Therapeutics.


PubMed | Tezukayama Gakuin University and Kwansei Gakuin University
Type: | Journal: Frontiers in neuroscience | Year: 2016

In order to examine the encoding of partial silence included in a sound stimulus in neural representation, time flow of the sound representations was investigated using mismatch negativity (MMN), an ERP component that reflects neural representation in auditory sensory memory. Previous work suggested that time flow of auditory stimuli is compressed in neural representations. The stimuli used were a full-stimulus of 170 ms duration, an early-gap stimulus with silence for a 20-50 ms segment (i.e., an omitted segment), and a late-gap stimulus with an omitted segment of 110-140 ms. Peak MMNm latencies from oddball sequences of these stimuli, with a 500 ms SOA, did not reflect time point of the physical gap, suggesting that temporal information can be compressed in sensory memory. However, it was not clear whether the whole stimulus duration or only the omitted segment duration is compressed. Thus, stimuli were used in which the gap was replaced by a tone segment with a 1/4 sound pressure level (filled), as well as the gap stimuli. Combinations of full-stimuli and one of four gapped or filled stimuli (i.e., early gap, late gap, early filled, and late filled) were presented in an oddball sequence (85 vs. 15%). If compression occurs only for the gap duration, MMN latency for filled stimuli should show a different pattern from those for gap stimuli. MMN latencies for the filled conditions showed the same pattern as those for the gap conditions, indicating that the whole stimulus duration rather than only gap duration is compressed in sensory memory neural representation. These results suggest that temporal aspects of silence are encoded in the same manner as physical sound.


Togami Y.,Tezukayama Gakuin University
IEEJ Transactions on Fundamentals and Materials | Year: 2015

Since the magnetic field of spherical symmetry does not exist in nature, it is understood that the electromagnetic field of spherical symmetry does not exist, either. This paper examines the electromagnetic field of the spherical symmetry which is produced by periodically changing the electric charge. It was found that the electromagnetic field of spherical symmetry was represented by a scalar potential of the spherical wave. It was also found that the scalar potential forms standing wave of spherical symmetry. © 2015 The Institute of Electrical Engineers of Japan.


PubMed | Tezukayama Gakuin University
Type: Journal Article | Journal: Journal of clinical biochemistry and nutrition | Year: 2016

Okara, a food by-product from the production of tofu and soy milk, is rich in three beneficial components: insoluble dietary fiber, -conglycinin, and isoflavones. Although isoflavones and -conglycinin have recently been shown to improve glucose tolerance, the effects of okara have not yet been elucidated. Therefore, we herein investigated the effects of okara on glucose tolerance in Goto-Kakizaki (GK) rats, a representative animal model of Japanese type 2 diabetes. Male GK rats were fed a 10% lard diet with or without 5% dry okara powder for 2 weeks and an oral glucose tolerance test was performed. Rats were then fed each diet for another week and sacrificed. The expression of genes that are the master regulators of glucose metabolism in adipose tissue was subsequently examined. No significant differences were observed in body weight gain or food intake between the two groups of GK rats. In the oral glucose tolerance test, increases in plasma glucose levels were suppressed by the okara diet. The mRNA expression levels of PPAR, adiponectin, and GLUT4, which up-regulate the effects of insulin, were increased in epididymal adipose tissue by the okara diet. These results suggest that okara provides a useful means for treating type 2 diabetes.

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