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Houston, TX, United States

Texas Southern University is a historically black university located in Houston, Texas, accredited by the Southern Association of Colleges and Schools.The University was established in 1927 as the Houston Colored Junior College. It developed through its private college phase as the four-year Houston Colored College. On March 3, 1947, the state declared this to be the first state university in Houston; it was renamed Texas State University for Negroes. In 1951, the name changed to Texas Southern University.Texas Southern University is one of the largest and most comprehensive HBCU in the nation. TSU is one of only four independent public universities in Texas and the only HBCU in Texas recognized as one of America's Top Colleges by Forbes magazine. TSU is the leading producer of college degrees to African Americans and Hispanics in Texas and ranks fourth in the nation in doctoral and professional degrees conferred to African Americans. The University is a member-school of the Thurgood Marshall College Fund. Wikipedia.

Cheung L.K.,Texas Southern University
Pharmacotherapy | Year: 2013

Age-related macular degeneration (AMD) is the leading cause of blindness in the elderly, and the prevalence of the disease increases exponentially with every decade after age 50 years. It is a multifactorial disease involving a complex interplay of genetic, environmental, metabolic, and functional factors. Besides smoking, hypertension, obesity, and certain dietary habits, a growing body of evidence indicates that inflammation and the immune system may play a key role in the development of the disease. AMD may progress from the early form to the intermediate form and then to the advanced form, where two subtypes exist: the nonneovascular (dry) type and the neovascular (wet) type. The results from the Age-Related Eye Disease Study have shown that for the nonneovascular type of AMD, supplementation with high-dose antioxidants (vitamin C, vitamin E, and β-carotene) and zinc is recommended for those with the intermediate form of AMD in one or both eyes or with advanced AMD or vision loss due to AMD in one eye. As for the neovascular type of the advanced AMD, the current standard of therapy is intravitreal injections of vascular endothelial growth factor inhibitors. In addition, lifestyle and dietary modifications including improved physical activity, reduced daily sodium intake, and reduced intake of solid fats, added sugars, cholesterol, and refined grain foods are recommended. To date, no study has demonstrated that AMD can be cured or effectively prevented. Clearly, more research is needed to fully understand the pathophysiology as well as to develop prevention and treatment strategies for this devastating disease. © 2013 Pharmacotherapy Publications, Inc. Source

Xie H.,Texas Southern University
International journal of nanomedicine | Year: 2011

Gold nanoshells (NSs) have already shown great promise as photothermal actuators for cancer therapy. Integrin αvβ3 is a marker that is specifically and preferentially overexpressed on multiple tumor types and on angiogenic tumor neovasculature. Active targeting of NSs to integrin αvβ3 offers the potential to increase accumulation preferentially in tumors and thereby enhance therapy efficacy. Enzyme-linked immunosorbent assay (ELISA) and cell binding assay were used to study the in vitro binding affinities of the targeted nanoconjugate NS-RGDfK. In vivo biodistribution and tumor specificity were analyzed using 64Cu-radiolabeled untargeted and targeted NSs in live nude rats bearing head and neck squamous cell carcinoma (HNSCC) xenografts. The potential thermal therapy applications of NS-RGDfK were evaluated by subablative thermal therapy of tumor xenografts using untargeted and targeted NSs. ELISA and cell binding assay confirmed the binding affinity of NS-RGDfK to integrin αvβ3. Positron emission tomography/computed tomography imaging suggested that tumor targeting is improved by conjugation of NSs to cyclo(RGDfK) and peaks at ~20 hours postinjection. In the subablative thermal therapy study, greater biological effectiveness of targeted NSs was implied by the greater degree of tumor necrosis. The results presented in this paper set the stage for the advancement of integrin αvβ3-targeted NSs as therapeutic nanoconstructs for effective cancer therapy. Source

Shishodia S.,Texas Southern University
BioFactors | Year: 2013

Curcumin derived from the tropical plant Curcuma longa has a long history of use as a dietary agent, food preservative, and in traditional Asian medicine. It has been used for centuries to treat biliary disorders, anorexia, cough, diabetic wounds, hepatic disorders, rheumatism, and sinusitis. The preventive and therapeutic properties of curcumin are associated with its antioxidant, anti-inflammatory, and anticancer properties. Extensive research over several decades has attempted to identify the molecular mechanisms of curcumin action. Curcumin modulates numerous molecular targets by altering their gene expression, signaling pathways, or through direct interaction. Curcumin regulates the expression of inflammatory cytokines (e.g., TNF, IL-1), growth factors (e.g., VEGF, EGF, FGF), growth factor receptors (e.g., EGFR, HER-2, AR), enzymes (e.g., COX-2, LOX, MMP9, MAPK, mTOR, Akt), adhesion molecules (e.g., ELAM-1, ICAM-1, VCAM-1), apoptosis related proteins (e.g., Bcl-2, caspases, DR, Fas), and cell cycle proteins (e.g., cyclin D1). Curcumin modulates the activity of several transcription factors (e.g., NF-κB, AP-1, STAT) and their signaling pathways. Based on its ability to affect multiple targets, curcumin has the potential for the prevention and treatment of various diseases including cancers, arthritis, allergies, atherosclerosis, aging, neurodegenerative disease, hepatic disorders, obesity, diabetes, psoriasis, and autoimmune diseases. This review summarizes the molecular mechanisms of modulation of gene expression by curcumin. © 2012 International Union of Biochemistry and Molecular Biology, Inc. Source

Oyekan A.,Texas Southern University
Clinical and Experimental Hypertension | Year: 2011

Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors belonging to the nuclear receptor superfamily that undergo transactivation or transrepression by distinct mechanisms leading to induction or repression of expression of target genes. The PPAR family consists of three isoforms, α, γ, and ß/δ, which share similar structural organization, possess distinct functions, and vary in their ligand affinity, expression, and activity in different metabolic pathways in different tissues. PPARs are involved in many functions especially those involved in the regulation of vascular tone, inflammation and energy homeostasis and therefore represent important targets for hypertension, obesity, obesity-induced inflammation, and metabolic syndrome in general. PPARs may influence the inflammatory response either by direct transcriptional downregulation of proinflammatory genes via mechanisms involving transrepression, or indirectly via their transcriptional effects on lipid metabolism. On account of their pleiotropic effects, they are now known to be active participants in many disease conditions and they represent potent targets for the development of therapy of a wide array of diseases. © 2011 Informa Healthcare USA, Inc. Source

Agency: NSF | Branch: Standard Grant | Program: | Phase: HIST BLACK COLLEGES AND UNIV | Award Amount: 200.00K | Year: 2014

Research Initiation Awards provide support for junior and mid-career faculty at Historically Black Colleges and Universities who are building new research programs or redirecting and rebuilding existing research programs. It is expected that the award helps to further the faculty members research capability and effectiveness, improves research and teaching at his home institution, and involves undergraduate students in research experiences. The project at Texas Southern University has potential broader impact in a number of areas. The goal of the project is to develop a comprehensive understanding of the landscape factors on mercury loading and distribution in the East Tennessee watersheds of the Oak Ridge Reservation. This project will also enhance the research experience and training of undergraduate and graduate students at Texas Southern University.

The three specific objectives of the project include: characterizing the spatial and temporal trends of mercury bioaccumulation in watersheds; identifying and analyzing the influence of land use and land cover changes on the mercury dynamics in the watersheds; and investigating the fate and transport of mercury across the landscape. The first objective will be achieved by acquiring, assembling and interpreting both the spatial and long-term analytical data of all the sample media of the watersheds that drain the Oak Ridge reservation. Spatial and temporal analysis of the data will be conducted to identify the mercury concentration and bioaccumulation trends. The second objective will be achieved by quantifying the land use and land cover changes using time series aerial and satellite imagery. Quantitative relationships between the changes in landscape factors to mercury bioaccumulation will be established. The third objective will be achieved by superimposing and analyzing the hydrologic flow paths with watershed delineations, soil and sediment erosion rates, wetlands and other landscape factors with the available long term mercury analytical data.

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