Watertown, MA, United States

Tetraphase Pharmaceuticals

tphase.com
Watertown, MA, United States

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Patent
Tetraphase Pharmaceuticals | Date: 2016-03-24

The present invention is directed to a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof. The variables for Structural Formula I are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula I and its therapeutic use.


Patent
Tetraphase Pharmaceuticals | Date: 2016-05-25

The present invention is directed to a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof. The variables for Structural Formula (I) are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula (I) and its therapeutic use.


Sutcliffe J.A.,Tetraphase Pharmaceuticals
Annals of the New York Academy of Sciences | Year: 2011

The resolution of antibiotic-ribosomal subunit complexes and antibacterial-protein complexes at the atomic level has provided new insights into modifications of clinically relevant antimicrobials and provided new classes that target the protein cellular apparatus. New chemistry platforms that use fragment-based drug design or allow novel modifications in known structural classes are being used to design new antibiotics that overcome known resistance mechanisms and extend spectrum and potency by circumventing ubiquitous efflux pumps. This review provides details on seven antibiotics in development for treatment of moderate-to-severe community-acquired bacterial pneumonia and/or acute bacterial skin and skin structure infections: solithromycin, cethromycin, omadacycline, CEM-102, GSK1322322, radezolid, and tedizolid. Two antibiotics of the oxazolidinone class, PF-02341272 and AZD5847, are being developed as antituberculosis agents. Only three antibiotics that target the protein cellular machinery, TP-434, GSK2251052, and plazomicin, have a spectrum that encompasses multidrug-resistant Gram-negative pathogens. These compounds provide hope for treating key pathogens that cause serious disease in both the community and the hospital. © 2011 New York Academy of Sciences.


Patent
Tetraphase Pharmaceuticals | Date: 2012-12-18

The present invention is directed to a compound represented by Structural Formula (A): or a pharmaceutically acceptable salt thereof. The variables for Structural Formula (A) are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula (A) and its therapeutic use.


Patent
Tetraphase Pharmaceuticals | Date: 2013-08-30

The present invention is directed to a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof. The variables for Structural Formula (I) are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula (I), or a pharmaceutically acceptable salt thereof, and its therapeutic use.


Patent
Tetraphase Pharmaceuticals | Date: 2016-03-30

The present invention is directed to a compound represented by Structural Formula (A):


Patent
Tetraphase Pharmaceuticals | Date: 2014-11-04

The present invention is directed to a compound represented by Structural Formula (A): or a pharmaceutically acceptable salt thereof. The variables for Structural Formula (A) are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula (A) and its therapeutic use.


Patent
Tetraphase Pharmaceuticals | Date: 2014-01-08

The present invention is directed to a compound falling under Structural Formula (A):


Patent
Tetraphase Pharmaceuticals | Date: 2012-08-09

The present invention is directed to a compound represented by Structural Formula (A): or a pharmaceutically acceptable salt thereof. The variables for Structural Formula (A) are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula (A) and its therapeutic use.


Patent
Tetraphase Pharmaceuticals | Date: 2012-12-31

The present invention is directed to a compound represented by Structural Formula (I):

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