Testing Laboratory of Biological Activity and Toxicological Safety

Moscow, Russia

Testing Laboratory of Biological Activity and Toxicological Safety

Moscow, Russia
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Pligina K.L.,Testing Laboratory of Biological Activity and Toxicological Safety | Rodina I.A.,Testing Laboratory of Biological Activity and Toxicological Safety | Shevchenko T.V.,Testing Laboratory of Biological Activity and Toxicological Safety | Bekchanova E.S.,Testing Laboratory of Biological Activity and Toxicological Safety | And 2 more authors.
Bulletin of Experimental Biology and Medicine | Year: 2012

We studied DNA-damaging effects of dental bleaching systems containing hydrogen peroxide and/or carbamide peroxide by the "comet assay" (alkaline version). Dental bleaching systems in a hydrogen peroxide concentration range from 0.03 to 30 mM produced a genotoxic effect on isolated HeLa cells in vitro comparable with the effects of pharmacopoeial hydrogen peroxide or urea peroxide. Catalase protected the cells against products containing hydrogen peroxide and had no effect on the genotoxicity of samples containing carbamide peroxide. © 2012 Springer Science+Business Media, Inc.


PubMed | Testing Laboratory of Biological Activity and Toxicological Safety
Type: Journal Article | Journal: Bulletin of experimental biology and medicine | Year: 2012

We studied DNA-damaging effects of dental bleaching systems containing hydrogen peroxide and/or carbamide peroxide by the comet assay (alkaline version). Dental bleaching systems in a hydrogen peroxide concentration range from 0.03 to 30 mM produced a genotoxic effect on isolated HeLa cells in vitro comparable with the effects of pharmacopoeial hydrogen peroxide or urea peroxide. Catalase protected the cells against products containing hydrogen peroxide and had no effect on the genotoxicity of samples containing carbamide peroxide.

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