Terumo BCT Inc.

Lakewood, Colorado, United States

Terumo BCT Inc.

Lakewood, Colorado, United States
SEARCH FILTERS
Time filter
Source Type

Patent
Terumo BCT Inc. | Date: 2017-02-01

Embodiments described herein generally relate to passively replacing media in a closed cell expansion system to reduce or prevent the dilution of chemical signaling used to inhibit signaling pathways that keep a cell population in the lag phase of cell growth. To prevent such dilution, active inlet fluid flow to the system may be halted. To replace fluid lost by the system, a bag containing media may be attached to the waste line in replacement of the waste or outlet bag connected thereto. By turning off one or more pumps, media from the replacement bag is added to the system at the rate of evaporation. Chemical signaling dilution may be prevented while conserving system resources. Enhancement of chemical signaling to reduce the lag phase of cell growth may further be accomplished by adding molecules, such as chemical-signaling proteins, from a direct source to the system.


Patent
Terumo BCT Inc. | Date: 2017-08-02

Embodiments described herein generally provide for the scheduled feeding of cells in a cell expansion system. A schedule to proactively and automatically increase and/or maintain inlet rates of media to feed cells may be created, in which inlet rates to the intracapillary portion (or extracapillary portion) of a bioreactor may be increased or maintained according to the schedule. Such schedule may be conservative or aggressive or a combination thereof, for example. Multiple schedules may be used. Scheduled media exchanges may also be included. By following a feed schedule, the monitoring of metabolite levels may be optional. Inlet rates may be increased or maintained without manual manipulation. Media usage may also be more predictable. In an embodiment, a custom task(s) may be created to follow a desired feed schedule. In another embodiment, a pre-programmed task(s) may be used for the scheduled feeding of cells.


Patent
Terumo BCT Inc. | Date: 2017-04-12

The application discloses: a) two-wall and four-wall container for lyophilizing, storing, and transfusing a blood component comprising a wall made from a porous polymer permeable to water vapor and resistant to liquid water; b) methods of lyophilising biological material including pre-evaporation step or step of killing bacteria with photosensitizer and light; c) a system (apparatus) for use in lyophilising biological material comprising two plates and the system of increasing or decreasing the space between them and d) a method of preparing blood component for lyophilisation including pre-evaporation and optionally disinfection.


Patent
Terumo BCT Inc. | Date: 2017-02-01

Embodiments are described for receiving first data related to an amount of a first component in a multi-component liquid. A gain may be determined based on the first data. The multi-component liquid may be separated into at least two components. The gain may then be used to control a position of an interface between two separated components of the multi-component liquid, such as by using the gain in changing a speed of a pump pumping at least one of the components.


Patent
Terumo BCT Inc. | Date: 2017-06-21

Embodiments relate to systems, chambers, and methods for processing particles by washing, concentrating, and/or treating the particles. Some embodiments provide for the processing of cells that may be in a liquid medium (e.g., a liquid in which the cells were grown) and are processed by being washed and concentrated for later use in research or other therapies.


Patent
Terumo BCT Inc. | Date: 2016-05-12

Embodiments are described that relate to methods and systems for growing cells in a hollow fiber bioreactor. In embodiments, the cells may be exposed to an activator for activating expansion of the cells. The cells may in embodiments include T cells, and the activator may be in different forms, including, for example, antigen presenting cells or beads functionalized with antibodies.


Patent
Terumo BCT Inc. | Date: 2016-04-07

Embodiments relate to systems and methods for removing beads from fluid that may include cells as well as the beads. Embodiments may utilize one or more: separation chambers, flow cells, magnets, and/or magnetic fields to remove beads from a fluid stream.


Patent
Terumo BCT Inc. and Andreas Hettich GmbH & Co. KG | Date: 2016-02-19

Embodiments of a system box for holding a bag system and methods for separating composite liquids are described. In embodiments, a bag system may be a blood bag system used to collect blood, separate the blood into components, store the components, and utilize the components in patients. The system box may hold the blood bag system. Processes can then be performed to separate components from the blood.


Patent
Terumo BCT Inc. | Date: 2016-04-15

Embodiments of methods and systems are described for automating protein production from genetically modified microorganisms. Embodiments provide for growing modified microorganisms to generate protein, releasing the protein and recovering the protein automatically. Also described are embodiments for lysing cells that may be used to as part of an automated system to recover the protein after generation by the microorganisms.


This invention is directed to methods of directly reseeding harvested adherent cells grown in a hollow fiber bioreactor. Also disclosed is a novel harvest media for use in directly reseeding adherent cells into a hollow fiber bioreactor.

Loading Terumo BCT Inc. collaborators
Loading Terumo BCT Inc. collaborators