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Tanabe J.,Teramoto Memorial Nishitenma Clinic | Yasumaru M.,Sankei Health Insurance Society Clinic | Tsujimoto M.,Osaka Police Hospital | Iijima H.,Osaka University | And 7 more authors.
Clinical Journal of Gastroenterology | Year: 2013

A 25-year-old Japanese female was referred to our clinic for the investigation of moderate iron-deficiency anemia and epigastralgia. Endoscopic examination showed diffuse mucosal nodules in the gastric body resembling nodular gastritis, but this pattern was not observed in the antrum. Histology of the gastric biopsies taken from the gastric body showed mild atrophic mucosa with chronic active inflammation. Some of the biopsy specimens showed deposition of patchy, band-like subepithelial collagen. Four years later, the patient showed no clinical symptoms and signs. A follow-up endoscopic examination showed similar findings, which mimicked pseudopolyposis or a cobblestone-like appearance. The biopsy specimens from the depressed mucosa between the nodules revealed a thickened subepithelial collagen band with no improvement, which led to a diagnosis of collagenous gastritis. Treatment with oral administration of proton-pump inhibitors and histamine-2-receptor antagonists had proved ineffective. To make a correct diagnosis of collagenous gastritis, we should determine the characteristic endoscopic findings and take biopsies from the depressed mucosa between the nodules. © Springer 2013.

Matsunaga N.,Teramoto Memorial Hospital | Nakagawa Y.,Teramoto Memorial Hospital | Yanagawa K.,Teramoto Memorial Hospital
Japanese Journal of Cancer and Chemotherapy | Year: 2014

An 82-year-old man who complained of constipation, anal pain, and bleeding was diagnosed with internal hemorrhoid in another hospital 6 months previously. At the time of our consultation, a tumor was observed in the anal canal. Computed tomography (CT) imaging revealed that the tumor extended to the front of the coccyx with abscess formation. Histological examination of biopsy specimens confirmed a diagnosis of adenocarcinoma. Since the patient refused to undergo surgery, we recommended chemoradiotherapy for relieving pain. A total of 60 Gy of irradiation was administered to the lesser pelvis, and chemotherapy was initiated with S-1 at a dose of 80mg/day for 14 consecutive days followed by 7 days of rest. Subsequently. tumor reduction was seen and the pain was controlled. The patient showed improvement in activities of daily living (ADL). Currently, the patient continues to receive S-1 therapy. We conclude that chemoradiotherapy is useful as a palliative therapy in anal mucinous carcinoma.

Yanagawa K.,Teramoto Memorial Hospital | Matsunaga N.,Teramoto Memorial Hospital | Nakagawa Y.,Teramoto Memorial Hospital
Japanese Journal of Cancer and Chemotherapy | Year: 2014

Aim: Patients undergoing chemotherapy are at risk of carnitine deficiency, and carnitine supplementation has been demonstrated to improve cancer-related fatigue. We examined the changes in fatigue when cancer patients experiencing fatigue while undergoing chemotherapy were administered levocarnitine chloride. Materials and methods. Ten patients with advanced and recurrent cancer experiencing fatigue during chemotherapy were administered levocarnitine chloride. We investigated changes in fatigue, and carried out nutritional assessment using the numerical rating scale (NRS) and geriatric nutritional risk index (GNRI), before and after levocarnitine chloride treatment Results: Four patients responded to levocarnitine chloride treatment, while six did not. Before treatment, the GNRI of responders was significantly lower than that of non- responders. The difference between the two groups disappeared after treatment. Conclusion: A form of malnutrition may have been present in responders, which may have been improved by carnitine supplementation It is possible that an improvement in this nutritional disorder was involved in fatigue mitigation.

Nakagawa Y.,Teramoto Memorial Hospital | Yanagawa K.,Teramoto Memorial Hospital | Matsunaga N.,Teramoto Memorial Hospital | Noda S.,Teramoto Memorial Hospital
Japanese Journal of Cancer and Chemotherapy | Year: 2010

A 70-year-old male presented with gastric cancer with para-aortic lymph node metastasis. The patient was given combination chemotherapy of S-1, paclitaxel and Lentinan. Lymph node metastases were reduced in number at the end of one course. At the end of the eighth course, the lesions were markedly reduced but no further reduction was observed thereafter. The primary lesion was also markedly reduced, and a distal gastrectomy (D1+α) was performed because of remaining tumor tissue detected by biopsy. Pathological findings revealed pT1 (SM), pN0, P0, CY0, H0, M0, and Stage I A, respectively. After surgery, this treatment was continued for 4 years and one month from the initiation of this therapy (2 years and six months from gastrectomy). During the period of treatment, there was no relapse nor serious adverse events.

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