Audubon, PA, United States
Audubon, PA, United States

Time filter

Source Type

Patent
Tengion | Date: 2011-05-03

The present invention relates to the regeneration, reconstruction, augmentation or replacement of luminal organs or tissue structures in a subject in need using scaffolds seeded with autologous or non-autologous cell populations that are or are not derived from the corresponding organ or tissue structure that is the subject of the regeneration, reconstruction, augmentation or replacement.


Patent
Tengion | Date: 2011-11-10

The present invention concerns therapeutic formulations containing active agents, such bioactive cell populations, and methods of making and using the same.


Patent
Tengion | Date: 2012-11-20

The present invention relates to the regeneration, reconstruction, repair, augmentation or replacement of organs or tissue structures using scaffolds and autologous cells that are not derived from such organs or tissues.


Patent
Tengion | Date: 2012-11-05

The present invention concerns bioactive renal cell populations, in particular a B2 cell population comprising an enriched population of tubular cells and wherein the renal cell population is depleted of a B1 cell population, renal cell constructs, and methods of screening test agents using the bioactive renal cell populations.


Patent
Tengion | Date: 2012-10-26

The invention is directed to isolated renal cells, including tubular and erythropoietin (EPO)-producing kidney cell populations, and methods of isolating and culturing the same, as well as methods of treating a subject in need with the cell populations.


Patent
Tengion | Date: 2015-05-06

The present invention concerns a non-biased, combinatorial approach to the identification of components that modulate a regenerative response in a target tissue, thereby restoring or partially restoring homeostasis to the target tissue. The methods of the present invention are based on in vivo testing, with or without prior in vitro predictive functional testing or combinatorial testing.


Patent
Tengion | Date: 2013-09-17

Biocompatible synthetic or natural scaffolds are provided for the reconstruction, repair, augmentation or replacement of organs or tissue structures in a patient in need of such treatment. The scaffolds are shaped to conform to at least a part of the organ or tissue structure and may be seeded with one or more cell populations. Inserts, receptacles and ports are also provided for the attachment of tubular vessels to the neo-organ scaffolds. The seeded scaffolds are implanted into the patient at the site in need of treatment to form an organized organ or tissue structure. The scaffolds may be used to form organs or tissues, such as bladders, urethras, valves, and blood vessels.


Patent
Tengion | Date: 2013-11-13

The invention is directed to isolated renal cells, including tubular and erythropoietin (EPO)-producing kidney cell populations, and methods of isolating and culturing the same, as well as methods of treating a subject in need with the cell populations.


Basu J.,Tengion | Ludlow J.W.,Tengion
Trends in Biotechnology | Year: 2010

As a result of recent successes in regenerative medicine approaches to engineering multiple disparate tubular organs, methodology commonalities are emerging. Principal themes include the importance of a biodegradable scaffold seeded with a population of smooth muscle cells. Such composites trigger a regenerative response following in vivo implantation, resulting in de novo organogenesis. In this review, we examine bladder regeneration as a foundational platform technology to highlight key principles applicable to the regeneration of any tubular organ, and illustrate how these general concepts underlie current strategies to regenerate components of gastrointestinal, vascular, pulmonary and genitourinary systems. We focus on identifying the elements of this platform that have facilitated the transition of tubular organ regeneration from academic proof-of-concept to commercial viability. © 2010 Elsevier Ltd.


News Article | December 5, 2016
Site: www.newsmaker.com.au

Skin is the largest organ in human body which is highly dynamic in nature. It is composed of two layers, the outer layer called epidermis and the inner layer called dermis. Its network of nerves, blood vessels and cells thus acting as a protective armor. It serves the body in diverse ways. Its of paramount importance owning to its protective functionality. The skin’s protective function creates a barrier for internal organs and tissues from toxins, disease-carrying microbes, heat and cold and other dangers present in the environment. It also plays a significant role in regulating the body temperature and preserving body’s fluid balance. Nerves within skin sense the presence of potentially harmful agents, such as bees, and immune cells in the skin help to fight against these malicious agents. For the aforementioned reasons, the loss of skin due to burns or trauma can cause a severe blow to the human body; leading to impairment or sometimes elimination of many vital functions which it typically performs. John F. Burke invented the first synthetic skin, at the Massachusetts Institute of Technology in Cambridge, Massachusetts. Artificial skin considered to be the Holy Grail in treating burn victims for more than hundred years till a flexible material was found. It protects against dehydration and infection, easy to produce from ordinary substance and is completely acceptable by the victim’s immune system. The artificial skin can be easily sterilized and usually stored at room temperature. Skin replacement represents a prospective source of advanced therapy in combating acute and chronic skin wounds. With the capability of large scale production and immediate availability for grafting, its potential for use is easy and relatively economic among the burn patients. Much progress has been made toward the development of artificial skin replacement products. Continued research promises to bring more products to the marketplace, and each new product seems to develop a niche in the field of skin replacement. Increased life expectancy, increasing disposable income and favorable demographics are some of the key factors driving the growth of the global skin replacement market. Bioengineered skin replacements are continually being developed and improved. The next generation of skin replacements will probably evolve from lessons learned from our understanding of wound repair and regeneration. Competition from low-cost substitutes, lack of clinical support are probable factors restraining the growth of the global skin replacement market. The global skin replacement market is broadly classified on the basis of product type, material, end-use industry and geographies. Based on product type, the global skin replacement market is segmented into: Based on material, the global skin replacement market is segmented into: Based on end use industry, the global skin replacement market is segmented into: Though skin replacement is a new technology for emerging economies, but in the developed nations the same technology is in use for few decades. With increasing disposable income and rising urbanization the acceptance of skin replacements is gaining popularity. The global skin replacement market is expected to expand at a promising CAGR during the forecast period (2015-2025). Skin replacement market is still in its early stage of maturity. The global skin replacement market is expected to register an optimistic CAGR for the forecast period. Depending on geographic regions, global skin replacement market is segmented into seven key regions: North America, South America, Eastern Europe, Western Europe, Asia Pacific, Japan, and Middle East & Africa. Some of the key market participants in global skin replacement market are Cellular Dynamics International, Cynata Therapeutics Limited, Platelet BioGenesis, Tengion, TissueGene, Inc.The research report presents a comprehensive assessment of the market and contains thoughtful insights, facts, historical data, and statistically supported and industry-validated market data. It also contains projections using a suitable set of assumptions and methodologies. The research report provides analysis and information according to categories such as market segments, geographies, types.

Loading Tengion collaborators
Loading Tengion collaborators