Palo Alto, CA, United States
Palo Alto, CA, United States
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Glutathione transferases (GSTs) are enzymes that catalyze the conjugation of glutathione (GSH) to a variety of electrophilic substances. Their best known role is as cell housekeepers engaged in the detoxification of xenobiotics. Recently, GSTs have also been shown to act as modulators of signal transduction pathways that control cell proliferation and cell death. Their involvement in cancer cell growth and differentiation, and in the development of resistance to anticancer agents, has made them attractive drug targets. This review is focused on the inhibition of GSTs, in particular GSTP1-1, as a potential therapeutic approach for the treatment of cancer and other diseases associated with aberrant cell proliferation. © 2010 Macmillan Publishers Limited. All rights reserved.


Patent
Telik | Date: 2011-03-04

Crystalline ezatiostat hydrochloride ansolvate form D is more stable and/or more soluble that various solvated crystalline polymorphic forms of ezatiostat hydrochloride.


Patent
Telik | Date: 2013-06-26

This invention relates to substituted thiazoles of formula I:


The invention generally relates to compositions for use in treating myelodysplastic syndrome. In one embodiment, the invention relates to compositions comprising ezatiostat or a salt thereof and lenalidomide for use in treating myelodysplastic syndrome.


This invention relates to methods, assays, devices and systems for identifying patients having a myelodysplastic syndrome for treatment with ezatiostat or a salt thereof, or evaluating the patients response possibility to the treatment by measuring and evaluating the patients gene expression profile. This invention also relates to methods of treating myelodysplastic syndromes.


Patent
Telik | Date: 2012-11-30

Provided herein is an amorphous form of a pharmaceutically acceptable salt of ezatiostat, for example, ezatiostat hydrochloride, compositions, uses and methods of preparation thereof.


Patent
Telik | Date: 2012-12-18

Disclosed herein are substituted thiazoles and their salts that are VEGFR2 kinase inhibitors, useful in the treatment of cancer.


The invention relates to compositions for use in specific treatment regimens for treating myelodysplastic syndrome.


The invention generally relates to compositions for use in the treatment of myelodysplastic syndrome. In one embodiment, the invention relates to compositions for use in treating myelodysplastic syndrome with ezatiostat or a salt thereof in patients who have been treated with a DNA methyltransferase inhibitor by a combination of ezatiostat or a salt thereof and lenalidomide.


This invention generally relates to compositions and methods for treating myelodysplastic syndrome. In one embodiment, this invention relates to methods for treating myelodysplastic syndrome with ezatiostat or a salt thereof and lenalidomide.

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