Tel Aviv University is a public university located in Ramat Aviv, Tel Aviv, Israel. With over 30,000 students, TAU is Israel's largest university.Located in Israel's cultural, financial and technological core, Tel Aviv University is a major center of teaching and research, comprising 9 faculties, 27 schools, 98 departments and nearly 130 research institutes and centers. Wikipedia.
Tel Aviv University | Date: 2017-01-12
An isolated peptide comprising a Huntingtin (Htt) amino acid sequence being no longer than 15 amino acids, wherein said Htt amino acid sequence comprises the sequence X_(1)X_(2)X_(3)X_(4 )X_(5), wherein X_(1 )is a hydrophobic amino acid or threonine, X_(2 )is a hydrophobic amino acid, X_(3 )is a hydrophobic amino acid, X_(4 )is an acidic amino acid and X_(5 )is selected from the group consisting of glycine, serine and alanine, the peptide capable of specifically inhibiting the activity of caspase 6.
Tel Aviv University | Date: 2017-01-06
A conductive nanowire film having a high aspect-ratio metal is described. The nanowire film is produced by inducing metal reduction in a concentrated surfactant solution containing metal precursor ions, a surfactant and a reducing agent. The metal nanostructures demonstrate utility in a great variety of applications.
Tel Aviv University | Date: 2017-01-31
A method of detecting a target within a population of molecules comprising: contacting a plurality of labeled probe molecules with the population of molecules potentially containing a target of the probe molecules; acquiring a probe specific signal emitted by said labeled probe molecules that bound to said target together with a background signal; preferentially modulating said probe specific signal by at least one of modulating said acquisition and modulating an emission of said probe specific signal; and detecting said probe specific signal over said background signal using said preferential modulation.
Tel Aviv University | Date: 2017-05-03
A light-field imaging system and a method for generating light-field image data are presented. The system comprising an imaging lens unit, a detector array and a polychromatic patterned filter located in optical path of collected light, being at an intermediate plane between the lens unit and the detector array. The method comprising: acquiring image data of a region of interest by passing input light coming from said region of interest through said imaging lens unit and said polychromatic patterned filter to be detected by said detector array to generate corresponding image data; and processing said image data to determined light components passing through different regions of said polychromatic patterned filter corresponding to different colors and different parts of the region of interest to provide light-field image data of said region of interest.
University of Maryland, Baltimore and Tel Aviv University | Date: 2017-03-29
The beta 2 subunit of mouse hemoglobin (HBB2) has been identified as soluble factor from mouse lungs that exhibits cytostatic/cytotoxic activity against neuroblastoma lung micrometastases. The beta subunit of human hemoglobin (HBB) has been found to have similar activity. Methods of using these proteins and fragments thereof in the treatment of cancer and inhibition of metastasis are provided, along with methods of screening a subject for micrometastases by detecting HBB in a biological sample.
Tel Aviv University | Date: 2017-02-05
Apparatus and method for efficiently assessing the results of reflectance spectroscopy on a soil sample to determine the presence of contaminants in the soil, by constructing a model based on analysis of known samples. The model may be constructed using an all possibilities approach and data mining techniques, on a range of samples, for example of different kinds of soil without pollutants and with different levels of pollutants. The Disclosure relates both to the construction of the model and to its use in the field in analyzing soil contaminants.
Tel Aviv University | Date: 2017-02-08
An optical element is disclosed. The optical element comprises: a first phase shift mask formed on a first optical material and constituted to generate a positive phase shift, and a second phase shift mask formed on a second optical material and constituted to generate a negative phase shift, wherein the phase shift masks are arranged serially on an optical axis, and wherein a refractive index of at least one of the first and second optical materials varies with the temperature at a rate of at least 5010^(6 )per degree Kelvin.
Tel Aviv University | Date: 2017-01-10
A method of generating a particle is disclosed, the particle being for delivery of a polynucleotide to a target cell. The method comprises (a) contacting the polynucleotide with a composition comprising cationic molecules, wherein the cationic molecules condense the polynucleotide by electrostatic interactions to generate a complex, wherein the cationic molecules are not comprised in a liposome; and (b) covalently binding the complex to a targeting moiety at a pH equal to or below about 4.5, thereby generating the particle for delivery of the polynucleotide agent to the target cell. Use of the particles and compositions comprising same are also disclosed.
Tel Aviv University | Date: 2017-03-02
An antibody is provided. The antibody comprises an Fc region and a Fab region, wherein: Methods of generating same and uses thereof are also provided.
Tel Aviv University | Date: 2017-07-19
The present invention relates to an enzymatic stimuli-responsive amphiphilic hybrid delivery system in micellar form, based on a hydrophilic polyethylene glycol (PEG) polymer conjugated to a hydrophobic dendron. The delivery system disassembles upon enzymatic stimuli/cleavage. The present invention further provides methods of use of the hybrid delivery system and to a kit comprising the same.