Burnaby, Canada

Tekmira Pharmaceuticals

www.tekmira.com/
Burnaby, Canada

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Patent
Tekmira Pharmaceuticals | Date: 2015-10-15

The present invention provides lipids that are advantageously used in lipid particles for the in vivo delivery of therapeutic agents to cells. In particular, the invention provides lipids having the following structure wherein: R_(1 )and R_(2 )are each independently for each occurrence optionally substituted C_(10)-C_(30 )alkyl, optionally substituted C_(10)-C_(30 )alkenyl, optionally substituted C_(10)-C_(30 )alkynyl, optionally substituted C_(10)-C_(30 )acyl, or -linker-ligand; R_(3 )is H, optionally substituted C_(1)-C_(10 )alkyl, optionally substituted C_(2)-C_(10 )alkenyl, optionally substituted C_(2)-C_(10 )alkynyl, alkylhetrocycle, alkylphosphate, alkylphosphorothioate, alkylphosphorodithioate, alkylphosphonates, alkylamines, hydroxyalkyls, -aminoalkyls, -(substituted)aminoalkyls, -phosphoalkyls, -thiophosphoalkyls, optionally substituted polyethylene glycol (PEG, mw 100-40 K), optionally substituted mPEG (mw 120-40 K), heteroaryl, heterocycle, or linker-ligand; and E is C(O)O or OC(O).


Patent
Tekmira Pharmaceuticals | Date: 2015-11-30

The present invention provides lipids that are advantageously used in lipid particles for the in vivo delivery of therapeutic agents to cells. In particular, the invention provides lipids having the following structures:


Patent
Tekmira Pharmaceuticals | Date: 2016-01-29

A lipid particle can include a cationic lipid. The cationic lipid can include one or more hydrophobic tails, which can include one or more sites of unsaturation. The sites of unsaturation can include cycloalkyl groups, e.g., cyclopropyl, cyclobutyl, cyclopentyl, or cyclohexyl groups. The lipid particle is suitable for delivering an active agent.


The invention relates to compositions and methods for site-specific delivery of nucleic acids by combining them with targeting ligands and endosomolytic components.


Patent
Tekmira Pharmaceuticals | Date: 2014-01-07

Compositions and methods useful in administering nucleic acid based therapies, for example association complexes such as liposomes and lipoplexes are described.


Patent
Tekmira Pharmaceuticals | Date: 2015-02-24

The present invention provides lipids that are advantageously used in lipid particles for the in vivo delivery of therapeutic agents to cells. In particular, the invention provides lipids having the following structure wherein R_(1 )and R_(2 )are each independently for each occurrence optionally substituted C_(10)-C_(30 )alkyl, optionally substituted C_(10)-C_(30 )alkenyl, optionally substituted C_(10)-C_(30 )alkynyl, optionally substituted C_(10)-C_(30 )acyl, or -linker-ligand; R_(3 )is H, optionally substituted C_(1)-C_(10 )alkyl, optionally substituted C_(2)-C_(10 )alkenyl, optionally substituted C_(2)-C_(10 )alkynyl, alkylhetrocycle, alkylphosphate, alkylphosphorothioate, alkylphosphorodithioate, alkylphosphonates, alkylamines, hydroxyalkyls, -aminoalkyls, -(substituted)aminoalkyls, -phosphoalkyls, -thiophosphoalkyls, optionally substituted polyethylene glycol (PEG, mw 100-40K), optionally substituted mPEG (mw 120-40K), heteroaryl, heterocycle, or linker-ligand; E is O, S, N(Q), C(O), N(Q)C(O), C(O)N(Q), (Q)N(CO)O, O(CO)N(Q), S(O), NS(O)_(2)N(Q), S(O)_(2), N(Q)S(O)_(2), SS, ON, aryl, heteroaryl, cyclic or heterocycle; and, Q is H, alkyl, -aminoalkyl, -(substituted)aminoalky, -phosphoalkyl or -thiophosphoalkyl.


Patent
Tekmira Pharmaceuticals | Date: 2015-04-30

This invention relates to methods for increasing the efficiency of siRNA administrations via pre-administration of an agent that lowers LDL receptor levels.


Patent
Tekmira Pharmaceuticals, University of British Columbia and Acuitas Therapeutics Inc. | Date: 2016-05-11

A lipid particle can include a plurality of cationic lipids, such as a first cationic lipid and a second cationic lipid. The first cationic lipid can be selected on the basis of a first property and the second cationic can be selected on the basis of a second property. The first and second properties are complementary. The attributes of the lipid particle can reflect the selected properties of the cationic lipids, and the complementary nature of those properties.


Patent
University of British Columbia and Tekmira Pharmaceuticals | Date: 2015-08-28

The present invention provides superior compositions and methods for the delivery of therapeutic agents to cells. In particular, these include novel lipids and nucleic acid-lipid particles that provide efficient encapsulation of nucleic acids and efficient delivery of the encapsulated nucleic acid to cells in vivo. The compositions of the present invention are highly potent, thereby allowing effective knock-down of specific target proteins at relatively low doses. In addition, the compositions and methods of the present invention are less toxic and provide a greater therapeutic index compared to compositions and methods previously known in the art.


Patent
Tekmira Pharmaceuticals | Date: 2015-10-30

The invention features a method of identifying therapeutically relevant compositions which include a therapeutic agent and 2,2-dimethylaminomethyl-[1-3]-dioxolane by screening for an effect of the agent on the liver of a model subject.

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