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Barddhamān, India

Dan S.,Medical College | Aditya P.,Tejganj High School | Samanta M.,Sri Ramachandra University | Jothimalar R.,Sri Ramachandra University | Soundarajan P.,Sri Ramachandra University
Diabetes Research and Clinical Practice | Year: 2014

Aims: We evaluated the relationship between iPTH levels and glycemic control in patients with diabetes and end stage renal disease (ESRD) on maintenance hemodialysis (MHD). Methods: The study included 98 subjects with ESRD and type 2 diabetes aged 30-75 years who were on MHD. These were divided into two groups - patients with HbA1c >7.0 (53. mmol/mol) (poor glycemic control group) and patients with HbA1c <7.0 (53. mmol/mol) (good glycemic control group). All patients had been on regular bicarbonate haemodialysis for more than 6 months using polysulfone membrane dialyzer; 4. h per episode 3 times/week, with a dialysis fluid of 3.0. mEq/L of calcium concentration. 1-α-(OH)D3 and calcium carbonate were used routinely in all patients. The contribution of each relevant biological parameter to serum iPTH level was assessed using multiple regression test. Results: Poor glycemic control was associated with reduced serum iPTH level and good glycemic control with higher serum iPTH. The serum HbA1c level was significantly correlated with the serum iPTH level (p=0.0003). Conclusions: Glycemic control is a significant determinant of iPTH level in diabetic ESRD patients on MHD. © 2014 Elsevier Ireland Ltd.

Dan S.,Calcutta Medical College | Aditya P.,Calcutta Medical College | Banerjee P.,Calcutta Medical College | Bal C.,Calcutta Medical College | And 2 more authors.
Nigerian Journal of Clinical Practice | Year: 2014

Background: Chronic Kidney Diseases (CKD) of all etiologies are usually associated with Insulin Resistance (IR). Resistin is also a protein associated with IR. Some studies conducted abroad have shown that resistin level is higher among CKD patients.Objective: To test if serum resistin level is significantly higher in CKD patients compared to normal individuals. Patients and Methods: 96 CKD patients and 97 normal individuals were included in the study. Written informed consent was obtained from every individual.Results: Serum resistin level was higher in CKD patients compared to control subjects. The difference in serum resistin level between two groups was statistically significant.Conclusion: Our study is probably the first study in India comparing serum resistin levels of CKD patients vis-à-vis control subjects. Further cellular research may be needed to explore this relation.

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