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Ichihara, Japan

Teikyō Heisei University is a private university in Ichihara, Chiba, Japan, established in 1987. Wikipedia.

Hagihara A.,Kyushu University | Miyazaki S.,Kyushu University | Miyazaki S.,Teikyo Heisei University | Abe T.,Kyushu University
European Archives of Psychiatry and Clinical Neuroscience

Although several case reports have suggested a relationship between accessing Internet suicide sites and the incidence of suicide, the influence of the Internet on the incidence of suicide is not known. Thus, we examined the association between Internet suicide-related searches and the incidence of suicide in 20-and 30-year-old individuals in Japan. The Box-Jenkins transfer function model was applied to monthly time series data from January 2004 to May 2010 (77 months). The terms ''hydrogen sulfide, '' ''hydrogen sulfide suicide, '' and ''suicide hydrogen sulfide suicide'' at (t-11) were related to the incidence of suicide among people aged in their 20 s (P = 0.005, 0.005, and 0.006, respectively) and people aged in their 30 s (P = 0.013, 0.011, and 0.012, respectively). ''BBS on suicide'' at (t-5) and ''suicide by jumping'' at (t-6) were related to the incidence of suicide in people aged 30-39 (P = 0.006 and 0.001, respectively). Internet searches for specific suicide-related terms are related to the incidence of suicide among 20-and 30-year-old individuals in Japan. Routine interrogation by a clinician about visiting Internet suicide websites and stricter regulation of these websites may reduce the incidence of suicide among young people. © 2011 Springer-Verlag. Source

Yamaguchi Y.,Teikyo Heisei University | Tanikawa K.,Japan National Astronomical Observatory
Progress of Theoretical Physics

A certain region in the phase space for the area- and orientation- preserving Hénon map is filled with the resonance chains. Taking this fact into account, the concept of block word has been introduced in the preceding paper. The concept of resonance chains in the symbol plane is also introduced and the marquetry structure of the symbol plane is investigated. If the orbit in the horseshoe travels over the resonance chains, the orbit is represented by a block word sequence. There are four purposes discussed in this paper. The first purpose is to introduce a, new concept of parity to characterize the periodic orbits. The second is to study the detailed structure of the symbol plane. The third is to clarify the behaviors of symmetric periodic orbits in the resonance chain and determine their block word sequences. The fourth is to propose an improved construction method to make a braid for a, non-Birkhoff periodic orbit in a resonance chain. Source

Yanagisawa O.,Waseda University | Kurihara T.,Ritsumeikan University | Kobayashi N.,Teikyo Heisei University | Fukubayashi T.,Waseda University
Journal of Magnetic Resonance Imaging

Purpose: To assess the effects of strenuous exercise on magnetic resonance diffusion parameters and muscle-tendon complex function in skeletal muscle. Materials and Methods: Six men performed ankle plantar flexion exercises with eccentric contraction. The fractional anisotropy (FA), λ 1, λ 2, λ 3, mean diffusivity (MD), and T 2 values in the triceps surae muscles were measured by magnetic resonance diffusion tensor and spin-echo imaging. Passive torque of plantar flexors, maximal voluntary isometric plantar flexion torques (MVIP), and Achilles tendon stiffness during MVIP were measured by combined ultrasonography and dynamometry. Plasma creatine kinase and muscle soreness were also assessed. These parameters were measured before and 1-8 days postexercise. Results: The medial gastrocnemius exhibited significantly decreased FA 2-5 days after, increased λ 2 3 days after, and increased λ 3 2 and 3 days after exercise. This muscle also showed significantly increased MD and T 2 values 3 days postexercise. MVIP significantly decreased 2 and 3 days postexercise, while passive torque significantly increased 2 days postexercise. Creatine kinase and muscle soreness increased 3-5 days and 1-5 days postexercise, respectively. Conclusion: Exercise-induced muscle damage manifested as significant changes in muscle diffusion parameters with muscle-tendon complex dysfunction and delayed-onset muscle soreness. Copyright © 2011 Wiley-Liss, Inc. Source

Kodama H.,Teikyo University | Kodama H.,Teikyo Heisei University | Fujisawa C.,Teikyo University | Bhadhprasit W.,Teikyo University
Current Drug Metabolism

Copper is an essential trace element required by all living organisms. Excess amounts of copper, however, results in cellular damage. Disruptions to normal copper homeostasis are hallmarks of three genetic disorders: Menkes disease, occipital horn syndrome, and Wilson's disease. Menkes disease and occipital horn syndrome are characterized by copper deficiency. Typical features of Menkes disease result from low copper-dependent enzyme activity. Standard treatment involves parenteral administration of copper-histidine. If treatment is initiated before 2 months of age, neurodegeneration can be prevented, while delayed treatment is utterly ineffective. Thus, neonatal mass screening should be implemented. Meanwhile, connective tissue disorders cannot be improved by copper-histidine treatment. Combination therapy with copper-histidine injections and oral administration of disulfiram is being investigated. Occipital horn syndrome characterized by connective tissue abnormalities is the mildest form of Menkes disease. Treatment has not been conducted for this syndrome. Wilson's disease is characterized by copper toxicity that typically affects the hepatic and nervous systems severely. Various other symptoms are observed as well, yet its early diagnosis is sometimes difficult. Chelating agents and zinc are effective treatments, but are inefficient in most patients with fulminant hepatic failure. In addition, some patients with neurological Wilson's disease worsen or show poor response to chelating agents. Since early treatment is critical, a screening system for Wilson's disease should be implemented in infants. Patients with Wilson's disease may be at risk of developing hepatocellular carcinoma. Understanding the link between Wilson's disease and hepatocellular carcinoma will be beneficial for disease treatment and prevention. © 2012 Bentham Science Publishers. Source

Obinata T.,Teikyo Heisei University | Ono K.,Emory University | Ono S.,Emory University
Journal of Cell Science

The myoepithelial sheath of the Caenorhabditis elegans somatic gonad has non-striated actomyosin networks that provide contractile forces during ovulation, a process in which a mature oocyte is expelled from the ovary. Troponin T and troponin C are known regulators of contraction of the myoepithelial sheath. These are two of the three components of the troponin complex that is generally considered as a striated-muscle-specific regulator of actomyosin contraction. Here, we report identification of troponin I as the third component of the troponin complex that regulates ovulatory contraction of the myoepithelial sheath. C. elegans has four genes encoding troponin-I isoforms. We found that tni-1 and unc-27 (also known as tni-2) encode two major troponin-I isoforms in the myoepithelial sheath. Combination of RNA interference and mutation of tni-1 and unc-27 resulted in loss of the troponin-I protein in the gonad and caused sterility due to defective contraction of the myoepithelial sheath. Troponin-I-depleted gonads were hypercontracted, which is consistent with the function of troponin I as an inhibitor of actomyosin contraction. Troponin I was associated with nonstriated actin networks in a tropomyosin-dependent manner. Our results demonstrate that troponin I regulates contraction of nonstriated actomyosin networks and is an essential cytoskeletal component of the C. elegans reproductive system. Source

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