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Agarwal S.,Teerthanker Mahaveer Medical College and Research Center | Agarwal A.,Teerthanker Mahaveer Medical College and Research Center | Khanna A.,Institute of Medical science | Singh K.,BHU
Journal of Human Reproductive Sciences | Year: 2015

CONTEXT: In majority of couples experiencing recurrent pregnancy loss (RPL), etiology is still unknown. Two genetic factors have been suggested to underlie miscarriage in a subset of patients, namely skewed X chromosome inactivation in females and Y chromosome microdeletions in their partners. In males, microdeletions of the Y chromosome are known to cause spermatogenetic failure and male infertility. AIMS: The aim of the study was to find out the role of Y chromosome microdeletion in male partners of couples experiencing RPL. SETTINGS AND DESIGN: University hospital and genetic laboratory. Prospective case-control study. SUBJECTS AND METHODS: 59 couples with a history of RPL and 20 fertile controls (FC) with no miscarriage were included in the study. The study subjects were divided into male partners of RPL couples with abnormal semen parameters (AS) (n = 8), and couples with normal semen parameters (NS) (n = 51). Fertile controls with normal semen parameters were (FC) (n = 20). Y chromosome microdeletion was performed on 40 male partners of RPL and 20 FC. STATISTICAL ANALYSIS USED: Chi-square test. P <0.05 were considered statistically significant. RESULTS: 13 of the 40 RPL cases showed deletion in three azoospermia factor loci on the long arm of Y chromosome. The P value was significant with Y chromosome microdeletion in RPL cases as compared to 20 FC where no Y chromosome microdeletion was present. CONCLUSIONS: Y chromosome microdeletion may be an important hidden cause of recurrent pregnancy miscarriage and can be offered to couples with the undiagnosed cause of miscarriage. © 2015 Journal of Human Reproductive Sciences | Published by Wolters Kluwer - Medknow. Source

Chandak S.,Teerthanker Mahaveer Medical College and Research Center | Kumar A.,Teerthanker Mahaveer Medical College and Research Center
North American Journal of Medical Sciences | Year: 2016

Background: Dengue fever (DF) is a viral hemorrhagic fever causing severe morbidity and mortality in affected patients. Aims: The purpose of our study was to evaluate the changing trends in radiological findings in DF, to find if ultrasound is useful in the diagnosis of DF during an epidemic in absence of serological tests, and also to investigate the effects of DF in pregnancy. Materials and Methods: A prospective study was conducted in 2013 comprising of 400 patients who were serologically positive for dengue. Out of these, radiological investigations were conducted for 107 patients who were analyzed. Results: Out of the 107 patients, 85 patients underwent ultrasound, 12 computed tomography (CT) scans of brain or paranasal sinuses, and 21 chest radiography. The maximum numbers of patients (79%) were in the age group of 20-50 years. The most common ultrasound finding was hepatomegaly that was seen in 62% of the patients. Other findings were splenomegaly (45%), gallbladder (GB) wall edema (45%), right-sided pleural effusion (37%), bilateral pleural effusion (22%), and ascites (36%). Out of 10 pregnant patients, 5 had oligohydramnios, 2 had intrauterine growth restriction, 2 had intrauterine fetal demise, and 5 had a normal antenatal ultrasound. Conclusion: Ultrasound findings of hepatosplenomegaly, GB wall edema, right-sided or bilateral pleural effusion, and ascites in patients presenting with signs and symptoms of DF during an epidemic are virtually diagnostic of DF. There have been recent changing trends with hepatosplenomegaly being the more common manifestation, in comparison to ascites and GB wall edema. DF also has catastrophic effects in pregnancy such as oligohydramnios and intrauterine fetal demise. © 2016 North American Journal of Medical Sciences. Source

Rastogi R.,Teerthanker Mahaveer Medical College and Research Center | Bhargava S.,Teerthanker Mahaveer Medical College and Research Center
Journal International Medical Sciences Academy | Year: 2015

Vitamin-D deficiency has shown an increased incidence in our present society irrespective of the socio-economic strata. It is multifactorial in origin. It may manifest as rickets in children and osteomalacia in adults, both of which are characterized by increase in non-mineralized osteoid formation. The condition is not uncommon in neonates. In this article, we will review the radiological manifestations of vitamin-D deficiency. Source

Khan F.A.,Teerthanker Mahaveer Medical College and Research Center | Mishra H.,Teerthanker Mahaveer Medical College and Research Center
Asian Journal of Pharmaceutical and Clinical Research | Year: 2011

Introduction: Non-steroidal anti-inflammatory drugs are commonly prescribed in cases of inflammatory conditions. Earlier little was known about the immunomodulatory role of Nsaids, particularly selective Cox-2 inhibitors as immunosuppressants. This study was conducted to observe the in vivo effect of Cox 2 inhibition on immune response. Material & methods: Albino Rabbits of either sex were divided into three groups of six animals each and were administered Meloxicam (2 mg/kg, OD, p.o), Etoricoxib (17 mg/kg O.D, p.o) and Normal Saline (acting as Control) for seven days starting one day prior to immunization by S. Typhi Antigen (0.5 ml in each thighs). The antibody titre were measured weekly for one month using Widal Agglutination test. Results: The antibody titres in the first week were found raised in all the groups but the response was more marked in treated group as compared to Control group. After 1 stweek antibody titre fell markedly in the treated groups. Etoricoxib administration caused higher antibody suppression in comparison to Meloxicam treated group. Conclusions: Our results suggest that NSAIDs and significantly Cox-2-selective drugs attenuate antibody production. Use of NSAIDs may therefore be beneficial in decreasing autoantibody production in autoimmune diseases and may be harmful in response to antigenic challenge/vaccination as they dampen humoral immunity. Source

Agarwal S.,Teerthanker Mahaveer Medical College and Research Center | Shamshad M.A.,Dr Shroff Charity Eye Hospital | Goel D.,Teerthanker Mahaveer Medical College and Research Center | Ansari M.,Teerthanker Mahaveer Medical College and Research Center
Journal of Clinical and Diagnostic Research | Year: 2013

Introduction: Glaucoma is the leading cause of blindness in India and the numbers of the patients are increasing every day. The prevalence of glaucoma depends upon various factors like racial and ethnic factors, the socioeconomic status, etc. Aim: To study the pattern of glaucoma distribution among the patients in a tertiary care hospital. Materials and Methods: A retrospective analysis of 1500 glaucoma patients was done, who presented between 2007 and 2012 in TMMC and RC, Moradabad, U.P, India. The age and the gender distribution of glaucoma was studied along with its subtypes in different religious groups (mainly among Hindus and Muslims). Results: The mean age of the glaucoma patients was 52.7 years. Glaucoma was diagnosed in 882(58.8%) Muslim and in 561(37.4%) Hindu patients. The prevalence of POAG (33.0%) was almost equal to that of PACG (32.7%). POAG was the most common type of glaucoma in males (16.8%), while PACG was very common among females (18.8%). In Hindu patients, POAG (40.8%) was the commonest form of glaucoma, while in Muslims, PACG (40.1%) was the highest form of glaucoma. Conclusion: Glaucoma is a major ocular disease which is prevalent in the Muslim population of the western Uttar Pradesh region. Source

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