Agency: Cordis | Branch: FP7 | Program: CP-IP | Phase: HEALTH.2013.2.1.1-1 | Award Amount: 15.78M | Year: 2013
The aim of SYBIL is to carry out extensive functional validation of the genetic determinants of rare and common skeletal diseases and the age related factors contributing to these painful conditions. To achieve this goal SYBIL will gather complementary translational and transnational scientists, systems biologists, disease modellers, leading SMEs and industrialists that will perform in-depth characterisation (complete molecular phenotyping) of pre-clinical models (cellular and animal) for a variety of common and rare skeletal diseases. SYBIL will establish a systematic pipeline of in vitro, ex vivo and in vivo models of increasing complexity and will also make use of novel technologies such as iPS cells and exclusive Virtual Patient software to identify potential therapeutic targets for further validation through simultaneous modelling of fundamental and complex physiological pathways. SYBIL will rely on i) an Omics Knowledge Factory for systematically generating new knowledge on skeletal disease pathophysiology and to generate the relevant Omics profiles necessary to detect and validate new disease determinants, biomarkers and therapeutic targets for future clinical developments, and ii) a Systems Biology Hub to integrate the high-throughput and data-dense information, to gain a global understanding of pathophysiological commonalities between different skeletal diseases and recognize predominant shared pathways and mechanisms that may represent new targeted routes to treatment. SYBIL will also identify potential modifier genes and study the epigenome that will ultimately influence the timing and efficacy of new personalised treatments. Overall SYBIL achievements will tremendously boost the efficient pre-clinical assessment and development of therapeutics against skeletal diseases and thus indirectly reduce their social and healthcare burden.
Technology Associates | Date: 2015-03-09
Methods and systems for child authentication are described. In one embodiment, a communication enablement request may be received to enable electronic communications between a first child and a second child. A confirmation acceptance code may be electronically generated. The confirmation acceptance code may be associated with the first child and the second child. The confirmation acceptance code may be received from a parental representative of the second child. The electronic communication may be enabled between the first child and the second child based on the receiving of the confirmation acceptance code from the parental representative of the second child. Additional methods and systems are disclosed.
Technology Associates | Date: 2010-07-19
A communication includes an analog input configured to receive an analog signal. An analog to digital converter is configured to provide a digital signal output based upon the analog input. A modulator is configured to modulate a laser based upon the digital signal thereby generating a modulated optical signal. An optical fiber carries the modulated optical signal and an optical detector arranged to receive the modulated optical signal from the optical fiber and provide a received output. A digital to analog converter digitizes the received output and provides an analog output based respective of the analog signal provided to the analog input.
Technology Associates | Date: 2016-02-12
A method comprises storing, at the server computer system, user profile information for the remote user. The user profile information for the remote user (or a link to the user profile information) is encrypted using authentication information. The user profile information is associated with user identification information, at the server computer system, using the authentication information, which is selectively made available by the remote user via the network to the server computer system in order to enable the server computer system to associate the user profile information with the user identification information.
Technology Associates | Date: 2014-07-01
Methods and systems consistent with this invention receive a plurality of transmitted signals in a receiver having a plurality of receive elements, wherein each transmitted signal has a different spatial location. Such methods and systems receive the plurality of transmitted signals at the plurality of receive elements to form a plurality of receive element signals, form a combined signal derived from the plurality of receive element signals, and detect each of the plurality of transmitted signals from the combined signal by its different spatial location. To achieve this, methods and systems consistent with this invention generate a plurality of arbitrary phase modulation signals, and phase modulate each of the plurality of receive element signals with a different one of the phase modulation signals to form a plurality of phase modulated signals. Such methods and systems then combine the plurality of phase modulated signals into a combined signal, generate expected signals, and cross-correlate the combined signal with the expected signals to form correlation signals. Such methods and systems then store the correlation signals in a correlation signal memory and analyze the correlation signals to extract information from the transmitted signals.
Technology Associates | Date: 2015-11-24
software for use in the telecommunications industry, namely, software for improving network performance and network optimization.
Technology Associates | Date: 2015-11-27
Computer software that provides web-based access to applications and services through a web operating system or portal interface.
Technology Associates | Date: 2016-06-29
Agency: Department of Defense | Branch: Navy | Program: STTR | Phase: Phase I | Award Amount: 79.89K | Year: 2016
Disruptive Technology Associates will develop additive manufacturing (3-D printing) techniques for microwave vacuum electronics that will change the supply chain, allowing vacuum electronics units to be built with lower overall cost while supporting a sporadic ordering cycle. The Phase I program address several key material and materials integration risk areas. The program will assess several types of additive fabrication solutions for achieving components with the necessary vacuum-compatibility, and thermal, electrical, and magnetic properties needed for a successful design. The program also explores vacuum electronics design changes and tradeoffs that have the potential to facilitate cost-saving additive manufacturing approaches or employ new additive geometries to enhance performance. At the completion of Phase I, the team will have identified and de-risked the most promising approaches for achieving high quality parts that can be commercially produced, thereby laying the foundation for developing process and equipment in Phase II that can be widely adopted by the industry.