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Marchenko V.M.,Technological University
European Control Conference, ECC 1999 - Conference Proceedings | Year: 2015

Several classes of non-singular functional transformations for linear stationary dynamical systems with retarded argument are introduced. Then, the problem of determination of canonical forms is interpreted as the algebraic problem of universality for each class of transformations. Generalization of Kalman, Popov and Brunovsky canonical representations are given for systems of control and observation with after-effect. By using the results obtained, the main qualitative control theory problems such as controllability, stabilization, observability, modal control, reconstruction, and others can be successfully investigated for various types of functional-differential systems under action of several kinds of linear difference state feedback. © 1999 EUCA. Source

Antonov A.V.,University of Leicester | Antonov A.V.,Technological University | Krestyaninova M.,University of Helsinki | Knight R.A.,University of Leicester | And 5 more authors.
Oncogene | Year: 2014

Multiple clinical studies have correlated gene expression with survival outcome in cancer on a genome-wide scale. However, in many cases, no obvious correlation between expression of well-known tumour-related genes (that is, p53, p73 and p21) and survival rates of patients has been observed. This can be mainly explained by the complex molecular mechanisms involved in cancer, which mask the clinical relevance of a gene with multiple functions if only gene expression status is considered. As we demonstrate here, in many such cases, the expression of the gene interaction partners (gene 'interactome') correlates significantly with cancer survival and is indicative of the role of that gene in cancer. On the basis of this principle, we have implemented a free online datamining tool (http://www.bioprofiling.de/PPISURV). PPISURV automatically correlates expression of an input gene interactome with survival rates on >40 publicly available clinical expression data sets covering various tumours involving about 8000 patients in total. To derive the query gene interactome, PPISURV employs several public databases including protein-protein interactions, regulatory and signalling pathways and protein post-translational modifications. © 2014 Macmillan Publishers Limited. Source

Mon M.M.,Mandalay University | Maw S.S.,Mandalay University | Oo Z.K.,Technological University
World Academy of Science, Engineering and Technology | Year: 2011

Antioxidant activities of ethanolic extracts of Ardisia japonica Blume., Ageartum conyzoides Linn., and Cocculus hirsutus Linn Diels. leaves was determined qualitatively and quantitatively in this research. 1, 1-diphenyl-2-picrylhydrazyl (DPPH) free radical solution was used to investigate free radical scavenging activity of these leaves extracts. Ascorbic acid (Vitamin C) was used as the standard. In the present investigation, it is found that all of these extracts have remarkable antioxidant activities. The EC50 values of these ethanolic extracts were 12.72 μg/ml for A. japonica, 15.19 μg/ml for A. conyzoides, 10.68 μg/ml for C. hirsutus respectively. Among these Myanmar medicinal plants, C. hirsutus showed higher antioxidant activities as well as free radical scavenging activity than black tea (Camellia sinensis), the famous antioxidant, and A. japonica and A. conyzoides showed a rather lower antioxidant activity than tea extracts. According to results from bioassay with carrot discs infected with Agrobacterium tumefaciens, all extracts showed anti-tumor activity after 3 weeks of incubation. No gall was detected in carrot disks treated with C. hirsutus and A. japonica extracts in the dose of 100ppm and in carrot discs treated with A. conyzoides extract in the dose of 1000 ppm. Therefore, the research clearly indicates that these weedy plants of dry farm land are exceptionally advantageous for human health. Source

Amelio I.,University of Leicester | Antonov A.A.,University of Leicester | Catani M.V.,University of Rome Tor Vergata | Massoud R.,University of Rome Tor Vergata | And 6 more authors.
Oncotarget | Year: 2014

Metabolic adaptation has emerged as a hallmark of cancer and a promising therapeutic target, as rapidly proliferating cancer cells adapt their metabolism increasing nutrient uptake and reorganizing metabolic fluxes to support biosynthesis. The transcription factor p73 belongs to the p53-family and regulates tumorigenesis via its two N-terminal isoforms, with (TAp73) or without (ΔNp73) a transactivation domain. TAp73 acts as tumor suppressor, at least partially through induction of cell cycle arrest and apoptosis and through regulation of genomic stability. Here, we sought to investigate whether TAp73 also affects metabolic profiling of cancer cells. Using high throughput metabolomics, we unveil a thorough and unexpected role for TAp73 in promoting Warburg effect and cellular metabolism. TAp73-expressing cells show increased rate of glycolysis, higher amino acid uptake and increased levels and biosynthesis of acetyl-CoA. Moreover, we report an extensive TAp73-mediated upregulation of several anabolic pathways including polyamine and synthesis of membrane phospholipids. TAp73 expression also increases cellular methyl-donor S-adenosylmethionine (SAM), possibly influencing methylation and epigenetics, and promotes arginine metabolism, suggestive of a role in extracellular matrix (ECM) modeling. In summary, our data indicate that TAp73 regulates multiple metabolic pathways that impinge on numerous cellular functions, but that, overall, converge to sustain cell growth and proliferation. Source

Afanas'ev V.N.,Technological University
Journal of Computer and Systems Sciences International | Year: 2010

Quite many engineering problems, problems from ecology, medicine, and social sciences are characterized by the presence of factors bringing uncertainty into the corresponding control systems. Additional difficulties for control action construction arise in the case when the objects are described by nonlinear high-order evolutionary equations. An important subset of these objects consists of the object with interval parametric uncertainty with a given control objective and with a given a given termination time of the transient process. For this objects, one of the possible ways of control action synthesis is the application of the guaranteed control concept. We propose the method of control synthesis for one class of nonlinear uncertain objects with using their robust models having linear structure and the parameters, depending on their state. © 2010 Pleiades Publishing, Ltd. Source

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