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Athens, Greece

The Technological Educational Institute of Athens is a higher-educational institute supervised by the Minister of Education, Lifelong Learning and Religious Affairs. It is the third largest Institution of Higher Education in Greece, with approximately 35.000 students, a regular faculty of 600 and a temporary faculty of 1700 academics. The Technological Educational Institute of Athens offers undergraduates and postgraduates studies. Wikipedia.

Alexandridis A.,Technological Educational Institute of Athens
International Journal of Neural Systems

This work presents an adaptive framework for building soft-sensors based on radial basis function (RBF) neural network models. The adaptive fuzzy means algorithm is utilized in order to evolve an RBF network, which approximates the unknown system based on input-output data from it. The methodology gradually builds the RBF network model, based on two separate levels of adaptation: On the first level, the structure of the hidden layer is modified by adding or deleting RBF centers, while on the second level, the synaptic weights are adjusted with the recursive least squares with exponential forgetting algorithm. The proposed approach is tested on two different systems, namely a simulated nonlinear DC Motor and a real industrial reactor. The results show that the produced soft-sensors can be successfully applied to model the two nonlinear systems. A comparison with two different adaptive modeling techniques, namely a dynamic evolving neural-fuzzy inference system (DENFIS) and neural networks trained with online backpropagation, highlights the advantages of the proposed methodology. © World Scientific Publishing Company. Source

Yiannakopoulou E.C.,Technological Educational Institute of Athens
Free Radical Research

Green tea polyphenols, the most interesting constituent of green tea leaves, have been shown to have both pro-oxidant and antioxidant properties. Both pro-oxidant and antioxidant properties are expected to contribute to modulation of oxidative stress response under ideal optimal dosage regimens. Exposure to a low concentration of a pro-oxidant prior to exposure to oxidative stress induces the expression of genes that code for proteins that induce adaptation in a subsequent oxidative stress. On the other hand, exposure to an antioxidant concurrently with exposure to the oxidative stress affords protection through free radical scavenging or through other indirect antioxidant mechanisms. In any case, the optimal conditions that afford protection from oxidative stress should be defined for any substance with redox properties. Green tea polyphenols, being naturally occurring substances, seem to be an ideal option for the modulation of oxidative stress response. This paper reviews available data on the pro-oxidant and antioxidant properties of green tea polyphenols focusing on their potential on the modulation of oxidative stress response. © 2013 Informa UK, Ltd. Source

Markou G.,Agricultural University of Athens | Nerantzis E.,Technological Educational Institute of Athens
Biotechnology Advances

Microalgal biomass as feedstock for biofuel production is an attracting alternative to terrestrial plant utilization for biofuels production. However, today the microalgal cultivation systems for energy production purposes seem not yet to be economically feasible. Microalgae, though cultivated under stress conditions, such as nutrient starvation, high salinity, high temperature etc. accumulate considerable amounts (up to 60-65% of dry weight) of lipids or carbohydrates along with several secondary metabolites. Especially some of the latter are valuable compounds with an enormous range of industrial applications. The simultaneous production of lipids or carbohydrates for biofuel production and of secondary metabolites in a biorefinery concept might allow the microalgal production to be economically feasible. This paper aims to provide a review on the available literature about the cultivation of microalgae for the accumulation of high-value compounds along with lipids or carbohydrates focusing on stress cultivation conditions. © 2013 Elsevier Inc. Source

Yiannakopoulou E.,Technological Educational Institute of Athens
International Journal of Colorectal Disease

Purpose: The main Purpose: of this study was to investigate the efficacy and safety of botulinum toxin in the treatment of anal fissure. An answer was attempted to the following research questions: (i) what is the efficacy of botulinum toxin in healing of anal fissure compared to placebo, (ii) what is the efficacy of botulinum toxin in healing of anal fissure compared to other means of chemical sphincterotomy, (iii) what is the efficacy of botulinum toxin in healing of anal fissure compared to surgical sphincterotomy, (iv) what is the short term safety of botulinum toxin injections and (v) what is the long term safety of botulinum toxin injections. Methods: Clinical trials investigating the effect of botulinum toxin in the treatment of anal fissure met inclusion criteria. Case reports and case series were also included for the estimation of safety. Meta-analysis was not performed due to clinical heterogeneity. Results: The comparator could be placebo, nitroglycerin ointment, or lateral internal sphincterotomy, with dosage ranging from 20 IU to 50 IU of botulinum toxin. Fissure healing was the most commonly reported primary endpoint but the time period from botulinum toxin injection to fissure healing ranged from 2 weeks to 4 months. Accordingly, outcome data were also heterogenous. Conclusions: Botulinum toxin injections should be considered a minimally invasive therapeutic option for the treatment of chronic anal fissure. However, well designed randomized trials are needed for the valid estimation of the efficacy and safety of botulinum toxin in this therapeutic indication. © 2011 Springer-Verlag. Source

Ch Yiannakopoulou E.,Technological Educational Institute of Athens
Pharmacogenomics Journal

The clinical impact of pharmacogenomics remains a hot topic of current research efforts. Although pharmacogenomics of phase I metabolizing enzymes seems to have been well studied, knowledge on the clinical impact of genetic variability of phase II metabolizing enzymes and drug transporters is more limited. This paper reviews data on the pharmacogenomics of phase II metabolizing enzymes as well as of ATP binding cassette transporters and of solute carrier transporters focusing on clinical implications for drug efficacy and drug toxicity. The clinical impact of some of these polymorphisms has been well defined i.e. the association between polymorphisms of organic anion transporter polypeptides and statin induced myopathy. However, as the same drug may be substrate for different enzymes and different transporters, it is difficult to elucidate the impact of each polymorphism. Investigating the impact of multiple polymorphisms might be more clinically meaningful, although methodologically challenging. © 2013 Macmillan Publishers Limited All rights reserved. Source

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