Time filter

Source Type

Nadeem S.,Technocrats Institute of Technology Pharmacy
Asian Pacific Journal of Tropical Disease | Year: 2012

Objective: To investigate the synergistic effect of Commiphora mukul (gum resin) and Lagenaria siceraria (fruit) extracts in high fat diet induced obese rats. Methods: Rats were randomly divided into seven groups: (i) non-obese control (NOB), (ii) Obese control (OB), (iii) orlistat (50 mg/kg; p.o.), (iv) ethyl acetate extract of Commiphora mukul (gum resin) (200 mg/kg; p.o.), (v) ethanolic extract of Lagenaria siceraria (fruit) (200 mg/kg; p.o.) were examined individually, (vi) C. mukul and L.siceraria (200 mg/kg; p.o.) and (vii) C. mukul and L.siceraria (400 mg/kg; p.o.)extracts were administered in combination to the high fat-diet-induced obese rats for 30 days to evaluate its synergistic activity. Results: For synergistic effect, after combination treatment caused most significant (P < 0.001) reduction in body weight, fasting blood glucose, serum levels of cholesterol, triglyceride, LDL, VLDL and increase levels of HDL. Conclusions: The result demonstrated that combination C.mukul and L.siceraria has ameliorated the high fat diet induced obesity. © 2012 Asian Pacific Tropical Medicine Press.

Bhaskar V.H.,P.A. College | Balakrishnan N.,Technocrats Institute of Technology Pharmacy
Pharmaceutical Biology | Year: 2010

Pergularia daemia (Forsk.) Chiov. (Asclepiadaceae) is used traditionally as an anthelmintic, laxative, antipyretic, and expectorant, and also used to treat malarial intermittent fever. But the scientific parameters are not yet available to identify the true plant material. In the present investigation, various pharmacognostic standards for P. daemia have been established. Microscopically, thick root and thick taproot of P. daemia showed the presence of periderm, secondary phloem and secondary xylem. Abundant starch grains and calcium oxalate crystals are present in the cortical parenchyma masses included within the xylem. Powdered roots of the plant showed vessel elements, tracheids, fibers and xylem parenchyma. Total ash of the root of P. daemia was not more than 5% and water-soluble extractive value was two times higher than alcohol soluble extractive value. Phytochemically, the ethanol and aqueous extracts of the root of P. daemia showed maximum phytochemicals such as alkaloids, glycosides, steroids, flavonoids, saponin, tannin and phenolic compounds, terpenoids, carbohydrates, gums and mucilage. The results of this study should provide a standard for identification and preparation of monograph of this drug.

Ahmed K.,Jaipur National University | Nadeem S.,Technocrats Institute of Technology Pharmacy | Shrivastava B.,Jaipur National University | Sharma P.,Jaipur National University
Chinese Chemical Letters | Year: 2016

The present work describes a facile, one-pot three component environment friendly, green synthesis of a series of 5-(4-methoxyphenyl)-7,7-dimethyl-10-phenyl-7,8-dihydro-5H-indeno[1,2-b]quinoline-9,11(6H,10H)-dione derivatives 8(a-n). 1,3-indanedione, aryl-aldehyde and enaminone was thoroughly ground in the presence of catalytic amount of p-toluene sulfonic acid (p-TSA) to give the titled compounds in good yields. All the synthesized derivatives were evaluated for their anticonvulsant activity using the maximal electroshock (MES) method with phenytoin as a standard drug along with their neurotoxicity effect. Derivatives 8b, 8e and 8k exhibited significant anticonvulsant activity (P <0.001). The neurotoxicity study clearly revealed that all the tested compounds are non-toxic at a dose of 40mg/kg. The molecular modeling studies also predicted good binding interactions of most active molecules with the serotonin 5-HT2A receptor. Therefore, it can be safely concluded that synthesized derivatives 8(a-n) would represent useful leads for further investigation in the development of a new class of anticonvulsant agents. © 2016 Kamaal Ahmed.

Bhaskar V.H.,P.A. College | Balakrishnan N.,Technocrats Institute of Technology Pharmacy
Pharmaceutical Biology | Year: 2010

Context: Pergularia daemia (Forsk) Chiov. (Asclepiadaceae) is a slender, hispid, fetid-smelling perennial climber and has been used for the treatment of inflammation, diabetes, malaria, asthma, and liver disorders. Ethnopharmacological surveys conducted among herbal practitioners of Western Ghats, Tamil Nadu, India, revealed that large numbers of laticiferous plant species are used as a source of herbal therapies, in which Pergularia daemia was commonly used to treat liver disease and jaundice. Objective: The hepatoprotective effect of aqueous and ethanol extracts of Pergularia daemia roots by paracetamol and carbon tetrachloride (CCl4)-induced liver damage in rats was studied. Materials and methods: The aqueous (PdAE) and ethanol (PdEE) extracts of Pergularia daemia were studied for their hepatoprotective effects on paracetamol and CCl4-induced liver damage on Wistar albino rats. The degree of protection was measured by physical changes (liver weight), biochemical (serum gultamic pyruvic transaminase, serum gultamic oxaloacetic transaminase, alkaline phosphatase, direct bilirubin, total bilirubin, cholesterol and decrease in protein), antioxidant enzymes (lipid peroxidation and glutathione levels), and histological changes. Results: Pretreatment with PdAE and PdEE significantly prevented the physical, biochemical, antioxidant enzyme levels and histological changes induced by paracetamol and CCl4 in the liver. The effects of PdAE and PdEE were comparable to that of the standard drug silymarin. The ethanol extract was found to exhibit greater hepatoprotective activity than the aqueous extract. Discussion and conclusion: These results indicate that Pergularia daemia could be useful in preventing chemically induced acute liver injury. From this study it can be concluded that the aqueous and ethanol extracts of P. daemia possess significant hepatoprotective activity. © 2010 Informa Healthcare USA, Inc.

Balakrishnan N.,Technocrats Institute of Technology Pharmacy | Sharma A.,Technocrats Institute of Technology Pharmacy
Asian Journal of Pharmaceutical and Clinical Research | Year: 2013

Starting from ancient period and traditional systems of medicine many medicinal plants are play a vital role in the treatment of several diseases. Medicinal plants possess valuable bioactive compounds that protects human from various complications. Therefore, there is a necessity to explore their uses and to conduct pharmacological studies to find out their therapeutic properties. Hence, the present study aims to open new avenues for the improvement of medicinal uses of fruit of Luffa cylindrica for the selected area for diabetes.

Discover hidden collaborations