Technocrats Institute of Technology Pharmacy

Lal Bahadur Nagar, India

Technocrats Institute of Technology Pharmacy

Lal Bahadur Nagar, India

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Nadeem S.,Technocrats Institute of Technology Pharmacy
Asian Pacific Journal of Tropical Disease | Year: 2012

Objective: To investigate the synergistic effect of Commiphora mukul (gum resin) and Lagenaria siceraria (fruit) extracts in high fat diet induced obese rats. Methods: Rats were randomly divided into seven groups: (i) non-obese control (NOB), (ii) Obese control (OB), (iii) orlistat (50 mg/kg; p.o.), (iv) ethyl acetate extract of Commiphora mukul (gum resin) (200 mg/kg; p.o.), (v) ethanolic extract of Lagenaria siceraria (fruit) (200 mg/kg; p.o.) were examined individually, (vi) C. mukul and L.siceraria (200 mg/kg; p.o.) and (vii) C. mukul and L.siceraria (400 mg/kg; p.o.)extracts were administered in combination to the high fat-diet-induced obese rats for 30 days to evaluate its synergistic activity. Results: For synergistic effect, after combination treatment caused most significant (P < 0.001) reduction in body weight, fasting blood glucose, serum levels of cholesterol, triglyceride, LDL, VLDL and increase levels of HDL. Conclusions: The result demonstrated that combination C.mukul and L.siceraria has ameliorated the high fat diet induced obesity. © 2012 Asian Pacific Tropical Medicine Press.


Balasubramaniam A.,Technocrats Institute of Technology Pharmacy | Chouhan K.S.,Technocrats Institute of Technology Pharmacy | Narware M.K.,Technocrats Institute of Technology Pharmacy
Asian Journal of Chemistry | Year: 2012

A simple, specific, accurate, precise and reproducible method has been developed and validated for the simultaneous estimation of thiocolchicoside and diclofenac potassium in pharmaceutical formulation by UV-spectrophotometry, which includes simultaneous equation method (method A) and absorbance ratio method (method B). For the development of method A, wavelengths were selected as 260 nm λ max for thiocholchicoside and 277 nm λ max for diclofenac potassium, while for method B, 277 nm λ max was selected for the diclofenac potassium and 266 nm was the isoabsorptive point of thiocholchicoside and diclofenac potassium. Both drugs follow Beer-Lambert's law at the selected wavelengths in concentration range of 5-25 μg/mL for thiocholchicoside and 5-25 μg/mL for diclofenac potassium. The per cent recoveries of the drugs were found to be nearly 100 % representing the accuracy of both the methods. Validation of the proposed methods was carried out for its accuracy, precision and ruggedness according to ICH guidelines. The proposed methods can be successfully applied in routine work for the determination of thiocholchicoside and diclofenac potassium in a combined dosage form. Also, the method B can be applied for estimation of thiocholchicoside even in presence of the diclofenac potassium in the formulation matrices without interference.


Balakrishnan N.,Technocrats Institute of Technology Pharmacy | Srivastava M.,Technocrats Institute of Technology Pharmacy | Tiwari P.,Technocrats Institute of Technology Pharmacy
Pakistan Journal of Biological Sciences | Year: 2013

Oxidative stress is one of the major causative factors of many chronic and degenerative diseases. Plants have been used in traditional medicine in different parts of world for thousands of years and continue to provide new remedies for human kind. The present study was to investigate the preliminary phytochemical analysis of various extracts of roots and leaves of Trewia nudiflora (Euphorbiaceae) and antioxidant activity by 1, 1, diphenyl-2-picryl hydrazyl (DPPH) radical scavenging method. The preliminary phytochemical screening showed the presence of several phytochemicals including alkaloids, glycosides, flavonoids, steroids, phenolic compounds and tannins. The ethanol and aqueous extracts of roots and leaves of Trewia nudiflora showed significant antioxidant activity compared to standard drug ascorbic acid. © 2013 Asian Network for Scientific Information.


Balakrishnan N.,Technocrats Institute of Technology Pharmacy | Sharma A.,Technocrats Institute of Technology Pharmacy
Asian Journal of Pharmaceutical and Clinical Research | Year: 2013

Starting from ancient period and traditional systems of medicine many medicinal plants are play a vital role in the treatment of several diseases. Medicinal plants possess valuable bioactive compounds that protects human from various complications. Therefore, there is a necessity to explore their uses and to conduct pharmacological studies to find out their therapeutic properties. Hence, the present study aims to open new avenues for the improvement of medicinal uses of fruit of Luffa cylindrica for the selected area for diabetes.


Bhaskar V.H.,P.A. College | Balakrishnan N.,Technocrats Institute of Technology Pharmacy
Pharmaceutical Biology | Year: 2010

Pergularia daemia (Forsk.) Chiov. (Asclepiadaceae) is used traditionally as an anthelmintic, laxative, antipyretic, and expectorant, and also used to treat malarial intermittent fever. But the scientific parameters are not yet available to identify the true plant material. In the present investigation, various pharmacognostic standards for P. daemia have been established. Microscopically, thick root and thick taproot of P. daemia showed the presence of periderm, secondary phloem and secondary xylem. Abundant starch grains and calcium oxalate crystals are present in the cortical parenchyma masses included within the xylem. Powdered roots of the plant showed vessel elements, tracheids, fibers and xylem parenchyma. Total ash of the root of P. daemia was not more than 5% and water-soluble extractive value was two times higher than alcohol soluble extractive value. Phytochemically, the ethanol and aqueous extracts of the root of P. daemia showed maximum phytochemicals such as alkaloids, glycosides, steroids, flavonoids, saponin, tannin and phenolic compounds, terpenoids, carbohydrates, gums and mucilage. The results of this study should provide a standard for identification and preparation of monograph of this drug.


Raj N.,Technocrats Institute of Technology Pharmacy | Nadeem S.,Technocrats Institute of Technology Pharmacy | Jain S.,Technocrats Institute of Technology Pharmacy | Raj C.,Technocrats Institute of Technology Pharmacy | Nandi K.C.P.,Technocrats Institute of Technology Pharmacy
Digest Journal of Nanomaterials and Biostructures | Year: 2011

Rhizomes of Alpinia calcarata Roscoe (Zingiberaceae) posses several bio-activities and are used in traditional medicine of India (kulanjan) and Sri Lanka. However, the effect of Alpinia calcarata on diabetic activity has not been investigated so far. The aim of this study therefore, was to examine the ameliorative effects of ethanolic extract Alpinia calcarata rhizomes (ACRE) in alloxan-induced diabetic rats models. The ethanolic extracts of Alpinia calcarata rhizomes (ACRE) significantly reduced the body weight gain, blood glucose level, plasma total cholesterol (TC) and triglyceride (TG) levels when given orally at a dose of 100, 200 and 300 mg/kg/day to the alloxan-induced diabetic rats for 21 days. In this study, the effects of Alpinia calcarata on the diabetes of alloxan-induced diabetic rats and possible transcriptional impact are investigated.


Bhaskar V.H.,P.A. College | Balakrishnan N.,Technocrats Institute of Technology Pharmacy
Pharmaceutical Biology | Year: 2010

Context: Pergularia daemia (Forsk) Chiov. (Asclepiadaceae) is a slender, hispid, fetid-smelling perennial climber and has been used for the treatment of inflammation, diabetes, malaria, asthma, and liver disorders. Ethnopharmacological surveys conducted among herbal practitioners of Western Ghats, Tamil Nadu, India, revealed that large numbers of laticiferous plant species are used as a source of herbal therapies, in which Pergularia daemia was commonly used to treat liver disease and jaundice. Objective: The hepatoprotective effect of aqueous and ethanol extracts of Pergularia daemia roots by paracetamol and carbon tetrachloride (CCl4)-induced liver damage in rats was studied. Materials and methods: The aqueous (PdAE) and ethanol (PdEE) extracts of Pergularia daemia were studied for their hepatoprotective effects on paracetamol and CCl4-induced liver damage on Wistar albino rats. The degree of protection was measured by physical changes (liver weight), biochemical (serum gultamic pyruvic transaminase, serum gultamic oxaloacetic transaminase, alkaline phosphatase, direct bilirubin, total bilirubin, cholesterol and decrease in protein), antioxidant enzymes (lipid peroxidation and glutathione levels), and histological changes. Results: Pretreatment with PdAE and PdEE significantly prevented the physical, biochemical, antioxidant enzyme levels and histological changes induced by paracetamol and CCl4 in the liver. The effects of PdAE and PdEE were comparable to that of the standard drug silymarin. The ethanol extract was found to exhibit greater hepatoprotective activity than the aqueous extract. Discussion and conclusion: These results indicate that Pergularia daemia could be useful in preventing chemically induced acute liver injury. From this study it can be concluded that the aqueous and ethanol extracts of P. daemia possess significant hepatoprotective activity. © 2010 Informa Healthcare USA, Inc.


Balakrishnan N.,Technocrats Institute of Technology Pharmacy | Singh B.,Technocrats Institute of Technology Pharmacy
Asian Journal of Chemistry | Year: 2013

The purpose of this study was to investigate the antidiabetic potential of the aqueous extracts of roots of Ventilago calyculata Tul. (VCAE) and ethanol extracts of roots of Ventilago calyculata Tul. (VCEE) in the alloxan included diabetic rats. Both extracts of Ventilago calyculata produced a significant antidiabetic activity at dose levels 200 and 400 mg/kg, body weight. Concurrent histological studies of the pancreas of these animals showed comparable regeneration by VCAE and VCEE, which were earlier, necrosed by alloxan.


PubMed | Technocrats Institute of Technology Pharmacy
Type: Journal Article | Journal: Avicenna journal of phytomedicine | Year: 2015

Tabernaemontana divaricata (TD) from Apocynaceae family offers the traditional folklore medicinal benefits such as an anti-epileptic, anti-mania, brain tonic, and anti-oxidant. The aim of the present study was to evaluate the effect of ethanolic extract of TD leaves on burying behavior in mice.Mice were treated with oral administration (p.o.) of ethanolic extract of TD (100, 200, and 300 mg/kg). Fluoxetine (FLX, a selective serotonin reuptake inhibitor) was used as a reference drug. Obsessive-compulsive behavior was evaluated using marble-burying apparatus.TD at doses of 100, 200, and 300 mg/kg dose-dependently inhibited the obsessive and compulsive behavior. The similar results were obtained from 5, 10, and 20 mg/kg of FLX. TD and FLX did not affect motor activity.The results indicated that TD and FLX produced similar inhibitory effects on marble-burying behavior.


PubMed | Technocrats Institute of Technology Pharmacy
Type: Journal Article | Journal: Pakistan journal of biological sciences : PJBS | Year: 2014

Oxidative stress is one of the major causative factors of many chronic and degenerative diseases. Plants have been used in traditional medicine in different parts of world for thousands of years and continue to provide new remedies for human kind. The present study was to investigate the preliminary phytochemical analysis of various extracts of roots and leaves of Trewia nudiflora (Euphorbiaceae) and antioxidant activity by 1,1,diphenyl-2-picryl hydrazyl (DPPH) radical scavenging method. The preliminary phytochemical screening showed the presence of several phytochemicals including alkaloids, glycosides, flavonoids, steroids, phenolic compounds and tannins. The ethanol and aqueous extracts of roots and leaves of Trewia nudiflora showed significant antioxidant activity compared to standard drug ascorbic acid.

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