The Technical University of Denmark , often simply referred to as DTU, is a university in Kongens Lyngby, just north of Copenhagen, Denmark. It was founded in 1829 at the initiative of Hans Christian Ørsted as Denmark's first polytechnic, and is today ranked among Europe's leading engineering institutions, and the best engineering university in the Nordic countries. Wikipedia.
Marvig R.L.,Technical University of Denmark
Nature Genetics | Year: 2014
Little is known about how within-host evolution compares between genotypically different strains of the same pathogenic species. We sequenced the whole genomes of 474 longitudinally collected clinical isolates of Pseudomonas aeruginosa sampled from 34 children and young individuals with cystic fibrosis. Our analysis of 36 P. aeruginosa lineages identified convergent molecular evolution in 52 genes. This list of genes suggests a role in host adaptation for remodeling of regulatory networks and central metabolism, acquisition of antibiotic resistance and loss of extracellular virulence factors. Furthermore, we find an ordered succession of mutations in key regulatory networks. Accordingly, mutations in downstream transcriptional regulators were contingent upon mutations in upstream regulators, suggesting that remodeling of regulatory networks might be important in adaptation. The characterization of genes involved in host adaptation may help in predicting bacterial evolution in patients with cystic fibrosis and in the design of future intervention strategies. © 2014 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. Source
Dana-Farber Cancer Institute, Childrens Medical Center Corporation, Brigham, Women's Hospital and Technical University of Denmark | Date: 2015-04-09
Provided is a method of predicting the prognosis of a patient with ovarian cancer by determining the total number of somatic exome mutations per genome (Nmut) and status of the BRCA1 and/or BRCA2 in the subject.
Technical University of Denmark | Date: 2014-04-04
The present invention relates to a micron-scale calorimeter and a calorimetry method utilizing the micron-scale calorimeter. In accordance with the invention, there is provided a micron-scale calorimeter comprising a micro-channel string, being restrained at at least two longitudinally distanced positions so as to form a free released double clamped string in-between said two longitudinally distanced positions said micro-channel string comprising a microfluidic channel having a closed cross section and extending in the longitudinal direction of the hollow string, acoustical means adapted to oscillate the string at different frequencies by emitting sound waves towards the string, optical means adapted to detect oscillating frequencies of the string, and controlling means controlling the strength and frequency of the sound wave emitted by the acoustical means and receiving a signal from the optical means representing the detected oscillating frequencies.
Technical University of Denmark | Date: 2014-01-31
Technical University of Denmark | Date: 2014-03-18
In a method for performing a refractive index based measurement of a property of a fluid such as chemical composition or temperature, a chirp in the local spatial frequency of interference fringes of an interference pattern is reduced by mathematical manipulation of the recorded light intensity in the interference pattern or by the physical positioning and arrangement of a detector used for capturing the interference pattern.