The Technical University of Denmark , often simply referred to as DTU, is a university in Kongens Lyngby, just north of Copenhagen, Denmark. It was founded in 1829 at the initiative of Hans Christian Ørsted as Denmark's first polytechnic, and is today ranked among Europe's leading engineering institutions, and the best engineering university in the Nordic countries. Wikipedia.
Marvig R.L.,Technical University of Denmark
Nature Genetics | Year: 2014
Little is known about how within-host evolution compares between genotypically different strains of the same pathogenic species. We sequenced the whole genomes of 474 longitudinally collected clinical isolates of Pseudomonas aeruginosa sampled from 34 children and young individuals with cystic fibrosis. Our analysis of 36 P. aeruginosa lineages identified convergent molecular evolution in 52 genes. This list of genes suggests a role in host adaptation for remodeling of regulatory networks and central metabolism, acquisition of antibiotic resistance and loss of extracellular virulence factors. Furthermore, we find an ordered succession of mutations in key regulatory networks. Accordingly, mutations in downstream transcriptional regulators were contingent upon mutations in upstream regulators, suggesting that remodeling of regulatory networks might be important in adaptation. The characterization of genes involved in host adaptation may help in predicting bacterial evolution in patients with cystic fibrosis and in the design of future intervention strategies. © 2014 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.
Sorensen J.N.,Technical University of Denmark
Annual Review of Fluid Mechanics | Year: 2011
This article reviews the most important aerodynamic research topics in the field of wind energy. Wind turbine aerodynamics concerns the modeling and prediction of aerodynamic forces, such as performance predictions of wind farms, and the design of specific parts of wind turbines, such as rotor-blade geometry. The basics of the blade-element momentum theory are presented along with guidelines for the construction of airfoil data. Various theories for aerodynamically optimum rotors are discussed, and recent results on classical models are presented. State-of-the-art advanced numerical simulation tools for wind turbine rotors and wakes are reviewed, including rotor predictions as well as models for simulating wind turbine wakes and flows in wind farms. © 2011 by Annual Reviews. All rights reserved.
Markussen T.,Technical University of Denmark
Nano Letters | Year: 2012
Ge-Si core-shell nanowires with surface disorder are shown to be very promising candidates for thermoelectric applications. In atomistic calculations we find that surface roughness decreases the phonon thermal conductance significantly. On the contrary, the hole states are confined to the Ge core and are thereby shielded from the surface disorder, resulting in large electronic conductance values even in the presence of surface disorder. This decoupling of the electronic and phonon transport is very favorable for thermoelectric purposes, giving rise to promising room temperature figure of merits ZT > 2. It is also found that the Ge-Si core-shell wires perform better than pure Si nanowires. © 2012 American Chemical Society.
Schmidt S.,Technical University of Denmark
Journal of Applied Crystallography | Year: 2014
A new approach for indexing multigrain diffraction data is presented. It is based on the use of a monochromatic beam simultaneously illuminating all grains. By operating in sub-volumes of Rodrigues space, a powerful vertex-finding algorithm can be applied, with a running time that is compatible with online analysis. The resulting program, GrainSpotter, is sufficiently fast to enable online analysis during synchrotron sessions. The program applies outlier rejection schemes, leading to more robust and accurate data. By simulations it is shown that several thousand grains can be retrieved. A new method to derive partial symmetries, called pseudo-twins, is introduced. Uniquely, GrainSpotter includes an analysis of pseudo-twins, which is shown to be critical to avoid erroneous grains resulting from the indexing. © 2014 International Union of Crystallography.
Kiorboe T.,Technical University of Denmark
Biological Reviews | Year: 2011
Zooplankton is a morphologically and taxonomically diverse group and includes organisms that vary in size by many orders of magnitude, but they are all faced with the common problem of collecting food from a very dilute suspension. In order to maintain a viable population in the face of mortality, zooplankton in the ocean have to clear daily a volume of ambient water for prey particles that is equivalent to about 106 times their own body volume. While most size-specific vital rates and mortality rates decline with size, the clearance requirement is largely size-independent because food availability also declines with size. There is a limited number of solutions to the problem of concentrating dilute prey from a sticky medium: passive and active ambush feeding; feeding-current feeding, where the prey is either intercepted directly, retained on a filter, or individually perceived and extracted from the feeding current; cruise feeding; and colonization of large particles and marine snow aggregates. The basic mechanics of these food-collection mechanisms are described, and it is shown that their efficiencies are inherently different and that each of these mechanisms becomes less efficient with increasing size. Mechanisms that compensate for this decline in efficiency are described, including inflation of feeding structures and development of vision. Each feeding mode has implications beyond feeding in terms of risk of encountering predators and chance of meeting mates, and they partly target different types of prey. The main dichotomy is between (inefficient) ambush feeding on motile prey and the more efficient active feeding modes; a secondary dichotomy is between (efficient) hovering and (less efficient) cruising feeding modes. The efficiencies of the various feeding modes are traded off against feeding-mode-dependent metabolic expenses, predation risks, and mating chances. The optimality of feeding strategies, evaluated as the ratio of gain over risk, varies with the environment, and may explain both size-dependent and spatio-temporal differences in distributions of various feeding types as well as other aspects of the biology of zooplankton (mating behaviour, predator defence strategies). © 2010 The Author. Biological Reviews © 2010 Cambridge Philosophical Society.