The Technical University of Denmark , often simply referred to as DTU, is a university in Kongens Lyngby, just north of Copenhagen, Denmark. It was founded in 1829 at the initiative of Hans Christian Ørsted as Denmark's first polytechnic, and is today ranked among Europe's leading engineering institutions, and the best engineering university in the Nordic countries. Wikipedia.
Technical University of Denmark | Date: 2017-01-04
The present invention relates to a new method of power converter regulation, in particular regulation of very high frequency (VHF) power converters operating at frequencies in the MHz range, wherein accurate output regulation utilises inherent delays in the regulation loop, whereby, contrary to hysteresis on/off control, the new method does not require immediate responses to comparisons of a sense voltage to two reference voltages; rather, according to the new method, only one reference voltage is used, and delays in the feedback loop are allowed to cause some variation of an output of the power converter.
Technical University of Denmark | Date: 2017-04-19
Technical University of Denmark | Date: 2017-02-01
The present disclosure relates to a filament stretching rheometer for measuring rheological and/or mechanical properties of a sample, comprising: a pair of opposed surfaces for holding the sample therebetween; an actuator configured to provide a controlled axial displacement of at least one of said opposed surfaces; and a sample scanning unit for measuring a diameter of said sample, the sample scanning unit configured for measuring said sample diameter at an axial position controlled independently of the displacement of the opposed surfaces, the sample scanning unit configured for being positioned at a starting point before said controlled axial displacement, wherein the starting point is selected from a position where a minimum diameter of the said sample is determined by said sample scanning unit.
Technical University of Denmark | Date: 2017-03-15
The invention provides a method for the preparation of regioisomerically pure intermediates which are useful for the preparation of carboxy-fluorescein-type compounds. Such compounds have broad applications within bio-conjugation and/or fluorescent imaging.
Technical University of Denmark | Date: 2017-01-04
The present invention relates to a resonant DC-DC power converter comprising an input side circuit comprising a positive and a negative input terminal for receipt of an input voltage or current and an output side circuit comprising positive and negative output terminals for supply of a converter output voltage and connection to a converter load. The resonant DC-DC power converter further comprises a rectification circuit connected between an output of a resonant network and the output side circuit. The resonant network is configured for alternatingly being charged from the input voltage or current and discharged through the rectification circuit by a first controllable switch arrangement in accordance with a first switch control signal. A second controllable switch arrangement of the resonant DC-DC power converter is configured to select a first impedance characteristic of the resonant network in a first switch state and select a second impedance characteristic of the resonant network in a second switch state. An output voltage or current control circuit is configured to adjust the converter output voltage and/or current by activating and interrupting the first switch control signal in accordance with the switch state of the second controllable switch arrangement.
Technical University of Denmark | Date: 2017-02-08
The present invention relates to a rotor for a pyrolysis centrifuge reactor, said rotor comprising a rotor body having a longitudinal centre axis, and at least one pivotally mounted blade being adapted to pivot around a pivot axis under rotation of the rotor body around the longitudinal centre axis. Moreover, the present invention relates to a pyrolysis centrifuge reactor applying such a rotor.
Technical University of Denmark | Date: 2017-02-15
The invention relates to a VCSEL structure based on a novel grating reflector. The grating reflector (1) comprises a grating layer (20) with a contiguous core grating region having a grating structure, wherein an index of refraction of high-index sections (21) of the grating structure is at least 2.5, and wherein an index of refraction of low-index sections (22) of the grating structure is less than 2. The core grating region defines a projection in a direction normal to the grating layer. The grating reflector further comprises a cap layer (30) abutting the grating layer (20), and an index of refraction of the cap layer within the projection of the core grating region onto the cap layer is at least 2.5, and within the projection of the core grating region, the cap layer is abutted by a first solid dielectric low-index layer, an index of refraction of the first low-index layer or air being less than 2; and within the projection of the core grating region, the grating layer is also abutted by a second low-index layer and/or by air, an index of refraction of the second low-index layer or air being less than 2. The VCSEL structure furthermore comprises a first reflector and an active region for providing a cavity and amplification. The cap layer (30) may comprise an active layer (32) between cladding layers (31,33) and electrical contacts (35,36) to provide a current through the active layer. Current confinement may be realized by low-index oxide regions (60).
Technical University of Denmark | Date: 2017-03-01
The present invention relates e.g. to methods of producing statins in transgenic, non-filamentous microorganisms such as Saccharomyces cerevisiae. In addition, the present invention relates to the transgenic, non-filamentous microorganisms as such as well as various uses of transmembrane statin efflux pump(s) originating from various filamentous fungi. Moreover, the present invention relates to the transferring the compactin, lovastatin or monacolin K gene cluster originating from non-filamentous fungi into easily fermentable microorganisms, followed by expression or overexpression of the efflux pump encoding genes in said microorganisms in order to increase the microorganisms resistance to statins which in turn allows for production of elevated concentrations of natural statins compared to statin-producing methods known in the art.
Marvig R.L.,Technical University of Denmark
Nature genetics | Year: 2015
Little is known about how within-host evolution compares between genotypically different strains of the same pathogenic species. We sequenced the whole genomes of 474 longitudinally collected clinical isolates of Pseudomonas aeruginosa sampled from 34 children and young individuals with cystic fibrosis. Our analysis of 36 P. aeruginosa lineages identified convergent molecular evolution in 52 genes. This list of genes suggests a role in host adaptation for remodeling of regulatory networks and central metabolism, acquisition of antibiotic resistance and loss of extracellular virulence factors. Furthermore, we find an ordered succession of mutations in key regulatory networks. Accordingly, mutations in downstream transcriptional regulators were contingent upon mutations in upstream regulators, suggesting that remodeling of regulatory networks might be important in adaptation. The characterization of genes involved in host adaptation may help in predicting bacterial evolution in patients with cystic fibrosis and in the design of future intervention strategies.
Kepp K.P.,Technical University of Denmark
Chemical Reviews | Year: 2012
A study was conducted to investigate the bioinorganic chemistry of Alzheimer's disease (AD). The two main histopathological criteria for AD were observations of extracellular deposits of fibrillar peptides, called senile plaques and of widespread intraneuronal fibrillar tangles. The senile plaques were formed from ̃40-residue fragments known as β-amyloids (Aβ), of the transmembrane amyloid precursor protein (APP) found in the membranes of cells and organelles such as mitochondria. The neurofibrillar tangles consisted of twisted strands of hyperphosphorylated tau protein, which was important for the structural integrity of microtubules, structural tubulin polymers of the cytoskeleton of the neurons, and were commonly observed upon neurodegeneration. The amyloid cascade hypothesis stated that impaired balance between Aβ production and clearance was the main cause of AD and that amyloids were the main neurotoxic substances in the disease.