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Delft, Netherlands

Delft University of Technology ft]), also known as TU Delft, is the largest and oldest Dutch public technical university, located in Delft, Netherlands. With eight faculties and numerous research institutes it hosts over 19,000 students , more than 3,300 scientists and more than 2,200 people in the support and management staff.The university was established on January 8, 1842 by King William II of the Netherlands as a Royal Academy, with the main purpose of training civil servants for the Dutch East Indies. The school rapidly expanded its research and education curriculum, becoming first a Polytechnic School in 1864, Institute of Technology in 1905, gaining full university rights, and finally changing its name to Delft University of Technology in 1986.Dutch Nobel laureates Jacobus Henricus van 't Hoff, Heike Kamerlingh Onnes, and Simon van der Meer have been associated with TU Delft. TU Delft is a member of several university federations including the IDEA League, CESAER, UNITECH, and 3TU. Wikipedia.


Peters J.A.,Technical University of Delft
Coordination Chemistry Reviews | Year: 2014

The general principles of interaction between bor(on)ic acids and sugars in aqueous media are discussed with a focus on the structural aspects that play a role with respect to the regioselectivity of the interactions and the stability of the resulting adducts. Preorganization and pKas appear to play important roles. Glucose and sialic acid will be demonstrated to be the promising targets for artificial B-based sensors. These sugars are important markers for diabetes and cancer, respectively. © 2014 Elsevier B.V.


Straathof A.J.J.,Technical University of Delft
Chemical Reviews | Year: 2014

Transformation of biomass into commodity chemicals using enzymes or cells will be successful if the production process is more attractive than for alternative options to produce these chemicals. Sufficient second generation biomass should be available for a reasonable price, the price will not only be dictated by the biomass production but also by competitive uses of this biomass such as combustion for energy generation. All biomass components should be convertible into product, or otherwise into valuable coproduct. Too high bioreactor investments, due to high O2 requirements or too low productivities, should be avoided. Biochemical processes compete with chemical processes that aim at similar routes from biomass to product. The biochemical process should be more selective or should avoid production and isolation of intermediate chemicals. Scientific discoveries and method development have been very important to increase the rate of development of biochemical routes.


Schneider G.F.,Technical University of Delft
Nature communications | Year: 2013

Graphene nanopores are potential successors to biological and silicon-based nanopores. For sensing applications, it is however crucial to understand and block the strong nonspecific hydrophobic interactions between DNA and graphene. Here we demonstrate a novel scheme to prevent DNA-graphene interactions, based on a tailored self-assembled monolayer. For bare graphene, we encounter a paradox: whereas contaminated graphene nanopores facilitated DNA translocation well, clean crystalline graphene pores very quickly exhibit clogging of the pore. We attribute this to strong interactions between DNA nucleotides and graphene, yielding sticking and irreversible pore closure. We develop a general strategy to noncovalently tailor the hydrophobic surface of graphene by designing a dedicated self-assembled monolayer of pyrene ethylene glycol, which renders the surface hydrophilic. We demonstrate that this prevents DNA to adsorb on graphene and show that single-stranded DNA can now be detected in graphene nanopores with excellent nanopore durability and reproducibility.


Sheldon R.A.,Technical University of Delft
Chemical Society Reviews | Year: 2012

In this tutorial review, the fundamental concepts underlying the principles of green and sustainable chemistry - atom and step economy and the E factor - are presented, within the general context of efficiency in organic synthesis. The importance of waste minimisation through the widespread application of catalysis in all its forms - homogeneous, heterogeneous, organocatalysis and biocatalysis - is discussed. These general principles are illustrated with simple practical examples, such as alcohol oxidation and carbonylation and the asymmetric reduction of ketones. The latter reaction is exemplified by a three enzyme process for the production of a key intermediate in the synthesis of the cholesterol lowering agent, atorvastatin. The immobilisation of enzymes as cross-linked enzyme aggregates (CLEAs) as a means of optimizing operational performance is presented. The use of immobilised enzymes in catalytic cascade processes is illustrated with a trienzymatic process for the conversion of benzaldehyde to (S)-mandelic acid using a combi-CLEA containing three enzymes. Finally, the transition from fossil-based chemicals manufacture to a more sustainable biomass-based production is discussed. © 2012 The Royal Society of Chemistry.


Reiserer A.,Technical University of Delft | Rempe G.,Max Planck Institute of Quantum Optics
Reviews of Modern Physics | Year: 2015

Distributed quantum networks will allow users to perform tasks and to interact in ways which are not possible with present-day technology. Their implementation is a key challenge for quantum science and requires the development of stationary quantum nodes that can send and receive as well as store and process quantum information locally. The nodes are connected by quantum channels for flying information carriers, i.e., photons. These channels serve both to directly exchange quantum information between nodes and to distribute entanglement over the whole network. In order to scale such networks to many particles and long distances, an efficient interface between the nodes and the channels is required. This article describes the cavity-based approach to this goal, with an emphasis on experimental systems in which single atoms are trapped in and coupled to optical resonators. Besides being conceptually appealing, this approach is promising for quantum networks on larger scales, as it gives access to long qubit coherence times and high light-matter coupling efficiencies. Thus, it allows one to generate entangled photons on the push of a button, to reversibly map the quantum state of a photon onto an atom, to transfer and teleport quantum states between remote atoms, to entangle distant atoms, to detect optical photons nondestructively, to perform entangling quantum gates between an atom and one or several photons, and even provides a route toward efficient heralded quantum memories for future repeaters. The presented general protocols and the identification of key parameters are applicable to other experimental systems. © 2015 American Physical Society.

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